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Nardostachys jatamansi (D.Don) DC.
BOTANICAL DETAILS OF PLANT
Synonyms
Nardostachys chinensis Batalin
Kew Herbarium Links
Classification
Kingdom
Plantae
Subkingdom
-
Superdivision
-
Division
-
Class
Magnoliopsida
Subclass
-
Order
Dipsacales
Family
Valerianaceae
Genus
Nardostachys DC.
Species
Nardostachys jatamansi (D.Don) DC.
Plant Description
Perennials, aromatic, herbaceous, erect rhizomatous herbs. Stems 5-50 cm tall. Stems pubescent upwards, glabrous below. Rhizome long, stout, outer layer covered with reddish-brown, fibrous remains of the petioles of dead leaves. Leaves are simple, opposite, rosette; Radical leaves spatulate or linear-oblanceolate 5-25 × 0.5-2.5 cm, glabrous or slightly pubescent, base attenuate, margin entire, apex obtuse; Cauline leaves elliptic to obovate mostly 1 -3 in pairs. Inflorescence capitula of cymes, 1.5-4 x 0.5-2 cm across, bracts in 3-5 whorls, involucral bracts 4-6, lanceolate; bracts ovate. Flowers many usually 1- 5; Calyx 5-lobed; lobes semiorbicular, pubescent. Corolla purple red, pink, white, campanulate,0.8cm long, 5-lobed. Stamens 4, filaments villous.Ovary 3- celled, ovule-1; stigma capitate. fruit-Achenes obovate, 3-4 mm, with white hairs crowned by calyx-lobes.
Habit/Life Form
Herb
DISTRIBUTION OF SPECIES IN INDIA
Montane and sub-alpine zones of the Himalayas, from Kumaon to Sikkim, Arunachal Pradesh, Jammu & Kashmir, Sikkim, and Uttarakhand.
AGROCLIMATIC CONDITIONS
| # | Soil and Climate | Temperature (°C) | Average Annual Rainfall (mm) |
|---|---|---|---|
| 1 | Soil: Sandy loam and acidic soil. Moist and partial sunny areas are found suitable | 5-15 | 250 |
Local Names
| # | Language Name | Local Name |
|---|---|---|
| 1 | Hindi | balchjari, Bal-chir,jatamasi,mansi, nihani, smak, tagar |
| 2 | Kannada | jatale, naati jatamaansi, nandu batlu, |
| 3 | Marathi | thagar mool |
| 4 | Sanskrit | jatamansi, natah, tagarah |
| 5 | Tamil | shadamangie, takaram |
| 6 | Telugu | tagara |
| 7 | Others | Mamsi, Jata Jatila, Balchara & Sumbul-ut-teeb |
International Local Names
| # | Country Name | Local Name |
|---|---|---|
| 1 | English | True Spikenard,Musk root ,Indian Valerian,Indian Nard,Mountain NardGerman |
| 2 | German | Indische Narde |
| 3 | French | Nard indien |
| 4 | Italian | Spignard |
| 5 | Spanish | Nardo indico |
| 6 | Persian | Sumbul-i-Hindi |
| 7 | Indian | Bhutakesi |
| 8 | Turkish | Hint sumbulu |
| 9 | nepal | Haswa,jatamangsi,Naswa |
| 10 | Chinese | Gan Son |
| 11 | Iran | Hufarighun,Sonboletib |
Plant Parts Used
Rhizome and roots
System of Medicine
Ayurveda, Siddha, Unani systems of India, Tibetan, and Chinese systems of medicine
Intended Use
Epilepsy, hysteria, syncope, convulsions, cerebral ischemia, vertigo, insomnia, hypertension, asthma, liver disorders, hair fall, heart diseases, and mental weakness.
Traditional Application
1- The roots and rhizomes of Nardostachys jatamansi are used to cure various diseases like - hysteria, syncope epilepsy, and mental weakness (Sahu R, Dhongade H. J, Pandey A, Sahu P, Sahu V, Patel D, Kashyap P. Medicinal Properties of Nardostachys jatamansi (A Review). Orient J Chem 2016;32(2).
2- Nardostachys jatamansi root is used by traditional healers against poisonous and non-poisonous bites and stings. (Modak BK, Gorai P, Pandey DK, Dey A, Malik T (2020) An evidence-based efficacy and safety assessment of the ethnobiological against poisonous and non-poisonous bites used by the tribals of three westernmost districts of West Bengal, India: Anti-phospholipase A2 and genotoxic effects. PLoS ONE 15(11): e0242944. https://doi.org/10.1371/journal.pone.0242944).
