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Pueraria tuberosa (Willd.) DC.
BOTANICAL DETAILS OF PLANT
Synonyms
Hedysarum tuberosum Willd.
Kew Herbarium Links
Classification
Kingdom
Plantae
Subkingdom
Tracheobionta
Superdivision
Spermatophyta
Division
Magnoliophyta
Class
--
Subclass
Rosidae
Order
Fabales
Family
Fabaceae
Genus
Pueraria DC.
Species
Pueraria tubersora
Plant Description
Large woody climber, perennial, root tuberous, tubers large, up to 35 kg, often in strings. Branches sturdy, young branches grey pubescent, Stipules peltate. Leaves pinnately 3- foliate,10-22 cm long, rachis 1-6 cm long. Leaflets ovate to orbicular-ovate, acuminate, base rounded to wide acuminate, terminal leaflet broadly ovate, acuminate, the lateral leaflet ovate-oblong, very oblique, unequal, leaves green and glabrescent above, glabrous when mature, light green and densely grey pubescent below, ribs prominent, 6-9 pairs. Inflorescence axillary or terminal raceme, upright, 20-50 cm long, densly covered with short grey hairs, Pedicel 2-3 mm long, bracts lanceolate, very caducous: bracteoles small, flowers 2 per node sometimes 3, tip obtuse, long pubescent. Calyx grey to light brown pubescent, 6-8 mm long, as long as corolla tube, densely silky, the 2 upper teeth connate. Corolla blue to bluish white Vexillum orbicular-ovate 9- 16 mm long and 9-13 mm wide, base auriculate. Fruit 5-7.5 cm long, constricted between the seeds, densely pilose, hairs brown, silky, 3-6-seeded.
Habit/Life Form
Woody climber
DISTRIBUTION OF SPECIES IN INDIA
Uttarakhand, Jammu and Kashmir, Himachal Pradesh, Uttar Pradesh, West Bengal, Sikkim, Eastern India, Central India, Western Ghats & Eastern Ghats, Northeast and Rajasthan.
AGROCLIMATIC CONDITIONS
| # | Soil and Climate | Temperature (°C) | Average Annual Rainfall (mm) |
|---|---|---|---|
| 1 | Grows well in Sub-tropical climate and warm humid conditions. Prefers loam to sandy loam soil, rich in organic matter.It prefers moist soil and requires a sunny position in a well-drained soil .It ca | 27 | 800-4000 |
Local Names
| # | Language Name | Local Name |
|---|---|---|
| 1 | Malayalam | Muthukku |
| 2 | Marathi | Bharda, Bhebdar Veela, Birmalo, Godha Bael |
| 3 | Tamil | Darigummadi |
| 4 | Telugu | Darigummadi, Gummadi, Vidhaarikanda |
| 5 | Kannada | Bhoochakra gedde, Bidrerakanda, Gumadi gida |
| 6 | Oriya | Bhui, Bhui kumra, Patal Kumra, Mardamal |
| 7 | Gujrati | Bhoikolu, Bhonykoru, Eagio |
| 8 | Punjabi | Siali, Surala |
| 9 | Bengali | Bhuinkumra, Vidari |
International Local Names
| # | Country Name | Local Name |
|---|---|---|
| 1 | Nepal | Biralikund |
| 2 | Pakistan | Sarar, Sarwala, Siali, Surar (Urdu) |
Plant Parts Used
Tuber
System of Medicine
Ayurveda, Unani, Sowa Rigpa, Folk
Intended Use
Sexual weakness, inflammation and as a contraceptive agent, cardiotonic, diuretic, arthritis, burning sensation, constipation, cardiac debility, hepatosplenomegaly, leprosy, dyspepsia, spermatorrhea, tuberculosis, pharyngitis, and cough galactagogue. arthritis, burning sensation, constipation, cardiac debility, hepatosplenomegaly, leprosy, dyspepsia, spermatorrhea, tuberculosis, pharyngitis and cough, fertility disorders, general weakness and to relieve the symptoms of dysmenorrhea, uterine bleeding and menopausal syndrome.
Traditional Application
1) Tuber is primarily used in combination with cow’s milk as a galactagogue agent to abrogate the lack of milk production after childbirth
2) Tuber powder anabolic agent with Piper longum L. powder is used to cure malnutrition in children.
3) In excessive menstruation, the powder is used with honey.
4) Powdered tuber of P. tuberosa and wheat or barley fried in ghee (clarified butter) is advised to be consumed with milk for sexual enervation and strength.
5) For spermatorrhoea, fresh tuber juice of this plant with cumin seeds and sugar has been used. (Puri H. S. (2003). Rasayana: Ayurvedic Herbs for Longevity and Rejuvenation. 3 (2), (Hoboken, NJ: CRC Press; ). 303–307. ) (Bharti R, Chopra BS, Raut S, Khatri N. Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry. Frontiers in Pharmacology. 2020 ;11:582506. DOI: 10.3389/fphar.2020.582506. PMID: 33708108; PMCID: PMC7941752.)
5) Locally known as Bhoochakra in Seshachalam Biosphere Reserve in Eastern Ghats, India the tuber is used to cure asthma and act as a rejuvenator. (ARAVEETI MADHUSUDHANA REDDY1 *, MADHA VENKATA SURESH BABU, RAMACHANDRA RAGHAVENDRA RAO, Ethnobotanical study of traditional herbal plants used by local people of Seshachalam Biosphere Reserve in Eastern Ghats, India, the international journal edited by the Institute of Natural Fibres and Medicinal Plants,Vol. 65 No. 1 2019,DOI: 10.2478/hepo-2019-0006)
6) Identified as Bhuikakharu among Tribals of Mayurbhanj District of North Orissa, roots are crushed and applied on joints to treat rheumatism(S.D. Rout, T. Panda, and N. Mishra, Ethno-medicinal Plants Used to Cure Different Diseases by Tribals of Mayurbhanj District of North Orissa, Ethno-Med, 3(1): 27-32 (2009)).
7) Tubers grinded with Cissus quandrangularis, red onion, and Ginger and fermented in water for three days and given with rice-soaked water one liter per day for tuberculosis and motions.(E.N. Murthy, Ch. Sudhakar Reddy, K.N. Reddy & Vatsavaya S. Raju, Plants Used in Ethnoveterinary Practices by Koyas of Pakhal Wildlife Sanctuary, Andhra Pradesh, India, Ethnobotanical Leaflets 11: 1-5. 2007.)
8) Residents of Himachal Pradesh uses pueraria tuberosa to treat various ailments i.e Abdominal pain, antiemetic, asthma, body ache, chest pain, cholera, diarrhea, fever, lactation (S. S. Samant, Shreekar Pant, Man Singh, Manohar Lal, Ashok Singh, Aman Sharma and Sakshi Bhandari, Medicinal plants in Himachal Pradesh, north-western Himalaya, India, International Journal of Biodiversity Science and Management 3 (2007) 234–251)
9) Strengthens male reproductive system.
