Aloe barbadensis Mill, Aloe barbadensis var. chinensis Haw., Aloe chinensis Steud. ex Baker, Aloe elongata Murray, Aloe flava Pers., Aloe indica Royle, Aloe lanzae Tod., Aloe perfoliata var. barbadensis (Mill.) Aiton, Aloe rubescens DC., Aloe variegata Forssk., Aloe vera var. chinensis, Aloe vera var. lanzae Baker, Aloe vera var. littoralis Aloe vulgaris Lam.
Kingdom
Plantae
Subkingdom
--
Superdivision
Spermatophyta
Division
Magnoliophyta
Class
Liliopsida (Monocotyledons)
Subclass
Order
Liliales
Family
Aloacease
Genus
Aloe L
Species
Aloe vera (L.) Burm. f.
Herb
Rajasthan, Gujarat, Madhya Pradesh, Maharashtra, Tamil nadu, Andhra Pradesh, Punjab, Andhra Pradesh, Arunachal Pradesh, Assam, Haryana, Jharkhand, Kerala, Manipur, Mizoram, Nagaland and Orissa
| # | Soil and Climate | Temperature (°C) | Average Annual Rainfall (mm) |
|---|---|---|---|
| 1 | It is grown successfully in marginal to sub marginal soils having low fertility, most species of Aloe typically grow in sandy soils, black cotton soil. | 25 – 40 | 500-1200 |
| # | Language Name | Local Name |
|---|---|---|
| 1 | Sanskrit | Kumarirasasambhava, Sahasara Assamese, Musabhar, Machambar Bengali, Ghritakalmi |
| 2 | English | Indain Aloe |
| 3 | Gujrati | Eliyo, Eariyo |
| 4 | Hindi | Musabhar, Elva |
| 5 | Kannada | Karibola, Lolesara Satva, Lovalsara, Lolesara |
| 6 | Kashmiri | Musabbar, Siber |
| 7 | Malayalam | Chenninayakam |
| 8 | Marathi | Korphad |
| 9 | Oriya | Musabara |
| 10 | Punjabi | Kalasohaga, Mussabar, Alua |
| 11 | Tamil | Kattazhi, Satthukkathazhai |
| 12 | Telungu | Musambaram |
| 13 | Urdu | Musabbar, Ailiva, Siber |
| # | Country Name | Local Name |
|---|---|---|
| 1 | English | Barbados Aloe, Bitter Aloe, Curacao Aloe, First Aid Plant, Medicinal Aloe |
| 2 | West India | Aloe |
| 3 | Bahamas | Bitter Aloes |
| 4 | Cuba | Cuba |
| 5 | Germany | Alo, Echte |
| 6 | Greece | Allas, Aloi |
| 7 | Haiti | Aloes Des Jardins, L`Alois |
| 8 | India | Cherukattazha, Gheekumari, Kathalai, Kattar Vazha, Khorpad, Jamaica, Sempervivum |
| 9 | Jamaica | Sempervivum |
| 10 | Lesser Antilles | Sentebibu, Sinkle Bible |
| 11 | Malta | Zabbara |
| 12 | Spain | Acibar, Zabila, Zabira |
| 13 | Spain | Acibar, Zabila, Zabila(Mexico) |
| 14 | French | Aloes, Officinal, Aloes Vrai, Aloes Vulgaire |
| 15 | Chinese | Iu Hui |
| 16 | Portuguese | Aloes-Dos-Barbados, Babosa-Medicinal, Erva-Barbadosa |
| 17 | Thailand | Wan Hang Chorakhe Yemen-sabbare |
Leaves and Aloe latex
Ayurveda, Unani, Siddha, Homoeopathy, Folk medicine, Traditional Chinese medicine
Coughs, wounds, ulcers, gastritis, Diabetes, Cancer, headaches, arthritis, immune-system deficiencies, heartburn, irritable bowel syndrome, ulcers, colitis, and colon-related problems. Insect bites, rashes, sores, herpes, urticaria, fungal infection, and vaginal infections, reduce psoriasis, reduce rosacea, reduce warts and reduce aging, reduce wrinkles, and also it reduces eczema.
