• Phone: 0522 2718505
  • iorarcstt@cimap.res.in

Plant Details

Plectranthus amboinicus

BOTANICAL DETAILS OF PLANT

Synonyms

Coleus amboinicus Lour. Coleus amboinicus var. violaceus Gürke Coleus aromaticus Benth. Coleus carnosus Hassk. Coleus crassifolius Benth. Coleus subfrutectosus Summerh. Coleus suborbicularis Zoll. & Moritzi Coleus suganda Blanco Coleus vaalae (Forssk.) Deflers Majana amboinica (Lour.) Kuntze Majana carnosa (Hassk.) Kuntze Majana suganda (Blanco) Kuntze Ocimum vaalae Forssk.

Kew Herbarium Links

Herbarium 1

Herbarium 2

Herbarium 3

Herbarium 4

Classification

Kingdom

Plantae

Subkingdom

Viridiplantae

Superdivision

Embryophyta

Division

Tracheophyta

Class

Magnoliopsida

Subclass

Order

Lamiales

Family

Lamiaceae

Genus

Plectranthus

Species

amboinicus

Plant Description

Coleus amboinicus is a rapid growing, branched, evergreen, ascending, spreading shrublet, 300–700 mm tall. The roots are fibrous. All parts are highly and pleasantly aromatic. The stems are ascending spreading (decumbent) and up to 1.5 m long, succulent, almost rounded to somewhat 4-angled, green when young and about 4 mm in diameter, the mature stems becoming brownish and about 7 mm in diameter. The stem surface is covered in dense, whitish, translucent, long and short, multicellular hairs. The internodes are 5–55 mm apart, depending on the growing conditions. Leaves are brittle, broadly egg-shaped to triangularly egg-shaped (ovate) with a short petiole 8–20 mm long; the blade is 35–50 mm long and 25–47 mm in diameter. When grown under exposed, sunny, dry conditions, the leaves are shorter and folded in (conduplicate), however, in shady, moist conditions the leaves tend to be flattened and only slightly concave. The margin with about 12 pairs of shallow pointed teeth. The base of the leaf is truncate and the tip (apex) acute to almost rounded. The surface is covered in tiny, translucent to brownish gland dots and is very hairy, especially on the conspicuous network of veins on the lower surface. The inflorescence is a terminal raceme, 100 to 500 mm long; the flowers are arranged in whorls of 4–10, each flower 7–9 mm long, white to mauve and slightly deflexed, expanding to the throat. The calyx is 2–3 mm long, elongating to 5–6 mm when mature. The seed is a light to dark brown, slightly flattened nutlet, 1 mm across. Flowering time is late summer to autumn, the seeds released in winter and spring. In cultivation, and especially the tropics, it can flower at other times of the year.

Habit/Life Form

-

DISTRIBUTION OF SPECIES IN INDIA

-

Plant Parts Used

-

System of Medicine

-

Intended Use

Asthma, flu, eczema, cardiovascular disorders, bronchitis, epilepsy, Cough, flatulence, rheumatism, furuncle sprain, painful swelling, malaria, stomachaches, diarrhoea, vaginal infection, laxative and hiccup.

Traditional Application

In Archipelago of Comoros, the roots are used against malaria 2, the leaves for their antitussive activity 3 and the decoction of the whole plant can have a triple use: sedative of the abdominal gripes, medication of the dysuria and laxative (M. Saïd Hassani, I. Zainati, S. Zrira, S. Mahdi & M. Oukessou (2012) Chemical Composition and Antimicrobial Activity of Plectranthus amboinicus (Lour) Spring. Essential Oil from Archipelago of Comoros, Journal of Essential Oil-Bearing Plants, 15:4, 637-644, DOI: 10.1080/0972060X.2012.10644098) (Matthew Saive, Michel Frederich & Marie-Laure Fauconnier.

Plants used in traditional medicine in the Comoros archipelago. A review ,Portada Volume 24 (2020) Numéro 2 / 10.25518/1780-4507.18553).

Uses in IORA Countries

# Country Name Uses
1 Srilanka In Srilanka, herb is used for whooping cough,bronchitis,pneumonia,asthma,chicken pox,cough,dysentry,liver diseases, worm infestation,renal calculi,eye diseases.
2 Malaysia In Malaysia to treat burns and as a poultice for centipedes and scorpion bites
3 India In India, the herb is highly useful and popular in treating respiratory disorders.It is consumed to alleviate congestion,sinusitis ,asthma,cold and sore throat