3- Khongleng, Monpa tribe of West Kameng district and Tawang district in Arunachal Pradesh use root to treat fever, dysentery, cold, influenza, chronic fever, and jaundice. At several places in Arunachal Pradesh herb is practiced as a cardiac tonic. (Umesh kumar L. Tiwari, Amit Kotia, and Gopal Singh Rawat, Medico-ethnobotany of the Monpas in Tawang and West Kameng districts of Arunachal Pradesh, India, Pleione 3(1): 1-8. 2009.
4- Roots and leaves powder is given with warm water to treat internal pain (Khima Nand, Suneet Naithani, Ethnobotanical uses of wild medicinal plants by the local community in the Asi Ganga sub-basin, Western Himalaya,JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH, 2018VOL 9, NO. 1, PAGE 34–4610.5455/jcmr.20180507034822ORIGINAL RESEARCH).
5- Nardostachys jatamansi is effective in learning. Due to its high medicinal properties, it is considered as a memory enhancer. (Michael Adams, Francine Gmünder, Matthias Hamburger, Plants traditionally used in age-related brain disorders—A survey of ethnobotanical literature, Journal of Ethnopharmacology, Volume 113, Issue 3,2007, Pages 363-381, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2007.07.016.)
6- The plant is useful in lithiasis (Kumkum Agarwal, Ranjana Varma, Ethnobotanical study of antilithic plants of Bhopal district, Journal of Ethnopharmacology, Volume 174,2015, Pages 17-24, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2015.08.003.)
7– The Rudraprayag district (Uttarakhand state) local people rely on medicinal plants for their primary healthcare. Nardostachys jatamansi is an important plant species of this region and is practiced well. 2 g root powder with lukewarm water is consumed orally for 2–3 weeks to treat conditions like -high blood pressure and insomnia.(Deepak J Londhe, Jagdish C Arya, Om Prakash, Chinmay Rath, Anupam K Mangal,Folklore Practices of Medicinal Plants by Local Community in Ukhimath Forest Area of Rudraprayag District, Uttarakhand, India: Ethnobotanical Survey,Folklore Practices of Medicinal Plants by Local Community in Ukhimath Forest AreaJournal of Drug Research in Ayurvedic Sciences, Volume 5 Issue 2 (April–June 2020)
8-palpitation of heart, chorea, and flatulence, etc. It is also used with much success in epilepsy and similar nervous and convulsive ailments. It has been also recommended as a diuretic, emmenagogue and in many eases of digestive and respiratory organs. It is also used to undice, and promote the growth and blackness of hair.
Uses in IORA Countries
| # | Country Name | Uses |
|---|---|---|
| 1 | Iran | 1-Residents of Bojnord, North Khorasan Province uses herb for various therapeutic purposes. Root infusion is considered for neuropsychological disorders. (Nadaf M, Joharchi MR, Amiri MS. Ethnomedicinal uses of plants for the treatment of nervous disorders at the herbal markets of Bojnord, North Khorasan Province, Iran.Avicenna J Phytomed, 2018). 2-People of Mashhad province Iran's uses it for migraine.(Nahid Jivad, Majid Asadi-Samani, Mohammad Taghi Moradi,The most important medici |
| 2 | Nepal | In Nepal the plant is useful in lithiasis |
Phytochemical Details
| # | Phytochemical Constituents | PUBCHEM CID | References |
|---|---|---|---|
| 1 | Nardostachysin | 10598736 | Asima Chatterjee, Bidyut Basak, Munmun Saha, Utpal Dutta, Chaitali Mukhopadhyay, Julie Banerji, Yaeko Konda, and Yoshihiro Harigaya Journal of Natural Products 2000 63 (11), 1531-1533 DOI: 10.1021/np990503m Saroya A.S., Singh J. (2018) Neuropharmacology of Nardostachys jatamansi DC.. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_17 |
| 2 | Jatamansone | 10198387 | Gupta PD, Virmani V. Clinical trial of jatamansone (syn: Valeranone) in hyperkinetic behaviour disorders. Neurol India. 1968 Oct-Dec;16(4):168-73. PMID: 4886500. Saroya A.S., Singh J. (2018) Neuropharmacology of Nardostachys jatamansi DC.. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_17 |