10) Soothes throat and is used to improve voice quality.
11) Used to remove extra cough and expectorant activity.
12) Promotes bile secretion. renal complaints.
13) Two tablespoons of tuber powder with mixed with one spoon of clarified butter consumed with milk is advised to strengthen semen.
14) 5g of tuber powder with water in the morning hours is beneficial in liver spleen enlargement.
15) Vidarikand powder with honey in the morning and evening can be helpful in ending the weakness of children.
Phytochemical Details
| # | Phytochemical Constituents | PUBCHEM CID | References |
|---|---|---|---|
| 1 | Puerarin | 5281807 | Chauhan, Sateesh Kumar et al. “Determination of puerarin from pueraria tuberosa dc by HPLC.” Ancient science of life vol. 23,3 (2004): 22-5. Patel I.C., Hakim M., Prajapati R., Solanki A., Panigrahi J. (2021) In Vitro Approach and Quantification of “Puerarin and Genistein”: Valuable Antidiabetic Compounds from Pueraria tuberosa. In: Gantait S., Verma S.K., Sharangi A.B. (eds) Biotechnology of Anti-diabetic Medicinal Plants. Springer, Singapore. https://doi.org/10.1007/978-981-16-3529-8_1 Zhang L. Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine. Drug Deliv. 2019 Dec;26(1):860-869. doi: 10.1080/10717544.2019.1660732. PMID: 31524010; PMCID: PMC6758605. Jeon YD, Lee JH, Lee YM, Kim DK. Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model. Biomed Pharmacother. 2020 Apr;124:109847. doi: 10.1016/j.biopha.2020.109847. Epub 2020 Jan 22. PMID: 31981944. Maji AK, Maity N, Banerji P, Banerjee D. A validated RP-HPLC-UV method for quantitative determination of puerarin in Pueraria tuberosa DC tuber extract. Pharm Methods. 2012 Jul;3(2):79-83. doi: 10.4103/2229-4708.103879. PMID: 23781483; PMCID: PMC3658094. Wang S, Zhang S, Wang S, Gao P, Dai L. A comprehensive review on Pueraria: Insights on its chemistry and medicinal value. Biomed Pharmacother. 2020 Nov;131:110734. doi: 10.1016/j.biopha.2020.110734. Epub 2020 Sep 15. PMID: 32942158. Wei SY, Chen Y, Xu XY. Progress on the pharmacological research of puerarin: a review. Chin J Nat Med. 2014 Jun;12(6):407-14. doi: 10.1016/S1875-5364(14)60064-9. PMID: 24969520. Zhang G, Wang Y, Tang G, Ma Y. Puerarin inhibits the osteoclastogenesis by inhibiting RANKL-dependent and -independent autophagic responses. BMC Complement Altern Med. 2019 Oct 15;19(1):269. doi: 10.1186/s12906-019-2691-5. PMID: 31615565; PMCID: PMC6794871. |
| 2 | Daidzein | 5281708 | Zhang L. Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine. Drug Deliv. 2019 Dec;26(1):860-869. doi: 10.1080/10717544.2019.1660732. PMID: 31524010; PMCID: PMC6758605. S Goyal , KG Ramawa , Isoflavonoids production in cell suspension cultures of Pueraria tuberosa grown in shake flasks and bioreactor,Planta Med 2008; 74 - PG67 DOI: 10.1055/s-0028-1084819 Kamlesh Vaishnav, Shaily Goyal & K G Ramawat,Isoflavonoids production in callus culture of Pueraria tuberosa, the Indian kudzu,Indian Journal of Experimental Biology Vol. 44, December 2006, pp. 1012-1017 Satpathy, Swaha & Patra, Arjun & Hussain, Muhammad & Ahirwar, Bharti. (2017). Simultaneous Estimation of Genistein and Daidzein in Pueraria Tuberosa (Willd.) DC by Validated High Performance Thin Layer Chromatography (HPTLC) Densitometry Method. Journal of Liquid Chromatography & Related Technologies. 40. 10.1080/10826076.2017.1329743. Satpathy S, Patra A, Hussain MD, Kazi M, Aldughaim MS, Ahirwar B (2021) A fraction of Pueraria tuberosa extract, rich in antioxidant compounds, alleviates ovariectomized-induced osteoporosis in rats and inhibits growth of breast and ovarian cancer cells. PLoS ONE 16(1): e0240068. https://doi.org/10.1371/journal.pone.0240068 Chauhan NS, Sharma V, Thakur M, Christine Helena Frankland Sawaya A, Dixit VK. Pueraria tuberosa DC extract improves androgenesis and sexual behavior via FSH LH cascade. ScientificWorldJournal. 2013 Dec 30;2013:780659. doi: 10.1155/2013/780659. PMID: 24489512; PMCID: PMC3893017. Fu Y, Wang L, Duan Y, Zou L, Ye B. Facile synthesized SnO2 decorated functionalized graphene modified electrode for sensitive determination of daidzein. Talanta. 2017 Jun 1;168:1-9. doi: 10.1016/j.talanta.2017.03.006. Epub 2017 Mar 7. PMID: 28391825. Swaha Satpathy, Arjun Patra, M. Delwar Hussain & Bharti Ahirwar (2017) Simultaneous estimation of genistein and daidzein in Pueraria tuberosa (Willd.) DC by validated high-performance thin-layer chromatography (HPTLC) densitometry method, Journal of Liquid Chromatography & Related Technologies, 40:10, 499-505, DOI: 10.1080/10826076.2017.1329743 Vaishnav K, Goyal S, Ramawat KG. Isoflavonoids production in callus culture of Pueraria tuberosa, the Indian kudzu. Indian J Exp Biol. 2006 Dec;44(12):1012-7. PMID: 17176676. |
| 3 | Genistin | 5281377 | Ahuja A, Tyagi PK, Tyagi S, Kumar A, Kumar M, Sharifi-Rad J. Potential of Pueraria tuberosa (Willd.) DC. to rescue cognitive decline associated with BACE1 protein of Alzheimer's disease on Drosophila model: An integrated molecular modeling and in vivo approach. Int J Biol Macromol. 2021 May 15;179:586-600. doi: 10.1016/j.ijbiomac.2021.03.032. Epub 2021 Mar 9. PMID: 33705837. Kamlesh Vaishnav, Shaily Goyal & K G Ramawat,Isoflavonoids production in callus culture of Pueraria tuberosa, the Indian kudzu,Indian Journal of Experimental Biology Vol. 44, December 2006, pp. 1012-1017 |