| # | Country Name | Uses |
|---|---|---|
| 1 | Thailand | In Thailand aloe vera leaves are used as a laxative and on fresh wounds and skin burns. |
| 2 | South Africa | In South Africa-1-The leaves and roots of Aloe ferox are applied topically, sometimes mixed with animal fat, or taken internally to treat conditions such as eczema, dermatitis and acne. 2- The sap of Aloe ferox, Aloe hereroensis and Aloe littoralis is administered as eye drops (Watt, J.M., Breyer-Brandwijk,M.G., 1962.Medicinal and Poisonous Plants of Southern and Eastern Africa. E. & S. Livingstone, Edinburgh.) |
| # | Phytochemical Constituents | PUBCHEM CID | References |
|---|---|---|---|
| 1 | Aloe-emodin | https://pubchem.ncbi.nlm.nih.gov/compound/Aloe-emodin | |
| 2 | Chrysophanol | https://pubchem.ncbi.nlm.nih.gov/compound/Chrysophanol | |
| 3 | Aloesaponarin I | https://pubchem.ncbi.nlm.nih.gov/compound/Aloesaponarin-I | |
| 4 | Aloesaponarin II | https://pubchem.ncbi.nlm.nih.gov/compound/Aloesaponarin-II | |
| 5 | Helminthosporin | https://pubchem.ncbi.nlm.nih.gov/compound/Helminthosporin | |
| 6 | Aloin A (Barbaloin) | https://pubchem.ncbi.nlm.nih.gov/compound/Aloin-A | |
| 7 | Aloin B (Isobarbaloin) | https://pubchem.ncbi.nlm.nih.gov/compound/Aloin | |
| 8 | 5-hydroxyaloin A | https://pubchem.ncbi.nlm.nih.gov/compound/5-Hydroxyaloin-A | |
| 9 | 7-hydroxyaloin B | https://pubchem.ncbi.nlm.nih.gov/compound/7-Hydroxyaloin | |
| 10 | Microdontin A | https://pubchem.ncbi.nlm.nih.gov/compound/101629131 | |
| 11 | Microdontin B | https://pubchem.ncbi.nlm.nih.gov/compound/101629132 | |
| 12 | Aloesin | https://pubchem.ncbi.nlm.nih.gov/compound/160190 | |
| 13 | Aloenin B (Aloe barbadensis ) | https://pubchem.ncbi.nlm.nih.gov/compound/6442939 |
| # | PHARMACOLOGICAL ACTIONS/THERAPEUTIC USES | REFERENCES |
|---|---|---|
| 1 | Wound Healing | Mendonça FA, Junior JRP, Esquisatto MAM, Mendonça JS, Franchini CC, Santos GMT. Effects of the application of Aloe vera (L.) and microcurrent on the healing of wounds surgically induced in Wistar rats. Acta Cir. Bras.2009; 24:150. Winters WD, Benavides R, Clouse WJ. Effects of Aloe vera extracts on human normal Morton JF. Folk uses and commercial exploitation of aloe leaf pulp. Econ. Bot. 1961; 15:311–319. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol. Cell. Biochem. 1998; 181:71–76. Davis RH, DiDonato JJ, Hartman GM, Haas RC. Antiinflammatory and wound healing activity of a growth substance in Aloe vera. J. Am. Podiatr. Med. Assoc. 1994; 84:77–81. Davis RH, Kabbani JM, Maro NP. Wound healing and anti-inflammatory activity of Aloe vera. Proc. Pa. Acad.Sci. 1986b; 60:79. Heggers JP, Robson MC. Eicosanoids in wound healing. In: Watkins WD, Fletcher JR, Stubbs DF, editors. Prostaglandins in clinical practice. New York: RavenPress; 1989.Fulton JE. The stimulation of post-dermabrasion wound healing with stabilized Aloe vera gel-polyethylene oxide dressing. J. Dermatol. Surg. Oncol. 1990; 16: 460–7. Subramanian S, Satish DK, Arulselvan P. Wound healing potential of Aloe vera leaf gel studied in experimental rabbits. Asian J. Biochem. 2006; 1:178–85.Roberts DB, Travis EL. Acemannan-containing wound dressing gels reduce radiation-induced skin reactions in C3H mice. Int. J. Rad. Oncol. Biol. Physiol. 1995;15:1047–1052. Rajput SS, Soni KK, Saxena RC. Pharmacology and phytochemistry of saponin isolated from Aloe vera for wound healing activity. Asian J. Chem. 2009; 21: 1029–1032.Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol. Cell. Biochem. 1998; 181:71–76. Udupa SL, Udupa AL, Kulkarni DR. Anti-inflammatory and wound healing properties of Aloe vera. Fitoterapia. 1994; 65: 141–145.Davis RH, Leitner MG, Russo J. Aloe vera - a natural approach for treating wounds, edema, and pain in diabetes. J. Am. Podiatr. Med. Assoc. 1988; 78:60–68.Heggers JP, Pelley RP, Robson MC. Beneficial effects of Aloe in wound healing. Phytother. Res. 1993; S48–S52. |
| 2 | Ulcer healing | WRIGHT CS. ALOE VERA IN THE TREATMENT OF ROENTGEN ULCERS AND TELANGIECTASIS. JAMA. 1936;106(16):1363–1364. doi:10.1001/jama.1936.02770160021006 Choonhakarn, C., Busaracome, P., Sripanidkulchai, B. and Sarakarn, P. (2008), The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. British Journal of Dermatology, 158: 573-577. doi:10.1111/j.1365-2133.2007.08370.x Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D. Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J Gastroenterol. 2006;12(13):2034–2039. doi:10.3748/wjg.v12.i13.2034 Bush, J., van den Boom, R. and Franklin, S. (2018), Comparison of aloe vera and omeprazole in the treatment of equine gastric ulcer syndrome. Equine Vet J, 50: 34-40. doi:10.1111/evj.12706 Park, C., Nam, D., Son, H., Lee, S., Lee, H., Heo, J. ... Lee, S. (2011). Polymer fraction of Aloe vera exhibits a protective activity on ethanol-induced gastric lesions. International Journal of Molecular Medicine, 27, 511-518. https://doi.org/10.3892/ijmm.2011.609 LOVEMAN AB. LEAF OF ALOE VERA IN TREATMENT OF ROENTGEN RAY ULCERS: REPORT OF TWO ADDITIONAL CASES. Arch Derm Syphilol. 