| 3 | Spirojatamol | 11053257 | |
| 4 | Jatamols A | 101618011 | Bagchi A, Oshima Y, Hikino H. Jatamols A and B: sesquiterpenoids of Nardostachys jatamansi roots. Planta Med. 1991;57:282–3. |
| 5 | Jatamols B | 6429183 | Saroya A.S., Singh J. (2018) Neuropharmacology of Nardostachys jatamansi DC.. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_17 |
| 6 | Jatamansin | 668081 | BISWAS K. FARMACOLOGIA DEL JATAMANSIN. SUSTANCIA ACTIVA DEL VEGETAL NARDOSTACHYS JATAMANSI [PHARMACOLOGY OF JATAMANSIN. ACTIVE SUBSTANCE OF THE PLANT NARDOSTACHYS JATAMANSI]. Prensa Med Argent. 1963 Apr 19;50:1021-5. Spanish. PMID: 14078287. Saroya A.S., Singh J. (2018) Neuropharmacology of Nardostachys jatamansi DC.. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_17 |
| 7 | Valeranone | 171455 | Rücker G, Tautges J, Sieck A, Wenzl H, Graf E. Untersuchungen zur Isolierung und pharmakodynamischen Aktivität des Sesquiterpens Valeranon aus Nordostachys jatamansi DC [Isolation and pharmacodynamic activity of the sesquiterpene valeranone from Nardostachys jatamansi DC]. Arzneimittelforschung. 1978;28(1):7-13. German. PMID: 580202. |
| 8 | Nardostachone | -- | Saroya A.S., Singh J. (2018) Neuropharmacology of Nardostachys jatamansi DC.. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_17 Gowda, D. K., Shetty, L., A P, K., Kumari, S. N., Sanjeev, G., & P, N. (2013). The efficacy of nardostachys jatamansi against the radiation induced haematological damage in rats. Journal of clinical and diagnostic research : JCDR, 7(6), 982–986. https://doi.org/10.7860/JCDR/2013/5475.3078 |
| 9 | Nardal | -- | Venkateswara Rao, Dr & Annamalai, T. & Mukhopadhyay, Triptikumar. (2008). ChemInform Abstract: Nardal, a New Sesquiterpene Aldehyde from the Plant, Nardostachys jatamansi DC. Cheminform. 39. 10.1002/chin.200817186. Rao, G., Annamalai, T., & Mukhopadhyay, T. (2008). Nardal, a New Sesquiterpene Aldehyde from the Plant, Nardostachys jatamansi DC. ChemInform, 39. Gottumukkala, V. R., Annamalai, T., & Mukhopadhyay, T. (2011). Phytochemical investigation and hair growth studies on the rhizomes of Nardostachys jatamansi DC. Pharmacognosy magazine, 7(26), 146–150. https://doi.org/10.4103/0973-1296.80674 |
| 10 | Jatamansinone | 759294 | -- |
| 11 | Angelcin | -- | Sahu R, Dhongade H. J, Pandey A, Sahu P, Sahu V, Patel D, Kashyap P. Medicinal Properties of Nardostachys jatamansi (A Review). Orient J Chem 2016;32(2) |
| 12 | Jatamansic acid | -- | Gottumukkala, V. R., Annamalai, T., & Mukhopadhyay, T. (2011). Phytochemical investigation and hair growth studies on the rhizomes of Nardostachys jatamansi DC. Pharmacognosy magazine, 7(26), 146–150. https://doi.org/10.4103/0973-1296.80674 Madhu, L. N., Kumari, N. S., Naveen, P., & Sanjeev, G. (2012). Protective Effect of Nardostachys jatamansi Against Radiation-induced Damage at Biochemical and Chromosomal Levels in Swiss Albino Mice. Indian journal of pharmaceutical sciences, 74(5), 460–465. https://doi.org/10.4103/0250-474X.108425 |
| 13 | Jatamansonol | -- | Vidya S. Rao, Anjali Rao, K. Sudhakar Karanth, Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats, Journal of Ethnopharmacology, Volume 102, Issue 3, 2005, Pages 351-356, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2005.06.031. (https://www.sciencedirect.com/science/article/pii/S037887410500423X) Sofiyan Salim, Muzamil Ahmad, Khan Shoeb Zafar, Abdullah Shafique Ahmad, Fakhrul Islam, Protective effect of Nardostachys jatamansi in rat cerebral ischemia, Pharmacology Biochemistry and Behavior, Volume 74, Issue 2, 2003, Pages 481-486, ISSN 0091-3057, https://doi.org/10.1016/S0091-3057(02)01030-4. Hanumanthachar Joshi and Dr. Milind Parle.Journal of Medicinal Food.Mar 2006.113-118.http://doi.org/10.1089/jmf.2006.9.113 |