| 4 | Genistein | 5280961 | Patel I.C., Hakim M., Prajapati R., Solanki A., Panigrahi J. (2021) In Vitro Approach and Quantification of “Puerarin and Genistein”: Valuable Antidiabetic Compounds from Pueraria tuberosa. In: Gantait S., Verma S.K., Sharangi A.B. (eds) Biotechnology of Anti-diabetic Medicinal Plants. Springer, Singapore. https://doi.org/10.1007/978-981-16-3529-8_1 Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Pueraria tuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928291 Satpathy S, Patra A, Hussain MD, Kazi M, Aldughaim MS, Ahirwar B (2021) A fraction of Pueraria tuberosa extract, rich in antioxidant compounds, alleviates ovariectomized-induced osteoporosis in rats and inhibits growth of breast and ovarian cancer cells. PLoS ONE 16(1): e0240068. https://doi.org/10.1371/journal.pone.0240068 Patel I.C., Hakim M., Prajapati R., Solanki A., Panigrahi J. (2021) In Vitro Approach and Quantification of “Puerarin and Genistein”: Valuable Antidiabetic Compounds from Pueraria tuberosa. In: Gantait S., Verma S.K., Sharangi A.B. (eds) Biotechnology of Anti-diabetic Medicinal Plants. Springer, Singapore. https://doi.org/10.1007/978-981-16-3529-8_1 Goyal, S., Ramawat, K.G. Ethrel treatment enhanced isoflavonoids accumulation in cell suspension cultures of Pueraria tuberosa, a woody legume. Acta Physiol Plant 30, 849 (2008). https://doi.org/10.1007/s11738-008-0190-2 Sharma, V., Goyal, S. & Ramawat, K.G. Increased puerarin biosynthesis during in vitro shoot formation in Pueraria tuberosa grown in growtek bioreactor with aeration. Physiol Mol Biol Plants 17, 87–92 (2011). https://doi.org/10.1007/s12298-011-0049-7 |
| 5 | 3-O-methylanhydrotuberosin | 23276528 | Pandey, N., Tripathi, Y.B. Antioxidant activity of tuberosin isolated from Pueraria tuberose Linn. J Inflamm 7, 47 (2010). https://doi.org/10.1186/1476-9255-7-47 Khan, R.A. (2011), An enzyme-mimetic chemical conversion and biogenetic outline for chemical marker pterocarponoid oxygen heterocycles from Kudzu vine. J. Heterocyclic Chem., 48: 168-175. https://doi.org/10.1002/jhet.497 |
| 6 | Puerarostan | - | R.S. Gupta, Rakhi Sharma, Aruna Sharma, Rakesh Choudhary, A.K. Bhatnager & Y.C. Joshi (2005) Antifertility Effects of Pueraria tuberosa. Root Extract in Male Rats, Pharmaceutical Biology, 42:8, 603-609, DOI: 10.1080/13880200490902491 |
| 7 | β-sitosterol | 222284 | |
| 8 | Biochanin A | 25203224 | Ram Bharti, Bhupinder Singh Chopra, Sachin Raut, Neeraj Khatri ,Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry,Front. Pharmacol., 27 January 2021 Khatri, Neeraj & Bharti, Ram. (2021). Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry. Frontiers in Pharmacology. 11. 10.3389/fphar.2020.582506. Nagendra Singh Chauhan, Vikas Sharma, Mayank Thakur, Alexandra Christine Helena Frankland Sawaya, V. K. Dixit, |
| 9 | Biochanin B | 5280378 | Ram Bharti, Bhupinder Singh Chopra, Sachin Raut, Neeraj Khatri, Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry,Front. Pharmacol., 27 January 2021 Khatri, Neeraj & Bharti, Ram. (2021). Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry. Frontiers in Pharmacology. 11. 10.3389/fphar.2020.582506. Nagendra Singh Chauhan, Vikas Sharma, Mayank Thakur, Alexandra Christine Helena Frankland Sawaya, V. K. Dixit, "Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade", The Scientific World Journal, vol. 2013, Article ID 780659, 8 pages, 2013. https://doi.org/10.1155/2013/780659 Shengguang Wang, Shiming Zhang, Shaoping Wang, Peng Gao, Long Dai, A comprehensive review on Pueraria: Insights on its chemistry and medicinal value, Biomedicine & Pharmacotherapy, Volume 131, 2020, 110734, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2020.110734. |
| 10 | Daidzin | 107971 | Swaha Satpathy, Arjun Patra, M. Delwar Hussain & Bharti Ahirwar (2017) Simultaneous estimation of genistein and daidzein in Pueraria tuberosa (Willd.) DC by validated high-performance thin-layer chromatography (HPTLC) densitometry method, Journal of Liquid Chromatography & Related Technologies, 40:10, 499-505, DOI: 10.1080/10826076.2017.1329743 Satpathy S, Patra A, Hussain MD, Kazi M, Aldughaim MS, Ahirwar B (2021) A fraction of Pueraria tuberosa extract, rich in antioxidant compounds, alleviates ovariectomized-induced osteoporosis in rats and inhibits growth of breast and ovarian cancer cells. PLoS ONE 16(1): e0240068. https://doi.org/10.1371/journal.pone.0240068 Goyal, S., Ramawat, K.G. Ethrel treatment enhanced isoflavonoids accumulation in cell suspension cultures of Pueraria tuberosa, a woody legume. Acta Physiol Plant 30, 849 (2008). https://doi.org/10.1007/s11738-008-0190-2 Anami Ahuja, Pankaj Kumar Tyagi, Shruti Tyagi, Anuj Kumar, Manoj Kumar, Javad Sharifi-Rad, Potential of Pueraria tuberosa (Willd.) DC. to rescue cognitive decline associated with BACE1 protein of Alzheimer's disease on Drosophila model: An integrated molecular modeling and in vivo approach, International Journal of Biological Macromolecules, Volume 179, 2021, Pages 586-600, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2021.03.032. Vaishnav, Kamlesh,Goyal, Shaily,Ramawat, K G,Isoflavonoids production in callus culture of Pueraria tuberosa, the Indian kudzu,IJEB Vol.44(12) [December 2006] |