1937;36(4):838–843. doi:10.1001/archderm.1937.01480040155012 Goutam Brahmachari. 2019. Aloe vera: a promising hope against Buruli ulcer. Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases, pages 373-383. Pankaj K. Sahu, Deen Dayal Giri, Ritu Singh, Priyanka Pandey, Sharmistha Gupta, Atul Kumar Shrivastava, Ajay Kumar, Kapil Dev Pandey. (2013) Therapeutic and Medicinal Uses of Aloe vera: A Review. Pharmacology & Pharmacy 04:08, pages 599-610. |
| 3 | Breastfeeding issues/Breast fissure | Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Aloe. [Updated 2018 Dec 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501829/ Saeidi R, Tafazoli M, Gholami M et al. New treatment for nipple soreness in breastfeeding mothers: A clinical trial study. Iran J Neonatol. 2015;6:48-51. http://ijn.mums.ac.ir/issue_626_671_Volume+6 %2C+Issue+2%2C+Spring+2015.html. Eshgizade M , Moghaddam MB, Moghaddam HM et al. A comparison of the efficacy of olive oil, aloe vera extract and breast milk on healing breast fissure in the breastfeeding women. Avicenna J Phytomedicine. 2015;5:86-7. Meng S, Deng Q, Feng C et al. Effects of massage treatment combined with topical cactus and aloe on puerperal milk stasis. Breast Dis. 2015;35:173-8. Yarnell E. Botanical medicine in pregnancy and lactation. Altern Complement Ther. 1997;3 (April):93-100. Barankin B, Gross MS. Nipple and areolar eczema in the breastfeeding woman. J Cutan Med Surg. 2004;8:126-30. De Smet PA. Health risks of herbal remedies: an update. Clin Pharmacol Ther. 2004;76:1-17. Kopec K. Herbal medications and breastfeeding. J Hum Lact. 1999;15:157-61. Nice F, Coghlan RJ, Birmingham BT. Which herbals are safe to take while breastfeeding? Here's a guide to popular herbs and their potential risk to nurslings. US Pharm. 2000;25 |
| 4 | Dermatitis | Muntingh, George & Finberg, Marike. (2014). A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice. 10.13140/2.1.2750.2083. Da Vardy, Ad Cohen, T Tchetov, E Medvedovsky & A Biton (1999) A double-blind, placebo-controlled trial of an Aloe vera (A. barbadensis) emulsion in the treatment of seborrheic dermatitis, Journal of Dermatological Treatment, 10:1, 7-11, DOI: 10.3109/09546639909055904 Jinkyung Kim, In seok Lee, Soojin Park, Ryowon Choue,Effects of Scutellariae radix and Aloe vera gel extracts on immunoglobulin E and cytokine levels in atopic dermatitis NC/Nga mice,Journal of Ethnopharmacology,Volume 132, Issue 2,2010, Pages 529-532,ISSN 0378-8741,https://doi.org/10.1016/j.jep.2010.08.049. Hogan DJ. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 1988;138(4):336–338. Reuter, J., Wölfle, U., Weckesser, S. and Schempp, C. (2010), Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 8: 788-796. doi:10.1111/j.1610-0387.2010.07496. LOVEMAN AB. LEAF OF ALOE VERA IN TREATMENT OF ROENTGEN RAY ULCERS: REPORT OF TWO ADDITIONAL CASES. Arch Derm Syphilol. 1937;36(4):838–843. doi:10.1001/archderm.1937.01480040155012 Luis J. Borda, Marina Perper & Jonette E. Keri (2019) Treatment of seborrheic dermatitis: a comprehensive review, Journal of Dermatological Treatment, 30:2, 158-169, DOI: 10.1080/09546634.2018.1473554 |
| 5 | Radiation Induced Dermatitis | Ahmadloo N, Kadkhodaei B, Omidvari Sh, Mosalaei A, Ansari M, Nasrollahi H, Hamedi SH, Mohammadianpanah M.Lack of Prophylactic Effects of Aloe Vera Gel on Radiation Induced Dermatitis in Breast Cancer Patients,Asian Pac J Cancer Prev. 2017 Apr 1;18(4):1139-1143. Rao S, Hegde SK, Baliga-Rao MP, Palatty PL, George T, Baliga MS.An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study.Medicines (Basel). 2017 Jun 24;4(3). pii: E44. doi: 10.3390/medicines4030044. Ferreira EB, Vasques CI, Gadia R, Chan RJ, Guerra EN, Mezzomo LA, De Luca Canto G, Dos Reis PE.Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review.Support Care Cancer. 2017 Mar;25(3):1001-1011. doi: 10.1007/s00520-016-3521-7. Haddad P, Amouzgar-Hashemi F, Samsami S, Chinichian S, Oghabian MA. Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial. Curr Oncol. 2013;20(4):e345–e348. doi:10.3747/co.20.1356 Di Franco R, Sammarco E, Calvanese MG, De Natale F, Falivene S, Di Lecce A, Giugliano FM, Murino P, Manzo R, Cappabianca S, Muto P, Ravo V. Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams.Radiat Oncol. 