| 14 | Desoxo-narchinol A and Narchinol B | 56835095 | Kim KW, Yoon CS, Kim YC, Oh H. Desoxo-narchinol A and Narchinol B Isolated from Nardostachys jatamansi Exert Anti-neuroinflammatory Effects by Up-regulating of Nuclear Transcription Factor Erythroid-2-Related Factor 2/Heme Oxygenase-1 Signaling. Neurotox Res. 2019 Jan;35(1):230-243. doi: 10.1007/s12640-018-9951-x. Epub 2018 Aug 31. PMID: 30168019. |
| 15 | Nardosinone | 168136 | Ko W, Park JS, Kim KW, Kim J, Kim YC, Oh H. Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells. Inflammation. 2018 Aug;41(4):1215-1228. doi: 10.1007/s10753-018-0768-9. PMID: 29616391. Wen J, Liu L, Li J, He Y. A review of nardosinone for pharmacological activities. Eur J Pharmacol. 2021 Oct 5;908:174343. doi: 10.1016/j.ejphar.2021.174343. Epub 2021 Jul 12. PMID: 34265296. Bian LH, Yao ZW, Zhao CB, Li QY, Shi JL, Guo JY. Nardosinone Alleviates Parkinson's Disease Symptoms in Mice by Regulating Dopamine D2 Receptor. Evid Based Complement Alternat Med. 2021 Aug 13;2021:6686965. doi: 10.1155/2021/6686965. PMID: 34426745; PMCID: PMC8380167. |
| 16 | Alpha-patchoulenese | 521710 | -- |
Pharmacological Details
| # | PHARMACOLOGICAL ACTIONS/THERAPEUTIC USES | REFERENCES |
|---|---|---|
| 1 | Anticonvulsant activity | Rao VS, Rao A, Karanth KS. Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats. J Ethnopharmacol. 2005 Dec 1;102(3):351-6. doi: 10.1016/j.jep.2005.06.031. Epub 2005 Aug 10. PMID: 16095854. Pallavi, Jainendra Jain & Puspendra Kumar (2012) Targeting Oxidative Stress in Epilepsy: Study of Effect of Antioxidants on Anticonvulsant Profile of Jatamansone, Journal of Biologically Active Products from Nature, 2:5, 292-301, DOI: 10.1080/22311866.2012.10719137. Bose B, Tripathy D, Chatterjee A, Tandon P, Kumaria S. Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders. Phytomedicine. 2019 Mar 1;55:58-69. doi: 10.1016/j.phymed.2018.08.010. Epub 2018 Aug 8. PMID: 30668444. Pandey MM, Katara A, Pandey G, Rastogi S, Rawat AK. An important Indian traditional drug of ayurveda jatamansi and its substitute bhootkeshi: chemical profiling and antioxidant activity. Evid Based Complement Alternat Med. 2013;2013:142517. doi: 10.1155/2013/142517. Epub 2013 Mar 21. PMID: 23573115; PMCID: PMC3618914. A, Pallavi & Jain, Jainendra & Kumar, Puspendra. (2012). Targeting Oxidative Stress in Epilepsy: Study of Effect of Antioxidants on Anticonvulsant Profile of Jatamansone. Journal of Biologically Active Products from Nature. 2. 10.1080/22311866.2012.10719137. Rao, Vidya & Rao, Anjali & Karanth, K. (2006). Anticonvulsant and neurotoxicity profile of Nardostachys jatamansi in rats. Journal of Ethnopharmacology. 102. 351-6. 10.1016/j.jep.2005.06.031. |
| 2 | Antifungal and antibacterial activity | Kumar VP, Chauhan NS, Padh H, Rajani M. Search for antibacterial and antifungal agents from selected Indian medicinal plants. J Ethnopharmacol. 2006 Sep 19;107(2):182-8. doi: 10.1016/j.jep.2006.03.013. Epub 2006 Mar 27. PMID: 16678369. Sohail, T., Imran, H., Shaukat Dr, S., & Rahman, A.- ur-. (2007). Antibacterial and Antifungal Screening of the Root Extracts of Nardostachys}atamansi. Biological Sciences - PJSIR, 50(4), 261-265. Retrieved from https://www.v2.pjsir.org/index.php/biological-sciences/article/view/986. Singh V, Rana N, Ali M. GC-MS Analysis and Anti-Microbial Activities of Volatile Oil of Nardostachys Jatamansi D.C. Rhizomes Obtained from Haridwar Region, Uttrakhand. Pharmacognosy Journal. 2018;10(2):230-234.
|
| 3 | Effect on Estrogen and hair growth | Bharti M, Shrivastav A, Abid M, Khan NA. A Review on Hair Growth Regulator. JDDT [Internet]. 15Sep.2020 [cited 27Aug.2021];10(5):368-75. Available from: http://www.jddtonline.info/index.php/jddt/article/view/4406. Sahu, Renu & Dhongade, Hemant & Pandey, Ajit & Sahu, Poonam &
Sahu, Varsha & Patel, Dipali & Kashyap, Pranita. (2016). Medicinal
Properties of Nardostachys jatamansi (A Review). Oriental Journal of Chemistry.