| 11 | Irisolidone | 5281781 | Zhang G, Gong T, Kano Y, Yuan D. Screening for in vitro metabolites of kakkalide and irisolidone in human and rat intestinal bacteria by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 1;947-948:117-24. doi: 10.1016/j.jchromb.2013.12.017. Epub 2013 Dec 25. PMID: 24412694. Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Puerariatuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928291 Bharti R, Chopra BS, Raut S, Khatri N. Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry. Front Pharmacol. 2021 Jan 27;11:582506. doi: 10.3389/fphar.2020.582506. PMID: 33708108; PMCID: PMC7941752. Kang GD, Lee SY, Jang SE, Han MJ, Kim DH. Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils. Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600517. Epub 2016 Oct 5. PMID: 27546737. Jang HM, Park KT, Noh HD, Lee SH, Kim DH. Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population. Int Immunopharmacol. 2019 Aug;73:246-253. doi: 10.1016/j.intimp.2019.05.008. Epub 2019 May 18. PMID: 31112869. Zhang G, Sun J, Kano Y, Yuan D. Metabolic profile of irisolidone in rats obtained by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 15;941:1-9. doi: 10.1016/j.jchromb.2013.09.033. Epub 2013 Oct 7. PMID: 24184829. Zhang G, Gong T, Kano Y, Yuan D. Screening for in vitro metabolites of kakkalide and irisolidone in human and rat intestinal bacteria by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 1;947-948:117-24. doi: 10.1016/j.jchromb.2013.12.017. Epub 2013 Dec 25. PMID: 24412694. |
| 12 | 4-Methoxypuerarin | 5319486 | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Puerariatuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928292 |
| 13 | Puerarone | - | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Puerariatuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928293 Bharti R, Chopra BS, Raut S, Khatri N. Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry. Front Pharmacol. 2021 Jan 27;11:582506. doi: 10.3389/fphar.2020.582506. PMID: 33708108; PMCID: PMC7941752. Pandey, N., Tripathi, Y.B. Antioxidant activity of tuberosin isolated from Pueraria tuberose Linn. J Inflamm 7, 47 (2010). https://doi.org/10.1186/1476-9255-7-47 |
| 14 | Quercetin | 5280343 | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Puerariatuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928294 |
| 15 | Robinin | 5281693 | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Puerariatuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928294 |
| 16 | Puerarostan | - | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Puerariatuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928294 |
| 17 | Epoxychalcanol (puetuberosanol) | - | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Puerariatuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928294 |
| 18 | Tuberosin | 14630495 | Balawant Shankar Joshi and Venkatesh Narsinh Kamat ,Tuberosin, a new pterocarpan from Pueraria tuberosa DC, J. Chem. Soc., Perkin Trans. 1, 1973, 907-911 Maji AK, Pandit S, Banerji P, Banerjee D. Pueraria tuberosa: a review on its phytochemical and therapeutic potential. Nat Prod Res. 2014;28(23):2111-27. doi: 10.1080/14786419.2014.928291. Epub 2014 Jul 1. PMID: 24980468. |
| 19 | Isoorientin | 114776 | Sumalatha M, Munikishore R, Rammohan A, Gunasekar D, Kumar KA, Reddy KK, Azad R, Reddanna P, Bodo B. Isoorientin, a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. Nat Prod Commun. 2015 Oct;10(10):1703-4. PMID: 26669106. |
Pharmacological Details
| # | PHARMACOLOGICAL ACTIONS/THERAPEUTIC USES | REFERENCES |
|---|---|---|
| 1 | Nephroprotective Activity | Shukla R, Banerjee S, Tripathi YB. Pueraria tuberosa extract inhibits iNOS and IL-6 through suppression of PKC-α and NF-kB pathway in diabetes-induced nephropathy. J Pharm Pharmacol. 2018 Aug;70(8):1102-1112. doi: 10.1111/jphp.12931. Epub 2018 May 16. PMID: 29770444. Yoon J, Lee H, Chang HB, Choi H, Kim YS, Rho YK, Seong S, Choi DH, Park D, Ku B. DW1029M, a novel botanical drug candidate, inhibits advanced glycation end-product formation, rat lens aldose reductase activity, and TGF-β1 signaling. Am J Physiol Renal Physiol. 2014 May 15;306(10):F1161-70. doi: 10.1152/ajprenal.00651.2013. Epub 2014 Apr 2. PMID: 24694590. Tripathi YB, Nagwani S, Mishra P, Jha A, Rai SP. Protective effect of Pueraria tuberosa DC. embedded biscuit on cisplatin-induced nephrotoxicity in mice. J Nat Med. 2012 Jan;66(1):109-18. doi: 10.1007/s11418-011-0559-1. Epub 2011 Jun 30. PMID: 21717089. Shukla R, Banerjee S, Tripathi YB. Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats. BMC Complement Altern Med. 2018 May 11;18(1):156. doi: 10.1186/s12906-018-2221-x. PMID: 29751837; PMCID: PMC5948837. Xu X, Zheng N, Chen Z, Huang W, Liang T, Kuang H. Puerarin, isolated from Pueraria lobata (Willd.), protects against diabetic nephropathy by attenuating oxidative stress. Gene. 2016 Oct 15;591(2):411-6. doi: 10.1016/j.gene.2016.06.032. Epub 2016 Jun 16. PMID: 27317894. |
| 2 | Antioxidant Activity | Satpathy S, Patra A, Hussain MD, Kazi M, Aldughaim MS, Ahirwar B. A fraction of Pueraria tuberosa extract, rich in antioxidant compounds, alleviates ovariectomized-induced osteoporosis in rats and inhibits the growth of breast and ovarian cancer cells. PLoS One. 2021 Jan 14;16(1):e0240068. doi: 10.1371/journal.pone.0240068. PMID: 33444328; PMCID: PMC7808586. Shukla R, Banerjee S, Tripathi YB. Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats. BMC Complement Altern Med. 2018 May 11;18(1):156. doi: 10.1186/s12906-018-2221-x. PMID: 29751837; PMCID: PMC5948837. Meng X, Tang GY, Liu PH, Zhao CJ, Liu Q, Li HB. Antioxidant activity and hepatoprotective effect of 10 medicinal herbs on CCl4-induced liver injury in mice. World J Gastroenterol. 2020 Oct 7;26(37):5629-5645. doi: 10.3748/wjg.v26.i37.5629. PMID: 33088157; PMCID: PMC7545387. Jeon YD, Lee JH, Lee YM, Kim DK. Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model. Biomed Pharmacother. 2020 Apr;124:109847. doi: 10.1016/j.biopha.2020.109847. Epub 2020 Jan 22. PMID: 31981944. Jeon YD, Lee JH, Lee YM, Kim DK. Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model. Biomed Pharmacother. 2020 Apr;124:109847. doi: 10.1016/j.biopha.2020.109847. Epub 2020 Jan 22. PMID: 31981944. Wang S, Zhang S, Wang S, Gao P, Dai L. A comprehensive review on Pueraria: Insights on its chemistry and medicinal value. Biomed Pharmacother. 2020 Nov;131:110734. doi: 10.1016/j.biopha.2020.110734. Epub 2020 Sep 15. PMID: 32942158. Pandey N, Yadav D, Pandey V, Tripathi YB. Anti-inflammatory effect of Pueraria tuberosa extracts through improvement in activity of red blood cell anti-oxidant enzymes. Ayu. 2013 Jul;34(3):297-301. doi: 10.4103/0974-8520.123131. PMID: 24501527; PMCID: PMC3902598. Huang Q, Zhang H, Xue D. Enhancement of antioxidant activity of Radix Puerariae and red yeast rice by mixed fermentation with Monascus purpureus. Food Chem. 2017 Jul 1;226:89-94. doi: 10.1016/j.foodchem.2017.01.021. Epub 2017 Jan 6. PMID: 28254024. Verma SK, Jain V, Singh DP. Effect of Pueraria tuberosa DC. (Indian Kudzu) on blood pressure, fibrinolysis and oxidative stress in patients with stage 1 hypertension. Pak J Biol Sci. 2012 Aug 1;15(15):742-7. doi: 10.3923/pjbs.2012.742.747. PMID: 24171260. Jin SE, Son YK, Min BS, Jung HA, Choi JS. Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. Arch Pharm Res. 2012 May;35(5):823-37. doi: 10.1007/s12272-012-0508-x. Epub 2012 May 29. PMID: 22644850. Dong Z, Zhang M, Li H, Zhan Q, Lai F, Wu H. Structural characterization and immunomodulatory activity of a novel polysaccharide from Pueraria lobata (Willd.) Ohwi root. Int J Biol Macromol. 2020 Jul 1;154:1556-1564. doi: 10.1016/j.ijbiomac.2019.11.040. Epub 2019 Nov 13. PMID: 31733238. Zhou H, Li X, Shang Y, Chen K. Radical Scavenging Activity of Puerarin: A Theoretical Study. Antioxidants (Basel). 2019 Nov 26;8(12):590. doi: 10.3390/antiox8120590. PMID: 31779233; PMCID: PMC6943502. Chang HJ, Kim YH, Kang YH, Choi MH, Lee JH. Antioxidant and antibacterial effects of medicinal plants and their stick-type medicinal concentrated beverages. Food Sci Biotechnol. 2020 Aug 5;29(10):1413-1423. doi: 10.1007/s10068-020-00793-9. PMID: 32999749; PMCID: PMC7492349. Srivastava S, Pandey H, Singh SK, Tripathi YB. Anti-oxidant, anti-apoptotic, anti-hypoxic and anti-inflammatory conditions induced by PTY-2 against STZ-induced stress in islets. Biosci Trends. 2019 Nov 13;13(5):382-393. doi: 10.5582/bst.2019.01181. Epub 2019 Oct 8. PMID: 31597821. |
| 3 | Antidiabetic Activity | Tripathi YB, Shukla R, Pandey N, Pandey V, Kumar M. An extract of Pueraria tuberosa tubers attenuates diabetic nephropathy by upregulating matrix metalloproteinase-9 expression in the kidney of diabetic rats. J Diabetes. 2017 Feb;9(2):123-132. doi: 10.1111/1753-0407.12393. Epub 2016 Apr 13. PMID: 26924185. Srivastava S, Shree P, Pandey H, Tripathi YB. Incretin hormone receptor signaling plays the key role in the antidiabetic potential of PTY-2 against STZ-induced pancreatitis. Biomed Pharmacother. 2018 Jan;97:330-338. doi: 10.1016/j.biopha.2017.10.071. Epub 2017 Nov 6. Erratum in: Biomed Pharmacother. 2018 Nov;107:1795. PMID: 29091882. |
| 4 | Anti-Inflammatory Activity | Pandey N, Yadav D, Pandey V, Tripathi YB. Anti-inflammatory effect of Pueraria tuberosa extracts through improvement in activity of red blood cell antioxidant enzymes. Ayu. 2013 Jul;34(3):297-301. doi: 10.4103/0974-8520.123131. PMID: 24501527; PMCID: PMC3902598. Srivastava S, Pandey H, Singh SK, Tripathi YB. Anti-oxidant, anti-apoptotic, anti-hypoxic and anti-inflammatory conditions induced by PTY-2 against STZ-induced stress in islets. Biosci Trends. 2019 Nov 13;13(5):382-393. doi: 10.5582/bst.2019.01181. Epub 2019 Oct 8. PMID: 31597821. Bharti R, Chopra BS, Raut S, Khatri N. Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry. Front Pharmacol. 2021 Jan 27;11:582506. doi: 10.3389/fphar.2020.582506. PMID: 33708108; PMCID: PMC7941752. Mahdy HM, Mohamed MR, Emam MA, Karim AM, Abdel-Naim AB, Khalifa AE. The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid-induced neurotoxicity in rats. Can J Physiol Pharmacol. 2014 Mar; 92(3): 252-8. doi: 10.1139/cjpp-2013-0398. Epub 2014 Jan 8. Erratum in: Can J Physiol Pharmacol. 2014 May; 92(5):427. Abdel-Naim, Ashraf [corrected to Abdel-Naim, Ashraf B]. PMID: 24593790. Singh AK, Jiang Y, Gupta S, Younus M, Ramzan M. Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. J Med Food. 2013 Oct;16(10):899-911. doi: 10.1089/jmf.2012.0049. PMID: 24138167. Cheung DW, Koon CM, Wat E, Ko CH, Chan JY, Yew DT, Leung PC, Chan WY, Lau CB, Fung KP. A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages through inhibition of the nuclear factor κB (NFκB) pathway. J Ethnopharmacol. 2013 Feb 13;145(3):776-83. doi: 10.1016/j.jep.2012.12.011. Epub 2012 Dec 20. PMID: 23261483. Zhu WF, Li JL, Meng XW, Zhang PZ, Wu WT, Liu RH. [Research advances in chemical constituents and pharmacological activities of Pueraria genus]. Zhongguo Zhong Yao Za Zhi. 2021 Mar;46(6):1311-1331. Chinese. doi: 10.19540/j.cnki.cjcmm.20201124.601. PMID: 33787127. Bulugonda RK, Kumar KA, Gangappa D, Beeda H, Philip GH, Muralidhara Rao D, Faisal SM. Mangiferin from Pueraria tuberosa reduces inflammation via the inactivation of NLRP3 inflammasome. Sci Rep. 2017 Feb 20;7:42683. doi: 10.1038/srep42683. PMID: 28218280; PMCID: PMC5316935. |
| 5 | Anti-Stress Activity | Bharti R, Chopra BS, Raut S, Khatri N. Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry. Front Pharmacol. 2021 Jan 27;11:582506. doi: 10.3389/fphar.2020.582506. PMID: 33708108; PMCID: PMC7941752. |