2013 Mar 12;8:57. doi: 10.1186/1748-717X-8-57. Donna Hoopfer, Caroline Holloway, Zsolt Gabos, Maha Alidrisi, Susan Chafe, Barbara Krause, Alan Lees, Nirmal Mehta, Keith Tankel, Faith Strickland, John Hanson, Charlotte King, Sunita Ghosh, Diane Severin,Three-Arm Randomized Phase III Trial: Quality Aloe and Placebo Cream Versus Powder as Skin Treatment During Breast Cancer Radiation Therapy,Clinical Breast Cancer,Volume 15, Issue 3,2015,Pages 181-190.e4,ISSN 1526-8209,https://doi.org/10.1016/j.clbc.2014.12.006. Christina Aquino-Parsons, Sheri Lomas, Keri Smith, Jennifer Hayes, Stephanie Lew, Andrew T. Bates, Alan G. Macdonald,Phase III Study of Silver Leaf Nylon Dressing vs Standard Care for Reduction of Inframammary Moist Desquamation in Patients Undergoing Adjuvant Whole Breast Radiation Therapy,Journal of Medical Imaging and Radiation Sciences,Volume 41, Issue 4,2010,Pages 215-221,ISSN 1939-8654, https://doi.org/10.1016/j.jmir.2010.08.005. |
| 6 | Anti-arthritic | Alan Menter, Neil J. Korman, Craig A. Elmets, Steven R. Feldman, Joel M. Gelfand, Kenneth B. Gordon, Alice Gottlieb, John Y.M. Koo, Mark Lebwohl, Henry W. Lim, Abby S. Van Voorhees, Karl R. Beutner, Reva Bhushan, Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 3. Guidelines of care for the management and treatment of psoriasis with topical therapies,Journal of the American Academy of Dermatology,Volume 60, Issue 4,2009, Pages 643-659,ISSN 0190-9622,https://doi.org/10.1016/j.jaad.2008.12.032. Paul Subhashis,Dutta Tanmoy,Chaudhuri Tapas Kumar,Bhattacharjee Soumen ,Curative and protective properties of crude gel of Aloe vera from sub-Himalayan West Bengal in chronic and acute inflammatory rat models,Indian Journal of Traditional KnowledgeVol. 16(1), January 2017, pp. 121-127 DAVIS, ROBERT H., et al. “ALOE VERA AND INFLAMMATION.” Proceedings of the Pennsylvania Academy of Science, vol. 60, no. 1, 1986, pp. 67–70. JSTOR, www.jstor.org/stable/44111605. Accessed 19 Mar. 2020. Herman CJ, Allen P, Hunt WC, Prasad A, Brady TJ. Use of complementary therapies among primary care clinic patients with arthritis. Prev Chronic Dis. 2004;1(4):A12. Guha P, Subhashis P, Das A, Halder B, Bhattacharjee S, et al. (2014) Analyses of Human and Rat Clinical Parameters in Rheumatoid Arthritis Raise the Possibility of Use of Crude Aloe vera Gel in Disease Amelioration. Immunome Res 10: 081. doi:10.4172/17457580.1000081 |
| 7 | Antidiabetic | Prasannaraja C, Kamalanathan AS, Vijayalakshmi MA, Venkataraman K.A dipyrrole derivative from Aloe vera inhibits an anti-diabetic drug target Dipeptidyl Peptidase (DPP)-IV in vitro.Prep Biochem Biotechnol. 2020 Jan 8:1-10. doi: 10.1080/10826068.2019.1710712 Ghorbani A, Zarvandi M, Rakhshandeh H.A Randomized Controlled Trial of a Herbal Compound for Improving Metabolic Parameters in Diabetic Patients with Uncontrolled Dyslipidemia.Endocr Metab Immune Disord Drug Targets. 2019;19(7):1075-1082. doi: 10.2174/1871530319666190206213420 Noor A, Gunasekaran S, Vijayalakshmi MA. Improvement of Insulin Secretion and Pancreatic β-cell Function in Streptozotocin-induced Diabetic Rats Treated with Aloe vera Extract. Pharmacognosy Res. 2017;9(Suppl 1):S99–S104. doi:10.4103/pr.pr_75_17 Rajasekaran S, Sivagnanam K, Subramanian S. Antioxidant effect of Aloe vera gel extract in streptozotocin‐induced diabetes in rats. Pharmacol Rep, 2005; 57: 90– 96. Rajasekaran S, Sivagnanam K, Subramanian S. Mineral contents of Aloe vera leaf gel and their role on streptozotocin‐induced diabetic rats. Biol Trace Elem Res, 2005; 108: 185– 195. Misawa E, Tanaka M, Nomaguchi K, Yamada M, Toida T, Takase M, Iwatsuki K, Kawada T. Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats. Obes Res Clin Prac, 2008; 2: 239– 245. Kim K, Kim H, Kwon J et al. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non‐insulin‐dependent diabetes mellitus. Phytomedicine, 2009; 16: 856– 863. Kong H, Lee S, Shin S et al. Down‐regulation of adipogenesis and hyperglycemia in diet‐induced obesity mouse model by Aloe QDM. Biomol Ther, 2010; 18: 336– 342. Shin E, Shim KS, Kong H et al. Dietary aloe improves insulin sensitivity via the suppression of obesity‐induced inflammation in obese mice. Immune Netw, 2011; 11: 59– 67. Misawa E, Tanaka M, Nomaguchi K, Nabeshima K, Yamada M, Toida T, Iwatsuki K. Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity‐associated metabolic disorders in zucker diabetic fatty rats. J Agric Food Chem, 2012; 60: 2799– 2806. Akpan UP, Nna VU, Ofem OE, Antai AB, Osim EE. Suppression of gut glucose absorption and enhancement of gut fluid absorption in Alloxan ‐ induced diabetic rats treated with crude Aloe vera gel. Res J Pharm, Biol Chem Sci, 2014; 5: 647– 655. Ghannam N, Kingston M, Al‐Meshaal IA, Tariq M, Parman NS, Woodhouse N. The antidiabetic activity of aloes: preliminary clinical and experimental observations. Horm Res, 1986; 24: 288– 294. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine, 1996; 3: 245– 248. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine, 1996; 3: 241– 243. Yagi A, Hegazy S, Kabbash A, Wahab EA. Possible hypoglycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients. Saudi Pharm J, 2009; 17: 209– 215 Choudhary M, Kochhar A, Sangha J. Hypoglycemic and hypolipidemic effect of Aloe vera L. in non‐insulin dependent diabetics. J Food Sci Technol, 2014; 51: 90– 96. Alinejad‐Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. Improvement of glucose and lipid profile status with Aloe vera in pre‐diabetic subjects: a randomized controlled‐trial. J Diabet Metab Disord, 2015; 14: 1– 7. Arora D, Goyal M, Agarwal RP. Efficacy of Aloe vera juice consumption on glycemic response in type‐2 diabetic patients. J Food Sci Technol, 2009; 46: 160– 162. Huseini HF, Kianbakht S, Hajiaghaee R, Afkhami‐Ardekani M, Bonakdaran A, Dabaghian FH. Aloe vera leaf gel in treatment of advanced type 2 diabetes mellitus needing insulin therapy: a randomized double‐blind placebo‐controlled clinical trial. J Med Plants, 2012; 11: 19– 27. Ngo MQ, Nguyen NN, Shah SA. Oral Aloe vera for treatment of diabetes mellitus and dyslipidemia. Am J Health‐Syst Pharm, 2010; 67: 1804– 1811. |
| 8 | FILARIASIS | Maurya P, Mohan L, Sharma P, Srivastava CN.Larval susceptibility of Aloe barbadensis and Cannabis sativa against Culex quinquefasciatus, the filariasis vector.J Environ Biol. 2008 Nov;29(6):941-3. |
| 9 | Vitamin deficiency(B12) | Jung-Mi Yun, Sital Singh, Rohan Jialal, Jason Rockwood, Ishwarlal Jialal & Sridevi Devaraj (2010) A Randomized Placebo-Controlled Crossover trial of Aloe Vera on Bioavailability of Vitamins C and B12, Blood Glucose, and Lipid Profile in Healthy Human Subjects, Journal of Dietary Supplements, 7:2, 145-153, DOI: 10.3109/19390211003781693 Jian Jiao, Na Meng, Hong Wang, Luo Zhang. (2013) The effects of vitamins C and B12 on human nasal ciliary beat frequency. BMC Complementary and Alternative Medicine 13:1. Elena Rodríguez Rodríguez, Jacinto Darias Martín & Carlos Díaz Romero (2010) Aloe vera as a Functional Ingredient in Foods, Critical Reviews in Food Science and Nutrition, 50:4, 305-326, DOI: 10.1080/10408390802544454 |
| 10 | Immunostimulatory activity | Nirmal Pugh,Samir A. Ross, Mahmoud A. ElSohlyand, and David S. Pasco,Journal of Agricultural and Food Chemistry 2001 49 (2), 1030-1034 DOI: 10.1021/jf001036d Sun-A Im, Sun-Tack Oh, Sukgil Song, Mi-Ran Kim, Dong-Seon Kim, Sung-Sick Woo, Tae Hyung Jo, Young In Park, Chong-Kil Lee,Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity, International Immunopharmacology,Volume 5, Issue 2,2005,Pages 271-279,ISSN 1567-5769,https://doi.org/10.1016/j.intimp.2004.09.031. Im, S., Lee, Y., Lee, Y. et al. In vivo evidence of the immunomodulatory activity of orally administered Aloe vera gel. Arch. Pharm. Res. 33, 451–456 (2010). https://doi.org/10.1007/s12272-010-0315-1 Qiu, Z., Jones, K., Wylie, M., Jia, Q., and Orndorff, S., Modified Aloe barbadensis polysaccharide with immunoregulatory activity. Planta Med., 66, 152–156 (2000) Lee, J. K., Lee, M. K., Yun, Y.-P., Kim, Y., Kim, J. S., Kim, Y. S., Kim, K., Han, S. S., and Lee, C. K., Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. Int. Immunopharmacol., 1, 1275–1284 (2001). |
| 11 | Anti-tumor activity | Winters, W.D., Benavides, R. & Clouse, W.J. Effects of aloe extracts on human normal and tumor cells in vitro. Econ Bot 35, 89–95 1981) https://doi.org/10.1007/BF02859219 Chaudhary, G., Ram, M., & Kumar, P. (2007). Chemopreventive Potential of Aloe vera Against 7,12-Dimethylbenz(a)anthracene— Induced Skin Papillomagenesis in Mice. Integrative Cancer Therapies, 405–412. https://doi.org/10.1177/1534735407309079 Kocik J, Bałan BJ, Zdanowski R, Jung L, Skopińska-Różewska E, Skopiński P. Feeding mice with Aloe vera gel diminishes L-1 sarcoma-induced early neovascular response and tumor growth. Cent Eur J Immunol. 2014;39(1):14–18. doi:10.5114/ceji.2014.42116 Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of Aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther. 2004;19:521–527. Akev N, Turkay G, Can A, et al. Tumor preventive effect of Aloe vera leaf pulp lectin (Aloctin I) on Ehrlich ascites tumours in mice. Phytother Res. 2007;21:1070–1075. Rebeka Tomasin, Rafael Siqueira de Andrade, and Maria Cristina Cintra Gomes-Marcondes Oral Administration of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and Honey Improves the Host Body Composition and Modulates Proteolysis Through Reduction of Tumor Progression and Oxidative Stress in Rats Pandiri, A. R., Sills, R. C., Hoenerhoff, M. J., Peddada, S. D., Ton, T.-V. T., Hong, H.-H. L., … Boudreau, M. D. (2011). Aloe vera Non-Decolorized Whole Leaf Extract-Induced Large Intestinal Tumors in F344 Rats Share Similar Molecular Pathways with Human Sporadic Colorectal Tumors. Toxicologic Pathology, 39(7), 1065–1074. https://doi.org/10.1177/0192623311422081 |