32. 859-866.
10.13005/ojc/320211. Singh V, Ali M, Upadhyay S. Study of colouring effect of herbal hair
formulations on graying hair. Pharmacognosy Res. 2015 Jul-Sep;7(3):259-62. doi:
10.4103/0974-8490.157976. PMID: 26130937; PMCID: PMC4471652. |
| 4 | Cardio protective activity | Singh M, Khan MA, Y T K, Ahmad J, Fahmy UA, Kotta S, Alhakamy NA, Ahmad S. Effect of Nardostachys jatamansi DC. on Apoptosis, Inflammation and Oxidative Stress Induced by Doxorubicin in Wistar Rats. Plants (Basel). 2020 Nov 15;9(11):1579. doi: 10.3390/plants9111579. PMID: 33203171; PMCID: PMC7734586. Subashini R, Yogeeta S, Gnanapragasam A, Devaki T. Protective effect of Nardostachys jatamansi on oxidative injury and cellular abnormalities during doxorubicin-induced cardiac damage in rats. J Pharm Pharmacol. 2006 Feb;58(2):257-62. doi: 10.1211/jpp.58.2.0014. PMID: 16451755. Subashini R, Ragavendran B, Gnanapragasam A, Yogeeta SK, Devaki T. Biochemical study on the protective potential of Nardostachys jatamansi extract on lipid profile and lipid metabolizing enzymes in doxorubicin intoxicated rats. Pharmazie. 2007 May;62(5):382-7. PMID: 17557749. Bose B, Tripathy D, Chatterjee A, Tandon P, Kumaria S. Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders. Phytomedicine. 2019 Mar 1;55:58-69. doi: 10.1016/j.phymed.2018.08.010. Epub 2018 Aug 8. PMID: 30668444. Maiwulanjiang M, Chen J, Xin G, Gong AG, Miernisha A, Du CY, Lau KM, Lee PS,
Chen J, Dong TT, Aisa HA, Tsim KW. The volatile oil of Nardostachyos Radix et
Rhizoma inhibits the oxidative stress-induced cell injury via reactive oxygen
species scavenging and Akt activation in H9c2 cardiomyocyte. J Ethnopharmacol.
2014 Apr 28;153(2):491-8. doi: 10.1016/j.jep.2014.03.010. Epub 2014 Mar 12.
PMID: 24632018. |
| 5 | Antiparkinson activity | Li-hua Bian, Zi-wei Yao, Cheng-bowen Zhao, Qiu-yu Li, Jin-li Shi, and Jian-you Guo, Nardosinone Alleviates Parkinson’s Disease Symptoms in Mice by
Regulating Dopamine D2 Receptor,Research Article | Open Access Ahmad M, Yousuf S, Khan MB, Hoda MN, Ahmad AS, Ansari MA, Ishrat T, Agrawal AK,
Islam F. Attenuation by Nardostachys jatamansi of 6-hydroxydopamine-induced
parkinsonism in rats: behavioral, neurochemical, and immunohistochemical
studies. Pharmacol Biochem Behav. 2006 Jan;83(1):150-60. doi:
10.1016/j.pbb.2006.01.005. Epub 2006 Feb 28. PMID: 16500697. |
| 6 | Nootropic activity | Joshi H, Parle M. Nardostachys jatamansi improves learning and memory in mice. J Med Food. 2006 Spring;9(1):113-8. doi: 10.1089/jmf.2006.9.113. PMID: 16579738. Dhiman N, Bhattacharya A. Nardostachys jatamansi (D.Don) DC.-Challenges and opportunities of harnessing the untapped medicinal plant from the Himalayas. J Ethnopharmacol. 2020 Jan 10;246:112211. doi: 10.1016/j.jep.2019.112211. Epub 2019 Sep 15. PMID: 31533076. Hanumanthachar Joshi and Dr. Milind Parle, Nardostachys jatamansi Improves Learning and Memory in Mice Journal of Medicinal Food 2006 9:1, 113-118.