| 6 | Immunomodulatory Activity | Patel, Jignesh & Doshi, Nitin & Bhalerao, Abheejit & Bonagiri, Rajesh. (2016). Immunomodulatory activity of ethanolic extract of Pueraria Tuberosa D.C. International Journal of Scientific & Engineering Research. 7. 708. Dong Z, Zhang M, Li H, Zhan Q, Lai F, Wu H. Structural characterization and immunomodulatory activity of a novel polysaccharide from Pueraria lobata (Willd.) Ohwi root. Int J Biol Macromol. 2020 Jul 1;154:1556-1564. doi: 10.1016/j.ijbiomac.2019.11.040. Epub 2019 Nov 13. PMID: 31733238. Sawale, P.D., Singh, R.R.B., Kapila, S., Arora, S., Rastogi, S. and Rawat, A.K.S. (2013), Immunomodulatory and antioxidative potential of herb (Pueraria tuberosa) in mice using milk as the carrier. Int J Dairy Technol, 66: 202-206. https://doi.org/10.1111/1471-0307.12011 |
| 7 | Anticancer Activity | Bharti R, Chopra BS, Raut S, Khatri N. Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry. Front Pharmacol. 2021 Jan 27;11:582506. doi: 10.3389/fphar.2020.582506. PMID: 33708108; PMCID: PMC7941752. Ahmad B, Khan S, Liu Y, Xue M, Nabi G, Kumar S, Alshwmi M, Qarluq AW. Molecular Mechanisms of Anticancer Activities of Puerarin. Cancer Manag Res. 2020 Jan 8;12:79-90. doi: 10.2147/CMAR.S233567. PMID: 32021425; PMCID: PMC6956866. Satpathy S, Patra A, Ahirwar B, Delwar Hussain M. Antioxidant and anticancer activities of green synthesized silver nanoparticles using aqueous extract of tubers of Pueraria tuberosa. Artif Cells Nanomed Biotechnol. 2018;46(sup3):S71-S85. doi: 10.1080/21691401.2018.1489265. Epub 2018 Jul 25. PMID: 30043665. |
| 8 | Hyperplasia | Mohamad J, Masrudin SS, Alias Z, Muhamad NA. The effects of Pueraria mirifica extract, diadzein and genistein in testosterone-induced prostate hyperplasia in male Sprague Dawley rats. Mol Biol Rep. 2019 Apr;46(2):1855-1871. doi: 10.1007/s11033-019-04638-5. Epub 2019 Feb 1. PMID: 30710233. Masrudin SS, Mohamad J. Preventive effect of Pueraria mirifica on testosterone-induced prostatic hyperplasia in Sprague Dawley rats. Andrologia. 2015 Dec;47(10):1153-9. doi: 10.1111/and.12396. Epub 2015 Jan 20. PMID: 25600492. Jiang B, Yang W, Chen L, Wang S, Chen S, Bao Y, Chen Q, Wang Q, Asakawa T. In vitro effects of Pueraria extract on ethanol-exposed microglia and neurons. Biomed Pharmacother. 2020 Jul;127:110163. doi: 10.1016/j.biopha.2020.110163. Epub 2020 May 4. PMID: 32380388. Wang AX, Zhu XY, Huang T, Yang J, Cheng YD, Xu YF. [Effects of Kudzu Root plus Cinnamon Granules on prostatic hyperplasia in mice]. Zhonghua Nan Ke Xue. 2017 Apr;23(4):353-360. Chinese. PMID: 29714422. Kakehashi A, Yoshida M, Tago Y, Ishii N, Okuno T, Gi M, Wanibuchi H. Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats. Toxins (Basel). 2016 Nov 4;8(11):275. doi: 10.3390/toxins8110275. PMID: 27827907; PMCID: PMC5127102. |
| 9 | Fertility disorders | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Pueraria tuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928291 |
| 10 | Menopausal syndrome/ Contraceptive potency | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Pueraria tuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928292 Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacol Rev. 2016 Oct;68(4):1026-1073. doi: 10.1124/pr.115.010843. PMID: 27677719; PMCID: PMC5050441. Prakash AO, Saxena V, Shukla S, Mathur R. Contraceptive potency of Pueraria tuberosa D.C. and its hormonal status. Acta Europaea Fertilitatis. 1985 Jan-Feb;16(1):59-65. PMID: 4013619. Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacol Rev. 2016 Oct;68(4):1026-1073. doi: 10.1124/pr.115.010843. PMID: 27677719; PMCID: PMC5050441. |
| 11 | Sexual debility | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Pueraria tuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928293 |
| 12 | Spermatorrhoea | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Pueraria tuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928294 |
| 13 | Hepatosplenomegaly | Amal K. Maji, Subrata Pandit, Pratim Banerji & Debdulal Banerjee (2014) Pueraria tuberosa: a review on its phytochemical and therapeutic potential, Natural Product Research, 28:23, 2111-2127, DOI: 10.1080/14786419.2014.928295 |
| 14 | Aphrodisiac | Nagendra Singh Chauhan, Vikas Sharma, Mayank Thakur ,Alexandra Christine Helena Frankland Sawaya, and V. K. Dixit, Pueraria tuberosa DC Extract Improves Androgenesis and Sexual Behavior via FSH LH Cascade,The Scientific World Journal PB - Hindawi Publishing Corporation,Volume 2013 |Article ID 780659 | https://doi.org/10.1155/2013/780659 Nilambari Gurav, Shailendra Gurav, Manish Wanjari, Satyendra Prasad, Sandesh Wayal, Nilesh Rarokar, Development and evaluation of the aphrodisiac potential of a classical ayurvedic formulation, ‘Kaamdev ghrita’ in the rat model, Journal of Ayurveda and Integrative Medicine, Volume 12, Issue 2,2021, Pages 294-301, ISSN 0975-9476, https://doi.org/10.1016/j.jaim.2020.09.007. (https://www.sciencedirect.com/science/article/pii/S0975947620300991) |
| 15 | Hepatoprotective activity | Shukla, S., Jonathan, S. and Sharma, A. (1996), Protective Action of Butanolic Extract of Pueraria tuberosa DC. Against Carbon Tetrachloride Induced Hepatotoxicity in Adult Rats. Phytother. Res., 10: 608-609. https://doi.org/10.1002/(SICI)1099-1573(199611)10:7<608::AID-PTR842>3.0.CO;2-1 Adedapo AA, Fagbohun OA, Dawurung C, Oyagbemi AA, Omobowale TO, Yakubu MA. The aqueous tuber extract of Pueraria tuberosa (Willd.) D.C. caused cytotoxic effect on HT 29 cell lines with down regulation of nuclear factor-kappa B (NF-κB). J Complement Integr Med. 2017 Oct 18;16(4):/j/jcim.2019.16.issue-4/jcim-2016-0119/jcim-2016-0119.xml. doi: 10.1515/jcim-2016-0119. PMID: 29045235. Harsh Pandey, Shivani Srivastava, Yamini Bhusan Tripathi,Herbal tablet of Pueraria tuberosa water extract suppresses the alloxan induced liver damage and hyperglycemia in rats,bioRxiv 671594; doi: https://doi.org/10.1101/671594 |