Phytochemical Details

# Phytochemical Constituents PUBCHEM CID References
1 δ-3-Carene 26049 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040369 M. Saïd Hassani, I. Zainati, S. Zrira, S. Mahdi & M. Oukessou (2012) Chemical Composition and Antimicrobial Activity of Plectranthus amboinicus (Lour) Spring. Essential Oil from Archipelago of Comoros, Journal of Essential Oil Bearing Plants, 15:4, 637-644, DOI: 10.1080/0972060X.2012.10644098
2 p-Cymene 7463 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040370 M. Saïd Hassani, I. Zainati, S. Zrira, S. Mahdi & M. Oukessou (2012) Chemical Composition and Antimicrobial Activity of Plectranthus amboinicus (Lour) Spring. Essential Oil from Archipelago of Comoros, Journal of Essential Oil Bearing Plants, 15:4, 637-644, DOI: 10.1080/0972060X.2012.10644098
3 Limonene 22311 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040371
4 ß-Myrcene 31253 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040372
5 Ocimene 18756 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040373
6 α-Phellandrene 7460 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040374
7 β-Phellandrene 11142 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040375
8 α-Pinene 6654 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040376
9 β-Pinene 14896 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040377
10 Sabinene 18818 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040378
11 α-Terpinene 7462 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040379
12 Ƴ-Terpinene 7461 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040380 M. Saïd Hassani, I. Zainati, S. Zrira, S. Mahdi & M. Oukessou (2012) Chemical Composition and Antimicrobial Activity of Plectranthus amboinicus (Lour) Spring. Essential Oil from Archipelago of Comoros, Journal of Essential Oil Bearing Plants, 15:4, 637-644, DOI: 10.1080/0972060X.2012.1064409
13 α-Terpinolene 17100 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040380 M. Saïd Hassani, I. Zainati, S. Zrira, S. Mahdi & M. Oukessou (2012) Chemical Composition and Antimicrobial Activity of Plectranthus amboinicus (Lour) Spring. Essential Oil from Archipelago of Comoros, Journal of Essential Oil Bearing Plants, 15:4, 637-644, DOI: 10.1080/0972060X.2012.1064409
14 α-Thujene 17868 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040382 M. Saïd Hassani, I. Zainati, S. Zrira, S. Mahdi & M. Oukessou (2012) Chemical Composition and Antimicrobial Activity of Plectranthus amboinicus (Lour) Spring. Essential Oil from Archipelago of Comoros, Journal of Essential Oil Bearing Plants, 15:4, 637-644, DOI: 10.1080/0972060X.2012.10644098 M. Saïd Hassani, I. Zainati, S. Zrira, S. Mahdi & M. Oukessou (2012) Chemical Composition and Antimicrobial Activity of Plectranthus amboinicus (Lour) Spring. Essential Oil from Archipelago of Comoros, Journal of Essential Oil Bearing Plants, 15:4, 637-644, DOI: 10.1080/0972060X.2012.10644098
15 Camphor((22.2 %)) 2537 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040383
16 Carvacrol ((23.0 %)) 10364 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040384
17 Carvone 7439 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040384
18 1,8-Cineole 2758 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040384
19 Eugenol 3314 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040384
20 Geraniol 637566 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040384
21 Linalool 6549 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040389
22 Geranyl acetate 1549026 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040389
23 Methyl eugenol 7127 Arumugam G, Swamy MK, Sinniah UR. Plectranthus amboinicus (Lour.) Spreng: Botanical, Phytochemical, Pharmacological and Nutritional Significance. Molecules. 2016; 21(4):369. https://doi.org/10.3390/molecules21040389

Pharmacological Details

# PHARMACOLOGICAL ACTIONS/THERAPEUTIC USES REFERENCES
1 Antimalarial activity

Ali Mohamed Kaou, Valérie Mahiou-Leddet, Sébastien Hutter, Sidi Aïnouddine, Said Hassani, Ibrahim Yahaya, Nadine Azas, Evelyne Ollivier,Antimalarial activity of crude extracts from nine African medicinal plants,Journal of Ethnopharmacology,Volume 116, Issue 1,2008, Pages 74-83, ISSN 0378-8741,https://doi.org/10.1016/j.jep.2007.11.001.                      

Periyanayagam K, Nirmala Devi K, Suseela L, Uma A, Ismail M. In vivo antimalarial activity of leaves of Plectranthus amboinicus (lour) spreng on Plasmodium berghei yoelii. J Commun Dis. 2008 Jun;40(2):121-5. PMID: 19301696. 

 doi: 10.4103/0974-8490.138248. PMID: 25276063; PMCID: PMC4166814.

Senthilkumar A, Venkatesalu V. Chemical composition and larvicidal activity of the essential oil of Plectranthus amboinicus (Lour.) Spreng against Anopheles stephensi: a malarial vector mosquito. Parasitol Res. 2010 Oct;107(5):1275-8. doi: 10.1007/s00436-010-1996-6. Epub 2010 Jul 29. PMID: 20668876.