Kasture, S.B., Mane-Deshmukh, R.V. & Arote, S.R. Non-linear dose effect relationship in anxiolytic and nootropic activity of lithium carbonate and Nardostachys jatamansi in rats. Orient Pharm Exp Med 14, 357–362 (2014). https://doi.org/10.1007/s13596-014-0162-6.
Kulkarni R, Girish KJ, Kumar A. Nootropic herbs (Medhya Rasayana) in Ayurveda: An update. Pharmacogn Rev. 2012;6(12):147-153. doi:10.4103/0973-7847.99949.
Saroya A.S., Singh J. (2018) Neuropharmacology of Nardostachys jatamansi DC. In: Pharmacotherapeutic Potential of Natural Products in Neurological Disorders.
Springer, Singapore. https://doi.org/10.1007/978-981-13-0289-3_17. |
| 7 | Neuroprotective activity | Liu QF, Lee JH, Kim YM, Lee S, Hong YK, Hwang S, Oh Y, Lee K, Yun HS, Lee IS, Jeon S, Chin YW, Koo BS, Cho KS. In Vivo Screening of Traditional Medicinal Plants for Neuroprotective Activity against Aβ42 Cytotoxicity by Using Drosophila Models of Alzheimer's Disease. Biol Pharm Bull. 2015;38(12):1891-901. doi: 10.1248/bpb. b15-00459. Epub 2015 Oct 10. PMID: 26458335.
Nadaf M, Joharchi M, Amiri MS. Ethnomedicinal uses of plants for the treatment of nervous disorders at the herbal markets of Bojnord, North Khorasan Province, Iran. Avicenna J Phytomed. 2019 Mar-Apr;9(2):153-163. PMID: 30984580; PMCID: PM C6448544.
Khan MB, Hoda MN, Ishrat T, Ahmad S, Moshahid Khan M, Ahmad A, Yusuf S, Islam
F. Neuroprotective efficacy of Nardostachys jatamansi and crocetin in
conjunction with selenium in cognitive impairment. Neurol Sci. 2012
Oct;33(5):1011-20. doi: 10.1007/s10072-011-0880-1. Epub 2011 Dec 15. PMID:
22170092. |
| 8 | Anticataleptic activity | Rasheed, A.S.; Venkataraman, S.; Jayaveera, K.N.; Mohammed, Y.J.; Phytochemical, Toxicological Evaluation and Anticataleptic Activity of Nardostachysjatamansi Asian Journal of Pharmaceutical and Clinical |
| 9 | Anticancer activity | Chaudhary S, Chandrashekar KS, Pai KS, Setty MM, Devkar RA, Reddy ND, Shoja MH. Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma. BMC Complement Altern Med. 2015 Mar 10; 15:50. doi: 10.1186/s12906-015-0563-1. PMID: 25886964; PMCID: PMC4364107.
Lee GW, Hur W, Kim JH, Park DJ, Kim SM, Kang BY, Sung PS, Yoon SK. Nardostachys
jatamansi Root Extract Attenuates Tumor Progression in Hepatocellular Carcinoma
via Inhibition of ERK/STAT3 Pathways. Anticancer Res. 2021 Apr;41(4):1883-1893.
doi: 10.21873/anticanres.14954. PMID: 33813393. |
| 10 | Anti-pancreatitis Activity | Chaudhary S, Chandrashekar KS, Pai KS, Setty MM, Devkar RA, Reddy ND, Shoja MH. Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma. BMC Complement Altern Med. 2015 Mar 10; 15:50. doi: 10.1186/s12906-015-0563-1. PMID: 25886964; PMCID: PMC4364107.
Lee GW, Hur W, Kim JH, Park DJ, Kim SM, Kang BY, Sung PS, Yoon SK. Nardostachys
jatamansi Root Extract Attenuates Tumor Progression in Hepatocellular Carcinoma
via Inhibition of ERK/STAT3 Pathways. Anticancer Res. 2021 Apr;41(4):1883-1893.
doi: 10.21873/anticanres.14954. PMID: 33813393. |
| 11 | Anti Depression Activity | Jalali S, Zarrinhaghighi A, Sadraei S, Ghasemi Y, Sakhteman A, Faridi P. A System Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi. Curr Drug Metab. 2018;19(5):469-476. doi: 10.2174/1389200219666180305151011. PMID: 29512454.
Bhat MDA, Malik SA. Efficacy of Nardostachys jatamansi (D.Don) DC in essential hypertension: A randomized controlled study. Complement Ther Med. 2020 Sep; 53:102532. doi: 10.1016/j.ctim.2020.102532. Epub 2020 Aug 14. PMID: 33066862.