| 16 | Cardioprotective effects | Verma SK, Jain V, Singh DP. Effect of Pueraria tuberosa DC. (Indian Kudzu) on blood pressure, fibrinolysis and oxidative stress in patients with stage 1 hypertension. Pakistan Journal of Biological Sciences: PJBS. 2012 Aug;15(15):742-747. DOI: 10.3923/pjbs.2012.742.747. PMID: 24171260. S. K. Verma, V. Jain, A. Vyas and D. P. Singh, PROTECTION AGAINST STRESS INDUCED MYOCARDIAL ISCHEMIA BY INDIAN KUDZU (PUERARIA TUBEROSA) – A CASE STUDY, Journal of Herbal Medicine and Toxicology 3 (1) 59-63 (2009) ISSN: 0973-4643 |
| 17 | Anticonvulsant activity | Basavaraj, P; Shivakumar, B; Shivakumar, H., EVALUATION OF ANTICONVULSANT ACTIVITY OF ALCOHOLIC EXTRACT OF TUBERS OF PUERARIA TUBEROSA (ROXB) Advances in Pharmacology and Toxicology; Jalgaon Vol. 12, Iss. 1, (Apr 2011): 1-9. Bharti Ram, Chopra Bhupinder Singh, Raut Sachin, Khatri Neeraj, Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry, Front. Pharmacol., 27 January 2021 | https://doi.org/10.3389/fphar.2020.582506 |
| 18 | Nootropic activity | Rao NV, Pujar B, Nimbal SK, Shantakumar SM, Satyanarayana S. 2008. Nootropic activity of tuber extract of Pueraria tuberosa (Roxb). Indian J Exp Biol. 46:591–598 Xing G, Dong M, Li X, Zou Y, Fan L, Wang X, Cai D, Li C, Zhou L, Liu J, Niu Y. 2011. Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. Brain Res Bull. 85:212– 218. Kim DH, Jung HA, Park SJ, Kim JM, Lee S, Choi JS, Cheong JH, Ko KH, Ryu JH. 2010. The effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice. Arch Pharm Res. 33:1685–1690. Bagheri M, Joghataei MT, Mohseni S, Roghani M. 2011. Genistein ameliorates learning and memory deficits in amyloid b(1–40) rat model of Alzheimer’s disease. Neurobiol Learn Mem. 95:270–276. |
| 19 | Wound healing activity | Kambhoja S, Murthy KRK. 2007. Wound healing and anti-inflammatory activity of Pueraria tuberosa (Roxb Ex wild) DC. Biomed. 2:229–232 Emmerson E, Campbell L, Ashcroft GS, Hardman MJ. 2010. The phytoestrogen genistein promotes wound healing by multiple independent mechanisms. Mol Cell Endocrinol. 321:184 –193. Mukai K, Nagasawa M, Nakamura E, Nishida N, Hori A, Yagi Y, Yamagishi A, Watanabe A, Urai T, Takada K, et al.2012. The effect of isoflavone-daidzein oral medication on cutaneous wound healing in female ovariectomized mice. Struct Func. 10:94–100 |
| 20 | Antihypertensive effect | Song XP, Chen PP, Chai XS. 1988. Effect of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats. Acta Pharmacol Sin. 9:55–58. Palanisamy N, Venkataraman AC. 2013. Beneficial effect of genistein on lowering blood pressure and kidney toxicity in fructose-fed hypertensive rats. Br J Nutr. 109:1806–1812. Guo JP, Shun QR, Zhou H. 1995. The pharmacological progress of Radix puerariae. Chin Tradit Herb Drugs.26:163–165 |
| 21 | Fibrinolytic activity | Shen GX. 2003. Dyslipoproteinemia and fibrinolysis. In: Pierce G, Nagano M, Zahradka P, Dhalla NS, editors. Atherosclerosis, hypertension and diabetes. Boston: Kluwer Academic; p. 289 –300. Verma SK, Jain V, Vyas A, Singh DP. 2009. Protection against stress-induced myocardial ischemia by Indian kudzu (Pueraria tuberosa) – a case study. J Herb Med Toxicol. 3:59–63. Chen J, Xu J, Li J. 1999. Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease. Chin J Integr Tradit West Med. 19:649–650 Kelly LA, O’Leary JJ, Seidlova-Wuttke D, Wuttke W, Norris LA. 2010. Genistein alters coagulation gene expression in ovariectomized rats treated with phytoestrogens. Thromb Haemost. 104:1250–1257. |
| 22 | Antiapoptotic effect | Shukla R, Banerjee S, Tripathi YB. Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats. BMC Complement Altern Med. 2018 May 11;18(1):156. doi: 10.1186/s12906-018-2221-x. PMID: 29751837; PMCID: PMC5948837. |
Marketed Products
| # | AVALAIBLE PRODUCTS | MANUFACTURERS AND SUPPLIERS | URL |
|---|---|---|---|
| 1 | Bixa Botanical Vidarikand Root Powder | S A Herbal Bioactives LLP | Open Url |
| 2 | Vidarikand Powder | Planet Ayurveda | Open Url |
| 3 | Krishna's Herbal & Ayurveda Vidari kand (Pueraria tuberosa) Powder | KRISHNA'S HERBAL & AYURVEDA | Open Url |
| 4 | Heilen Biopharm Vidarikand Herbal Powder (Pueraria tuberosa) India Kudzu | HEILEN BIOPHARM | Open Url |
| 5 | Vyas Vidarikand Churna | Vyas | Open Url |
| 6 | Himalaya Chyavanprash Jam | The Himalaya Drug Company | Open Url |
| 7 | Indian Kudzu Root Powder | bixa BOTANICAL | Open Url |
| 8 | Vitacost Kudzu Root Extract | Vitacost Brand | Open Url |
| 9 | Swanson Kudzu Root | Swanson | Open Url |
| 10 | Kudzu Liquid Extract | FLORIDA HERBS | Open Url |
| 11 | Planetary Herbals Kudzu | Planetary Formulas | Open Url |
| 12 | Kudzu Tincture Alcohol-Free Liquid | Secrets Of The Tribe | Open Url |
| 13 | Gopichandanadi gulika | Vaidyaratnam P.S Varier's | Open Url |
| 14 | AVP Amruthaprasa Gritham | AVP | Open Url |
| 15 | Vidaryadyasavam | Kottakkal Arya Vaidya Sala | Open Url |
| 16 | Vimfix Tablet | Sandu Pharmaceuticals Pvt Ltd | Open Url |
Traditional Indian Medicinal Formulations
| # | AYURVEDIC FORMULATIONS (TKDL) | UNANI FORMULATIONS (TKDL) | SIDDHA FORMULATIONS (TKDL) |
|---|---|---|---|
| 1 | Masparnyadicurnam | Qissa- Ul- Himaar | |
| 2 | Dadimadyamghrtam | ||
| 3 | Jivkadyamodaka | ||