| 12 | Antimicrobial | Arunkumar, Subbian, and M. Muthuselvam. “Analysis of phytochemical constituents and antimicrobial activities of Aloe vera L. against clinical pathogens.” (2009). D. Jasso de Rodrı́guez, D. Hernández-Castillo, R. Rodrı́guez-Garcı́a, J.L. Angulo-Sánchez, Antifungal activity in vitro of Aloe vera pulp and liquid fraction against plant pathogenic fungi, Industrial Crops, and Products, Volume 21, Issue 1,2005, Pages 81-87, ISSN 0926-6690,https://doi.org/10.1016/j.indcrop.2004.01.002. Tonea A, Badea M, Oana L, Sava S, Vodnar D. Antibacterial and antifungal activity of endodontic intracanal medications. Clujul Med. 2017;90(3):344–347. doi:10.15386/cjmed-750 Yolanta Saks, Rivka Barkai-Golan, Aloe vera gel activity against plant pathogenic fungi, Postharvest Biology and Technology, Volume 6, Issues 1–2,1995, Pages 159-165, ISSN 0925-5214,https://doi.org/10.1016/0925-5214(94)00051-S. J.A. Zygadlo, N.R. Grosso, Comparative study of the antifungal activity of essential oils from aromatic plants growing wild in the central region of Argentina Flavour Fragrance J, 10 (1995), pp. 113-118 K. Fujita, Y. Yamada, K. Azuma, S. Hirozawa, Effect of leaf extracts of Aloe arborescens Miller spp. natalensis Berger, active against the human fungal pathogen Trichophyton mentagrophytes Antimicrob. Agents Chemother, 14 (1978), pp. 132-136H Levin, R. Hazenfratz, J. Friedman, D. Palevitch, M. Perl, Partial purification and some properties of an antibacterial compound from Aloe vera Phytother. Res, 2 (1988), pp. 67-69 |
| 13 | Burn Healing | Ratree Maenthaisong, Nathorn Chaiyakunapruk, Surachet Niruntraporn, Chuenjid Kongkaew,The efficacy of aloe vera used for burn wound healing: A systematic review,Burns,Volume 33, Issue 6,2007,Pages 713-718,ISSN 0305-4179, https://doi.org/10.1016/j.burns.2006.10.384. Itxaso Garcia-Orue, Garazi Gainza, Franciso Borja Gutierrez, Jose Javier Aguirre, Carmen Evora, Jose Luis Pedraz, Rosa Maria Hernandez, Araceli Delgado, Manoli Igartua,Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications,International Journal of Pharmaceutics,Volume 523, Issue 2, 2017,Pages 556-566,ISSN 0378-5173,https://doi.org/10.1016/j.ijpharm.2016.11.006. Somboonwong J, Thanamittramanee S, Jariyapongskul A, Patumraj S. Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. J Med Assoc Thai. 2000 Apr;83(4) 417-425. PMID: 10808702. Theodor Kaufman, MD, Noam Kalderon, MD, Yehuda Ullmann, MD, Joseph Berger, MD, Aloe Vera Gel Hindered Wound Healing of Experimental Second-Degree Burns: A Quantitative Controlled Study, The Journal of Burn Care & Rehabilitation, Volume 9, Issue 2, March-April 1988, Pages 156–159, https://doi.org/10.1097/00004630-198803000-00005 |
| 14 | Dentistry | Mangaiyarkarasi SP, Manigandan T, Elumalai M, Cholan PK, Kaur RP. Benefits of Aloe vera in dentistry. J Pharm Bioallied Sci. 2015;7(Suppl 1):S255–S259. doi:10.4103/0975-7406.155943 Tayal, E., Sardana, D., R. InduShekar, K., G. Saraf, B., & Sheoran, N. (2014). Current Perspectives on Use of Aloe vera in Dentistry. European Journal of Medicinal Plants, 4(12), 1408-1419. https://doi.org/10.9734/EJMP/2014/10843 Neena IE, Ganesh E, Poornima P, Korishettar R. An ancient herb aloe vera in dentistry: A review. J Oral Res Rev 2015;7:25-30 Bhat G, Kudva P, Dodwad V. Aloe vera: Nature's soothing healer to periodontal disease. J Indian Soc Periodontol. 2011;15(3):205–209. doi:10.4103/0972-124X.85661 Langmead, L., Feakins, R.M., Goldthorpe, S., Holt, H., Tsironi, E., De Silva, A., Jewell, D.P. and Rampton, D.S. (2004), Randomized, double‐blind, placebo‐controlled trial of oral aloe vera gel for active ulcerative colitis. Alimentary Pharmacology & Therapeutics, 19: 739-747. doi:10.1111/j.1365-2036.2004.01902.x |
| 15 | Cholestrol Lowering | Manoj Kumar, Shruti Rakesh, Ravinder Nagpal, R. Hemalatha, A. Ramakrishna, V. Sudarshan, Ramesh Ramagoni, Mohd Shujauddin, Vinod Verma, Ashok Kumar, Akhilesh Tiwari, Birbal Singh, Rajesh Kumar,Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats, Nutrition,Volume 29, Issue 3,2013,Pages 574-579,ISSN 0899-9007, https://doi.org/10.1016/j.nut.2012.09.006. Dana N, Javanmard SH, Asgary S, Asnaashari H, Abdian N. The effect of Aloe vera leaf gel on fatty streak formation in hypercholesterolemic rabbits. J Res Med Sci. 2012;17(5):439–442. Geremias, R., Pedrosa, R.C., Locatelli, C., de Fávere, V.T., Coury‐Pedrosa, R. and Laranjeira, M.C.M. (2006), Lipid lowering activity of hydrosoluble chitosan and association with Aloe vera L. and Brassica olearaceae L.. Phytother. Res., 20: 288-293. doi:10.1002/ptr.1854 Nour W. Al-Haj Baddar, Talal A. Aburjai, Mutasem O. Taha & Ahmad M. Disi (2011) Thujone corrects cholesterol and triglyceride profiles in diabetic rat model, Natural Product Research, 25:12, 1180-1184, DOI: 10.1080/14786419.2010.496116 Desai BN, Maharjan RH, Nampoothiri LP. Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model. Pharmacognosy Res. 2012;4(2):109–115. doi:10.4103/0974-8490.94736 |