Li R, Wang ZM, Wang Y, Dong X, Zhang LH, Wang T, Zhu Y, Gao XM, Wu HH, Xu YT. Antidepressant activities and regulative effects on serotonin transporter of Nardostachys jatamansi DC. J Ethnopharmacol. 2021 Mar 25; 268:113601. doi: 10.1016/j.jep.2020.113601. Epub 2020 Nov 18. PMID: 33220358. Cornara L, Ambu G, Trombetta D, Denaro M, Alloisio S, Frigerio J, Labra M, Ghimire G, Valussi M, Smeriglio A. Comparative and Functional Screening of Three Species Traditionally used as Antidepressants: Valeriana officinalis L., Valeriana jatamansi Jones ex Roxb. and Nardostachys jatamansi (D.Don) DC. Plants (Basel). 2020 Aug 5;9(8):994. doi: 10.3390/plants9080994. PMID: 32764268; PMCID: PMC7464919. Dhingra D, Goyal PK. Inhibition of MAO and GABA: probable mechanisms for
antidepressant-like activity of Nardostachys jatamansi DC. in mice. Indian J
Exp Biol. 2008 Apr;46(4):212-8. PMID: 18512329. |
| 12 | Anti-Androgenic Activity | Sandeep PM, Bovee TF, Sreejith K. Anti-Androgenic Activity of
Nardostachys jatamansi DC and Tribulus terrestris L. and Their Beneficial
Effects on Polycystic Ovary Syndrome-Induced Rat Models. Metab Syndr Relat
Disord. 2015 Aug;13(6):248-54. doi: 10.1089/met.2014.0136. Epub 2015 Apr 28.
PMID: 25919204. |
| 13 | Anti-neuroinflammatory activity | Yoon CS, Kim DC, Park JS, Kim KW, Kim YC, Oh H. Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites from Nardostachys jatamansi. Molecules. 2018 Sep 17;23(9):2367. doi: 10.3390/molecules23092367. PMID: 30227591; PMCID: PMC6225174. Kim DC, Park JS, Yoon CS, Kim YC, Oh H. Nardostachin from Nardostachys
jatamansi exerts anti‑neuroinflammatory effects through TLR4/MyD88‑related
suppression of the NF‑κB and JNK MAPK signaling pathways in lipopolysaccharide‑induced
BV2 and primary microglial cells. Mol Med Rep. 2021 Jan;23(1):82. doi:
10.3892/mmr.2020.11720. Epub 2020 Nov 25. PMID:
33236160. Bae GS, Heo KH, Choi SB, Jo IJ, Kim DG, Shin JY, Seo SH, Park KC, Lee DS, Oh H, Kim YC, Song HJ, Shin BC, Park SJ. Beneficial Effects of Fractions of Nardostachys jatamansi on Lipopolysaccharide-Induced Inflammatory Response. Evid Based Complement Alternat Med. 2014; 2014:837835. doi: 10.1155/2014/837835. Epub 2014 Mar 30. PMID: 24795771; PMCID: PMC3985203. Kim KW, Yoon CS, Kim YC, Oh H. Desoxo-narchinol A and Narchinol B Isolated from Nardostachys jatamansi Exert Anti-neuroinflammatory Effects by Up-regulating of Nuclear Transcription Factor Erythroid-2-Related Factor 2/Heme Oxygenase-1 Signaling. Neurotox Res. 2019 Jan;35(1):230-243. doi: 10.1007/s12640-018-9951-x. Epub 2018 Aug 31. PMID: 30168019. Liu H, Liu D, Jiang
MY, Zhao XD, Li RT, Li HM. Iridoids from Valeriana jatamansi with
anti-inflammatory and antiproliferative properties. Phytochemistry. 2021 Apr; 184:112681. doi: 10.1016/j.phytochem.2021.112681. Epub 2021 Feb 4. PMID:
33548771. |
| 14 | Gastric Ulcer | Memariani Z, Hajimahmoodi M, Minaee B, Khodagholi F, Yans A, Rahimi R,
Amin G, Moghaddam G, Toliyat T, Sharifzadeh M. Protective Effect of a
Polyherbal Traditional Formula Consisting of Rosa damascena Mill., Glycyrrhiza
glabra L. And Nardostachys jatamansi DC., Against Ethanol-induced Gastric
Ulcer. Iran J Pharm Res. 2017 Spring;16(2):694-707. PMID: 28979324; PMCID:
PMC5603879. |