| 4 | Jivantyadyanuvasnam | ||
| 5 | Masatailam | ||
| 6 | Dasamuladighritam |
Other Polyherbal Formulations
| # | POLYHERBAL FORMULATIONS | CITATIONS ON POLYHERBAL FORMULATIONS (PROPERTIES & ACTIVITIES) |
|---|---|---|
| 1 | Panchendriya vivardhna Taila- Rani, Renu & Kori, Virendra & Patel, Ks & Harisha, Channappa & Shukla, Vinay. (2018). Pharmacognostical and Phytochemical Evaluation of Panchendriya vivardhna Taila -Polyherbal Formulation. 2555-58. | Gurav N, Gurav S, Wanjari M, Prasad S, Wayal S, Rarokar N. Development and evaluation of aphrodisiac potential of a classical ayurvedic formulation, 'Kaamdev ghrita' in rat model. J Ayurveda Integr Med. 2021 Apr-Jun;12(2):294-301. doi: 10.1016/j.jaim.2020.09.007. Epub 2020 Dec 17. PMID: 33342646; PMCID: PMC8185976. |
| 2 | Pandey, Harsh & Srivastava, Shivani & Tripathi, Yamini Bhusan. (2019). Herbal tablet of Pueraria tuberosa water extract suppresses the alloxan induced liver damage and hyperglycemia in rats. 10.1101/671594v1. |
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| 3 | Bhagirath Sankaliya, Dr. T. S. Dudhamal, Harisha C. R., and Shukla V. J, PHARMACOGNOSTICAL AND PHYTOCHEMICAL STANDARDIZATION OF USHIRADYA TAILA-AN AYURVEDICPOLYHERBAL FORMULATION, World Journal of Pharmaceutical Research, Vol 7, Issue 13, 2018 |
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| 4 | Tanna, I., Aghera, H., Ashok, B., and Chandola, H. (2012). Protective role of Ashwagandharishta and flax seed oil against maximal electroshock induced seizures in albino rats. Ayu. 33 (1), 114–118.doi:10.4103/0974-8520.100327 |
Market Overview
Global End Use Market
Pharmaceuticals, Folk uses
Available Global Market
India, Nepal
Global Manufacturer Extract
--
Distribution in IORA Countries
Bangladesh
Trade Data
Source Supply
Hillforests,dry and moist deciduous forest
Trade Name
Bidarikand, bidarikand white, bidarikhand kshveth, vidari kand, Patal kumbha
Annual Consumption (in MT)
--
Medicinal Plants Traders from India
| # | ADDRESSES OF MEDICINAL PLANTS TRADERS |
|---|---|
| 1 | VIVAAN HERBALS & HEALTHCARE ,D-31 A, Gallops Industrial Park, Chacharwadi, Ahmedabad, Gujarat, 382213, India catalog https://vivaanherbalsnhealthcare.tradeindia.com/ |
| 2 | SA Herbal Bioactives LLP Head Office Jairamdass Khushiram Building, Plot No: 5, Sector 19-C, Vashi, Navi Mumbai-400 703. Maharashtra, India. Landline: +91-22-2783 1232 / 8111 Mobile: +91-8591202602 Email: enquire@jairamdass.com |
| 3 | Xena bioherbals, 3-6-294, Hyderguda, Hyderabad - 500029, Telangana, India,prem@xenabioherbals.com Contact +91 9848425596 |
PATENTS
| # | PATENT TITLE | PATENT/APPLICATION NO. | PATENT OFFICE | SOURCE |
|---|---|---|---|---|
| 1 | Formulation for Prevention and Treatment of Bacterial Infections and Preparation Thereof | 20120034325 | USPTO | Details |
| 2 | Composition for treatment and management of addiction and method of preparation thereof | 20200023027 | USPTO | Details |
| 3 | COMPOSITION FOR PREVENTING OR TREATING POLIOSIS OR VITILIGO COMPRISING A PUERARIA GENUS PLANT EXTRACT OR PUERARIN | 20120329739 | USPTO | Details |
| 4 | Herbal nutraceutical formulation for diabetics and process for preparing the same | 20060147561 | USPTO | Details |
| 5 | Herbal extract and compound lupinoside and its analogues as anti-diabetic type II drugs from plant pueraria tuberosa | 20050153000 | USPTO | Details |
| 6 | Custom made herbal health promotive formulation for females/expectant mothers | 20040219235 | USPTO | Details |
| 7 | Herbal health protective and promotive nutraceutical formulation for diabetics and process for preparing the same | 20030185913 | USPTO | Details |
| 8 | Custom made herbal health protective nutraceutical formulation for females/expectant mothers and process for preparing the same | 20030129258 | USPTO | Details |
| 9 | COMPOSITION FOR FRACTURE HEALING | - | IPO | Details |
| 10 | SIZING AGENT FOR TEXTILE APPLICATIONS AND A METHOD FOR EXTRACTING THE SAME FROM LUFFA TUBEROSA TUBERS | - | IPO | Details |
| 11 | A NOVEL GALACTAGOGUE NUTRACEUTICAL SUPPLEMENT | - | IPO | Details |
| 12 | HERBAL COMPOSITION FOR TREATMENT OF HYPERTENSION AND ASSOCIATED DISORDERS | 3507/MUM/2013 | IPO | Details |
| 13 | HERBAL FORMULATION FOR MENSTRUAL DISORDER | 1074/KOL/2012 | IPO | Details |
| 14 | A HERBAL FORMULATION FOR LEUCORRHOEA | 1073/KOL/2012 | IPO | Details |
| 15 | A HERBAL FORMULATION FOR TREATMENT OF TYPHOID FEVER AND PREPARATION THEREOF | 2775/DEL/2012 | IPO | Details |
| 16 | PELLETS OF HERBAL EXTRACTS AND PROCESS FOR PREPARING THE SAME | 602/MUM/2012 | IPO | Details |
| 17 | FORMULATION FOR PREVENTION AND TREATMENT OF BACTERIAL INFECTIONS AND PROCESS FOR PREPARATION THEREOF | 960/KOL/2009 | IPO | Details |
| 18 | A HERBAL PRODUCT, ISOLATED FROM PUERARIA TUBEROSA (ROXB.EX WILLD.) DC, WITH NOVEL PKC INHIBITOR PROPERTY, TO PREVENT DIABETIC NEPHROPATHY, RADIATION HAZARDS, AGE RELATED CHRONIC DISEASES AND AS GENERAL HEALTH TONIC | 2751/DEL/2008 | IPO | Details |
| 19 | HERBAL CATTLE FEED SUPPLEMENT COMPOSITIONS FOR ENHANCING PRODUCTIVITY AND QUALITY OF MILK BY IMPROVED BIOAVAILABILITY | 280/MUM/2008 | IPO | Details |
| 20 | A PROCESS FOR THE PREPARATION OF A HERBAL COMPOSITION' | 1057/DEL/1998 | IPO | Details |
Adulterant/Substitute
Ipomoea digitata Cycas circinalis is sold in name of Vidari. (P. tuberosa is identified by the presence of papery flake-like tubers and I. digitata by the presence of its concentric rings of vascular bundles (S.K.Mitra and R.Kannan, A Note on Unintentional Adulterations in Ayurvedic Herbs, Ethnobotanical Leaflets 11: 11-15. 2007