2 Antimicrobial activity
Vasconcelos SECB, Melo HM, Cavalcante TTA, Júnior FEAC, de Carvalho MG, Menezes FGR, de Sousa OV, Costa RA. Plectranthus amboinicus essential oil and carvacrol bioactive against planktonic and biofilm of oxacillin- and vancomycin-resistant Staphylococcus aureus. BMC Complement Altern Med. 2017 Sep 16;17(1):462. doi: 10.1186/s12906-017-1968-9. PMID: 28915875; PMCID: PMC5602841. 
                  
Shubha JR, Bhatt P. Plectranthus amboinicus leaves stimulate growth of probiotic L. plantarum: evidence for ethnobotanical use in diarrhea. J Ethnopharmacol. 2015 May 26; 166:220-7. doi: 10.1016/j.jep.2015.02.055. Epub 2015 Mar 19. PMID: 25796406.         

 Ajitha B, Ashok Kumar Reddy Y, Sreedhara Reddy P. Biosynthesis of silver nanoparticles using Plectranthus amboinicus leaf extract and its antimicrobial activity. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jul 15; 128:257-62. doi: 10.1016/j.saa.2014.02.105. Epub 2014 Mar 7. PMID: 24674916.

 Gonçalves TB, Braga MA, de Oliveira FF, Santiago GM, Carvalho CB, Brito e Cabral P, de Melo Santiago T, Sousa JS, Barros EB, do Nascimento RF, Nagao-Dias AT. Effect of subinihibitory and inhibitory concentrations of Plectranthus amboinicus (Lour.) Spreng essential oil on Klebsiella pneumoniae. Phytomedicine. 2012 Aug 15;19(11):962-8. doi: 10.1016/j.phymed.2012.05.013. Epub 2012 Jul 8. PMID: 22776104. 
 
 Swamy MK, Arumugam G, Kaur R, Ghasemzadeh A, Yusoff MM, Sinniah UR. GC-MS Based Metabolite Profiling, Antioxidant and Antimicrobial Properties of Different Solvent Extracts of Malaysian Plectranthus amboinicus Leaves. Evid Based Complement Alternat Med. 2017; 2017:1517683. doi: 10.1155/2017/1517683. Epub 2017 Mar 23. PMID: 28424737; PMCID: PMC5382359.  

 de Oliveira FF, Torres AF, Gonçalves TB, Santiago GM, de Carvalho CB, Aguiar MB, Camara LM, Rabenhorst SH, Martins AM, Valença Junior JT, Nagao-Dias AT. Efficacy of Plectranthus amboinicus (Lour.) Spreng in a Murine Model of Methicillin-Resistant Staphylococcus aureus Skin Abscesses. Evid Based Complement Alternat Med. 2013; 2013:291592. doi: 10.1155/2013/291592. Epub 2013 Feb 20. PMID: 23533472; PMCID: PMC3590755.     
3 Anti-leishmanicidal activit
de Lima SC, Teixeira MJ, Lopes JE Jr, de Morais SM, Torres AF, Braga MA, Rodrigues RO, Santiago GM, Martins AC, Nagao-Dias AT. In vitro and in vivo leishmanicidal activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis. Biomed Res Int. 2014;2014:848293. doi: 10.1155/2014/848293. Epub 2014 Apr 16. PMID: 24829921; PMCID: PMC4009211.
4 Anti-inflammatory activity
Chen YS, Yu HM, Shie JJ, Cheng TJ, Wu CY, Fang JM, Wong CH. Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity. Bioorg Med Chem. 2014 Mar 1;22(5):1766-72. doi: 10.1016/j.bmc.2014.01.009. Epub 2014 Jan 12. PMID: 24491635.
               
Hsu YC, Cheng CP, Chang DM. Plectranthus amboinicus attenuates inflammatory bone erosion in mice with collagen-induced arthritis by downregulation of RANKL-induced NFATc1 expression. J Rheumatol. 2011 Sep;38(9):1844-57. doi: 10.3899/jrheum.101223. Epub 2011 Jul 1. PMID: 21724708.
                       
Gurgel AP, da Silva JG, Grangeiro AR, Oliveira DC, Lima CM, da Silva AC, Oliveira RA, Souza IA. In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae). J Ethnopharmacol. 2009 Sep 7;125(2):361-3. doi: 10.1016/j.jep.2009.07.006. Epub 2009 Jul 14. PMID: 19607901.                           