| 16 | Tendinitis | A.A. Aro, U. Nishan, M.O. Perez, R.A. Rodrigues, M.A. Foglio, J.E. Carvalho, L. Gomes, B.C. Vidal, E.R. Pimentel, Structural and biochemical alterations during the healing process of tendons treated with Aloe vera, Life Sciences, Volume 91, Issues 17–18,2012, Pages 885-893, ISSN 0024-3205,https://doi.org/10.1016/j.lfs.2012.09.002. Ammendolia, A., Cespites, M. & Iocco, M. Topical use of aloe gel and low-level laser therapy in overuse tendinitis of elite volleyball players: a randomized controlled trial. Sport Sci Health 12, 209–213 (2016). https://doi.org/10.1007/s11332-016-0276-y Moura Júnior, M.J., Arisawa, E.Â.L., Martin, A.A. et al. Effects of low-power LED and therapeutic ultrasound in the tissue healing and inflammation in a tendinitis experimental model in rats. Lasers Med Sci 29, 301–311 (2014). https://doi.org/10.1007/s10103-013-1327-0 Casalechi, H.L., Leal-Junior, E.C.P., Xavier, M. et al. Low-level laser therapy in an experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases. Lasers Med Sci 28, 989–995 (2013). https://doi.org/10.1007/s10103-012-1189-x Antonio Luiz Martins Maia Filho, Antonio Balbin Villaverde, Egberto Munin, Flávio Aimbire, Regiane Albertini, Comparative Study of the Topical Application of Aloe Vera Gel, Therapeutic Ultrasound and Phonophoresis on the Tissue Repair in Collagenase-Induced Rat Tendinitis, Ultrasound in Medicine & Biology, Volume 36, Issue 10,2010, Pages 1682-1690, ISSN 0301-5629,https://doi.org/10.1016/j.ultrasmedbio.2010.06.012. |
| 17 | Psoriasis | Syed, T.A., Ahmad, S.A., Holt, A.H., Ahmad, S.A., Ahmad, S.H. and Afzal, M. (1996), Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo‐controlled, double‐blind study*. Tropical Medicine & International Health, 1: 505-509. doi:10.1046/j.1365-3156.1996.d01-91.x Paulsen, E., Korsholm, L. and Brandrup, F. (2005), A double‐blind, placebo‐controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. Journal of the European Academy of Dermatology and Venereology, 19: 326-331. doi:10.1111/j.1468-3083.2004.01186.x Choonhakarn, C., Busaracome, P., Sripanidkulchai, B. and Sarakarn, P. (2010), A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. Journal of the European Academy of Dermatology and Venereology, 24: 168-172. doi:10.1111/j.1468-3083.2009.03377.x Dhanabal, S.P., Priyanka Dwarampudi, L., Muruganantham, N. and Vadivelan, R. (2012), Evaluation of the Antipsoriatic Activity of Aloe Vera Leaf Extract Using a Mouse Tail Model of Psoriasis. Phytother. Res., 26: 617-619. doi:10.1002/ptr.3589 Farahnik, B., Sharma, D., Alban, J. et al. Topical Botanical Agents for the Treatment of Psoriasis: A Systematic Review. Am J Clin Dermatol 18, 451–468 (2017). https://doi.org/10.1007/s40257-017-0266-0 Maha A. El-Gayyar, Amany A. El-Hawwary and Nagwa I. Bakre, 2012. Evaluation of Therapeutic Effects of Aloe Vera: Coal Tar Mixture in Psoriasis: An Immunohistochemical Study. Asian Journal of Dermatology, 4: 16-28. |
| 18 | Skin Cancer | Son Won Byeon, Ronald P. Pelley, Stephen E. Ullrich, Todd A. Waller, Corazon D. Bucana, Faith M. Strickland, Aloe Barbadensis Extracts Reduce the Production of Interleukin-10 After Exposure to Ultraviolet Radiation, Journal of Investigative Dermatology, Volume 110, Issue 5,1998, Pages 811-817, ISSN 0022-202X, https://doi.org/10.1046/j.1523-1747.1998.00181.x. Honnavara N. Ananthaswamy, Susan M. Loughlin, Stephen E. Ullrich, Margaret L. Kripke, Inhibition of UV-Induced p53 Mutations by Sunscreens: Implications for Skin Cancer Prevention, Journal of Investigative Dermatology Symposium Proceedings, Volume 3, Issue 1,1998, Pages 52-56, ISSN 1087-0024,https://doi.org/10.1038/jidsymp.1998.13. Faith M Strickland, Immune regulation by polysaccharides: implications for skin cancer, Journal of Photochemistry and Photobiology B: Biology, Volume 63, Issues 1–3, 2001,Pag es 132-140,ISS N 1011-1344,https://doi.org/10.1016/S1011-1344(01)00210-X. |
| 19 | Constipation | Madar Z. A double-blind trial of a celandin, Aloe vera and psyllium laxative preparation in adult patients with constipation. Digestion. 1991; 49:65–71. |