| 15 | Anti diabetes activity | Song MY, Bae UJ, Lee BH, Kwon KB, Seo EA, Park SJ, Kim MS, Song HJ, Kwon KS, Park JW, Ryu DG, Park BH. Nardostachys jatamansi extract protects against cytokine-induced beta-cell damage and streptozotocin-induced diabetes. World J Gastroenterol. 2010 Jul 14;16(26):3249-57. doi: 10.3748/wjg. v16.i26.3249. PMID: 20614480; PMCID: PMC2900716. Bose B,
Tripathy D, Chatterjee A, Tandon P, Kumaria S. Secondary metabolite profiling,
cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of
Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and
cognitive disorders. Phytomedicine. 2019 Mar 1; 55:58-69. doi:
10.1016/j.phymed.2018.08.010. Epub 2018 Aug 8. PMID: 30668444. |
| 16 | Cerebral ischemia | Salim S, Ahmad M, Zafar KS, Ahmad AS, Islam F. Protective effect of
Nardostachys jatamansi in rat cerebral ischemia. Pharmacol Biochem Behav. 2003
Jan;74(2):481-6. doi: 10.1016/s0091-3057(02)01030-4. PMID: 12479970. |
| 17 | Antiarrhythmic activity | ARORA RB, MADAN BR. Antiarrhythmics. III. Antiarrhythmic activity of
Nardostachys jatamansi (an Indian indigenous drug). Indian J Med Res. 1956
Apr;44(2):259-69. PMID: 13331599. |
| 18 | acetylcholinesterase inhibitory activity | Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res. 2007 Dec;21(12):1142-5. doi: 10.1002/ptr.2224. PMID: 17639556. Mathew M, Subramanian S. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders. PLoS One. 2014 Jan 23;9(1): e86804. doi: 10.1371/journal.pone.0086804. PMID: 24466247; PMCID: PMC3900633. Vinutha
B, Prashanth D, Salma K, Sreeja SL, Pratiti D, Padmaja R, Radhika S, Amit A,
Venkateshwarlu K, Deepak M. Screening of selected Indian medicinal plants for
acetylcholinesterase inhibitory activity. J Ethnopharmacol. 2007 Jan
19;109(2):359-63. doi: 10.1016/j.jep.2006.06.014. Epub 2006 Aug 4. PMID:
16950584. |
Marketed Products
| # | AVALAIBLE PRODUCTS | MANUFACTURERS AND SUPPLIERS | URL |
|---|---|---|---|
| 1 | VITAWIN JATAMANSI Capsules for Brain Tonic | Green cross health Innovation | Open Url |
Traditional Indian Medicinal Formulations
| # | AYURVEDIC FORMULATIONS (TKDL) | UNANI FORMULATIONS (TKDL) | SIDDHA FORMULATIONS (TKDL) |
|---|---|---|---|
| 1 | Shringarabhram | Tiryaaq-e- Farooq | Thalisapathiri Chooranam |
Other Polyherbal Formulations
| # | POLYHERBAL FORMULATIONS | CITATIONS ON POLYHERBAL FORMULATIONS (PROPERTIES & ACTIVITIES) |
|---|---|---|
| 1 | Ayush 56- Dhiman, Kamini & Srikanth, Narayanam & Maheshwar, T & Khanduri, Shruti & Yadav, Babita & Sarada, Ota & Singh, Renu & Goel, Sumeet. (2018). Glimpses of CCRAS contributions 50 Glorious years: Clinical Research Drug Development Vol. 1. | Shah J, Goyal R. Investigation of neuropsychopharmacological effects of a polyherbal formulation on the learning and memory process in rats. J Young Pharm. 2011 Apr;3(2):119-24. doi: 10.4103/0975-1483.80296. PMID: 21731356; PMCID: PMC3122040. |
Market Overview
Global End Use Market
Pharmaceuticals, Cosmetics, Folk uses
Available Global Market
Nepal, India, Pakistan, Bhutan, Myanmar and Southeast China
Global Manufacturer Extract
-
Distribution in IORA Countries
Bangladesh
Trade Data
Source Supply
Alpine temperate forests
Trade Name
Spike Nard, Jatamansi, Balchad and Balehand
Annual Consumption (in MT)
-
Medicinal Plants Traders from India
| # | ADDRESSES OF MEDICINAL PLANTS TRADERS |
|---|---|
| 1 | OSR Ayurveda 238, 2nd Floor, Padam Nagar, Near Axis Bank, Padam Nagar, Kishan Ganj, Delhi - 110007, India 08048977391 |
Adulterant/Substitute
Adulterant - Selinum vaginatum and S. Candollei