Ravikumar VR, Dhanamani M, Sudhamani T. In-vitro anti- inflammatory activity of aqueous extract of leaves of Plectranthus amboinicus (Lour.) Spreng. Anc Sci Life. 2009 Apr;28(4):7-9. PMID: 22557324; PMCID: PMC3336327.                  
5 Antidiabetic activity
Koti BC, Gore A, Thippeswamy AH, Swamy AH, Kulkarni R. Alcoholic leaf extract of Plectranthus amboinicus regulates carbohydrate metabolism in alloxan-induced diabetic rats. Indian J Pharmacol. 2011 May;43(3):286-90. doi: 10.4103/0253-7613.81520. PMID: 21713092; PMCID: PMC3113380.
6 Antineoplastic activity
Gurgel AP, da Silva JG, Grangeiro AR, Oliveira DC, Lima CM, da Silva AC, Oliveira RA, Souza IA. In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae). J Ethnopharmacol. 2009 Sep 7;125(2):361-3. doi: 10.1016/j.jep.2009.07.006. Epub 2009 Jul 14. PMID: 19607901.               
Manjamalai A, Grace VM. The chemotherapeutic effect of essential oil of Plectranthus amboinicus (Lour) on lung metastasis developed by B16F-10 cell line in C57BL/6 mice. Cancer Invest. 2013 Jan;31(1):74-82. doi: 10.3109/07357907.2012.749268. Epub 2012 Dec 18. PMID: 23249189.            

 Yulianto W, Andarwulan N, Giriwono PE, Pamungkas J. HPLC-based metabolomics to identify cytotoxic compounds from Plectranthus amboinicus (Lour.) Spreng against human breast cancer MCF-7Cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 15;1039:28-34. doi: 10.1016/j.jchromb.2016.10.024. Epub 2016 Oct 22. PMID: 27816313.
7 Diuretic activity
Patel R, Mahobia NK, Gendle R, Kaushik B, Singh SK. Diuretic activity of leaves of Plectranthus amboinicus (Lour) Spreng in male albino rats. Pharmacognosy Res. 2010 Mar;2(2):86-8. doi: 10.4103/0974-8490.62956. PMID: 21808546; PMCID: PMC3140112.
8 Analgesic activity
Chiu YJ, Huang TH, Chiu CS, Lu TC, Chen YW, Peng WH, Chen CY. Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo. Evid Based Complement Alternat Med. 2012;2012:508137. doi: 10.1155/2012/508137. Epub 2011 Sep 11. PMID: 21915187; PMCID: PMC3170901.
9 Rheumatoid arthritis
Chang JM, Cheng CM, Hung LM, Chung YS, Wu RY. Potential Use of Plectranthus amboinicus in the Treatment of Rheumatoid Arthritis. Evid Based Complement Alternat Med. 2010 Mar;7(1):115-20. doi: 10.1093/ecam/nem168. Epub 2007 Nov 23. PMID: 18955284; PMCID: PMC2816374.                                                                                                                                         
 Hsu YC, Cheng CP, Chang DM. Plectranthus amboinicus attenuates inflammatory bone erosion in mice with collagen-induced arthritis by downregulation of RANKL-induced NFATc1 expression. J Rheumatol. 2011 Sep;38(9):1844-57. doi: 10.3899/jrheum.101223. Epub 2011 Jul 1. PMID: 21724708.
10 Nephroprotective
Palani S, Raja S, Naresh R, Kumar BS. Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthus amboinicus on acetaminophen-induced nephrotoxic rats. Toxicol Mech Methods. 2010 May;20(4):213-21. doi: 10.3109/15376511003736787. PMID: 20367443.

Marketed Products

# AVALAIBLE PRODUCTS MANUFACTURERS AND SUPPLIERS URL
1 KILLI Karpooravalli KILLI farm made Open Url
2 Neotea Karpooravalli Coleus Amboinicus Powder Neotea Open Url

Market Overview

Global End Use Market

pharmaceutical Traditional/folklore

Available Global Market

-

Global Manufacturer Extract

-

Distribution in IORA Countries

Comoros Kenya Madagascar Mozambique Seychelles South Africa Tanzania Bangladesh India Indonesia Sri Lanka Thailand Yemen Australia Mauritius.

Trade Data

Source Supply

Tropical regions of the world, woodland, near coastals , and roadsides

Trade Name

-

Annual Consumption (in MT)

-

PATENTS

# PATENT TITLE PATENT/APPLICATION NO. PATENT OFFICE SOURCE
1 Multifunctional healthcare soap and manufacturing method thereof CN110205212 (A) -- Details
2 IMMUNOLOGICAL ENHANCER JPS6259218 (A) -- Details
3 MODIFIED NUTRACEUTICAL COMPOSITION WO2005094854 (A1) -- Details

Adulterant/Substitute

CULTIVARS AND VARIETIES