| 20 | Anti-inflammatory | Esua MF, Rauwald JW. Novel bioactive maloyl glucans from Aloe vera gel: isolation, structure elucidation and in vitro bioassays. Carbohydr. Res. 2006; 341:355–364. Park MY, Kwon HJ, Sung MK. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Biosci. Biotechnol. Biochem. 2009; 73: 828–832. Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT et al. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J. Nat. Prod. 1996; 59:541–543. Udupa SL, Udupa AL, Kulkarni DR. Anti inflammatory and wound healing properties of Aloe vera. Fitoterapia. 1994; 65: 141–145. Vázquez B, Avila G, Segura D, Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. J. Ethnopharmacol. 1996; 55: 69–75. Davis RH, Leitner MG, Russo J. Topical anti inflammatory activity of Aloe vera as measured by ear swelling. J. Am. Podiatr. Med. Assoc. 1987; 77:610–612. |
| 21 | Other Activities | ACUTE MYELOID LEUKEMIA, ADENOCARCINOMA, ALLERGIC RHINITIS, ASTHMA, CERVIX CARCINOMA, FIBROMYALGIA, HEPATOMA, HIGH BLOOD PRESSURE, HYPERSENSITIVITY, HYPERTHYROIDISM, HYPOTHYROIDISM |
| # | AVALAIBLE PRODUCTS | MANUFACTURERS AND SUPPLIERS | URL |
|---|---|---|---|
| 1 | ALOEVERA JUICE WITH FIBER (L) 1000 ml | Patanjali Ayurvedic limited | Open Url |
| 2 | Aloe Vera Juice500ml | Be sure | Open Url |
| 3 | Lily Of The Desert Aloe Vera Gel Whole Leaf | Lily Of The Desert | Open Url |
| 4 | George's Aloe Vera Liquid Supplement | George's | Open Url |
| 5 | Nutriherbs Aloe Vera Extract | NUTRIHERBS | Open Url |
| 6 | Forever Aloe Vera Gel Minis | Forever | Open Url |
| 7 | GNC Aloe Vera Gel | GNC | Open Url |
| 8 | Imc Herbal Aloevera Juice | NAVYUG IMC HERBAL INDIA | Open Url |
| # | AYURVEDIC FORMULATIONS (TKDL) | UNANI FORMULATIONS (TKDL) | SIDDHA FORMULATIONS (TKDL) |
|---|---|---|---|
| 1 | Kanyasvara | Dawa-e- Ahmar | Kaantha Chendooram-2 |
| 2 | Jvarevamanam | Anzaroot | Vanga Chenduram |
| 3 | Lohamarnam(05) | Afratiqoon | Sathi Gunma Kudineer |
| 4 | Lohamarnam(12) | Hab Tehaal | Maantha Sura Kudineer |
| 5 | Jvararirasa(04) | Hanzal | Suyamagini Mathirai |
| 6 | Lohamarnam(10) | Elwa | Mandoora Centuram |
| 7 | Lohamarnam(11) | Halwa Sibr | Aan Kudhirai Enbu Parpam |
| 8 | Lohanirutthikararnam | Iyaarij -e- Faiqara | Mandoora Chenduram |
| 9 | Jvaraghanigutika | Marham -e- Aswad | Thiriloga Centuram |
| 10 | "Bhargyadigutika " | Iyaarij-e-sard | Abraha Parpam |
| 11 | Iyaarij-e-shabyaar | ||
| 12 | Iyaarij -e- Loghazia Ba Nuskha-e- Yunus | ||
| 13 | Dahmarsa | ||
| 14 | Majoon-e- Balaadur |
Global End Use Market
Food, cosmetics, pharmaceuticals
Available Global Market
China, India, South Africa, South korea, Germany, France, US, Canada, Mexico, North America, Western Europe, Hong- Kong, Japan, Malaysia, Singapore, USA
Global Manufacturer Extract
Desert Organic Aloeceuticals, Aloe Farms Inc., Terry Laboratories Inc., Foodchem International Corporation, Natural Aloe Costa Rica S.A., Pharmachem Laboratories Inc., Aloecorp Inc., Aloe Laboratories Inc., Pokonobe Inc., Lily of the Desert Organic Aloeceuticals, Foodchem International Corporation, Aloe Farms Inc., Natural Aloe Costa Rica S.A., Aloecorp Inc., Cady products LLC, Pharmachem Laboratories Inc.,Forever Living, Natural Republic, Marykay, Shiseido, Watsons, GNC, P and G, Unilever, L'Oreal, LVMH, Patanjali Ayurved Pechoin Base Formula Ltd
Distribution in IORA Countries
Yemen, Bangladesh, India, Mauritius, Sri -Lanka,Thailand, Madagascar, Comoros, Mozambique, Seychelles, Somalia, Kenya, South Africa,Tanzania
Source Supply
Tropical and subtropicals
Trade Name
KATTAARVAZHAPPOLA PACHA, LOLISARA, KATTAARVAZHAPPOLA, KUWARPATHA, KUMARI, ALIYO, ALOE-VERA
Annual Consumption (in MT)
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| # | ADDRESSES OF MEDICINAL PLANTS TRADERS |
|---|---|
| 1 | Chum Impex Private LimitedLSC Site 37/38, Bh Property No. 14, PO Kalkaji, Delhi-110019, India |
| 2 | B & B Agro India EnterprisesPlot No. 22, Mahavir Enclave, R Z-D-1/94, Street No. 5, Near Sulabh International, Palam Village Southwest, New Delhi-110045, Delhi, India |
| 3 | Shekhawati Agro ProductsRajpura, Khod, Losal-332025, Rajasthan, India |
| 4 | Matrukrupa FarmSavsar Plot, Rajdhani Complex, Near By Old St Bus Stand, Near Morbi Old Bus Stand, Savsar Plot Area, Morbi-363641, Gujarat, India |
| 5 | SV Agro FoodC 403, Ambika Apartments CHS Plot No. A9, Sector 20, Nerul, Navi Mumbai-400706, Maharashtra, India |
| 6 | Ishan Herbotech International Office No. D-10, Epip (export Promotional Industrial Park), Kasna, Greater Noida-201310, Uttar Pradesh, India |
| 7 | Shiv BiotechNew Road, Opposite Railway Station, Opposite Railway Station, New Road, Churu-331001, Rajasthan, India |
| 8 | Gloria Pharma ExportersX/707- C, Kakkanad, Kakkanad, Kochi-682030, Kerala, India |
IC111271, IC111269, IC111280, IC111273, IC111279 and IC111267:-Released by National Botanical and Plant Genetic Resource, ICAR, Delhi. It has high aloin content. IC111267, IC1112666, IC111280, IC111280, IC111272 and IC111277:- Released by National Botanical and Plant Genetic Resource, ICAR, Delhi. It contains high gel contents. AL-1:- Released by Central Institute of Medicinal and Aromatic Plants, Lucknow."
| # | Source (Link) |
|---|---|
| 1 | ---- |