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Withania coagulans
BOTANICAL DETAILS OF PLANT
Synonyms
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Classification
Kingdom
Plantae
Subkingdom
Superdivision
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Division
Streptophyta
Class
Equisetopsida
Subclass
Magnoliidae
Order
Solanales
Family
Solanaceae
Genus
Withania
Species
Withania coagulans
Plant Description
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Habit/Life Form
--
DISTRIBUTION OF SPECIES IN INDIA
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Plant Parts Used
-
System of Medicine
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Intended Use
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Traditional Application
Phytochemical Details
| # | Phytochemical Constituents | PUBCHEM CID | References |
|---|---|---|---|
| 1 | Coagulin | 10672645 | Maurya, Rakesh. |
| 2 | 14,15β-Epoxywithanolide I | 274336262 | Maurya, Rakesh. |
| 3 | oxowitha-3,5,24-trienolide | 73699089 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 4 | 17β-Hydroxywithanolide K | 1782565 | Maurya, Rakesh. |
| 5 | oxowitha-2,5,24-trienolide) | 102150374 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 6 | Coagulin B | 10599742 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 7 | Coagulin C | 44562952 | Maurya, Rakesh. |
| 8 | Coagulin D | 162368375 | Maurya, Rakesh. |
| 9 | Coagulin E | 15341418 | Maurya, Rakesh. |
| 10 | Coagulin F | 9644072 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 11 | Coagulin G | 24941992 | Maurya, Rakesh. |
| 12 | Coagulin H | 10553985 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 13 | Ergosta-5,25-diene-3β,24ξ-diol | 472127310 | Maurya, Rakesh. |
| 14 | Coagulin I | 10672584 | Maurya, Rakesh. |
| 15 | Coagulin J | 10600450 | Maurya, Rakesh. |
| 16 | Coagulin K | 10841504 | Maurya, Rakesh. |
| 17 | Coagulanolide | 44562997 | Maurya, Rakesh. |
| 18 | Coagulin M | 10672645 | Maurya, Rakesh. |
| 19 | Withacoagulin | 12115994 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 20 | Coagulin N | 10675736 | Maurya, Rakesh. |
| 21 | Coagulin O | 10770343 | Maurya, Rakesh. |
| 22 | Coagulin S | 21629588 | Maurya, Rakesh. |
| 23 | Coagulin P | 10794094 | Maurya, Rakesh. |
| 24 | Withaferin A | 265237 | Maurya, Rakesh. |
| 25 | Coagulin Q | 162623730 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 26 | Withanolide | 53477765 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 27 | Coagulin R | 15977628 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 28 | Withacoagin | 14236709 | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. |
| 29 | Coagulanolide | 44562997 | Khan, M.I.; Maqsood, M.; Saeed, R.A.; Alam, A.; Sahar, A.; Kieliszek, M.; Miecznikowski, A.; Muzammil, H.S.; Aadil, R.M. Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review. Molecules 2021, 26, 6881. https://doi.org/10.3390/ molecules26226881 |
| 30 | Ajugin A | 21668783 | Khan, M.I.; Maqsood, M.; Saeed, R.A.; Alam, A.; Sahar, A.; Kieliszek, M.; Miecznikowski, A.; Muzammil, H.S.; Aadil, R.M. Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review. Molecules 2021, 26, 6881. https://doi.org/10.3390/ molecules26226881 |
| 31 | Ajugin E | 101010478 | Khan, M.I.; Maqsood, M.; Saeed, R.A.; Alam, A.; Sahar, A.; Kieliszek, M.; Miecznikowski, A.; Muzammil, H.S.; Aadil, R.M. Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review. Molecules 2021, 26, 6881. https://doi.org/10.3390/ molecules26226881 |
| 32 | Coagulansin A | 101883243 | Khan, M.I.; Maqsood, M.; Saeed, R.A.; Alam, A.; Sahar, A.; Kieliszek, M.; Miecznikowski, A.; Muzammil, H.S.; Aadil, R.M. Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review. Molecules 2021, 26, 6881. https://doi.org/10.3390/ molecules26226881 |
| 33 | Withacoagulin A | 12115994 | Khan, M.I.; Maqsood, M.; Saeed, R.A.; Alam, A.; Sahar, A.; Kieliszek, M.; Miecznikowski, A.; Muzammil, H.S.; Aadil, R.M. Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review. Molecules 2021, 26, 6881. https://doi.org/10.3390/ molecules26226881 |
Pharmacological Details
| # | PHARMACOLOGICAL ACTIONS/THERAPEUTIC USES | REFERENCES |
|---|---|---|
| 1 | Antitumour activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160 Maqsood, Muhammad, et al. "In vitro anticancer activities of Withania coagulans against HeLa, MCF-7, RD, RG2, and INS-1 cancer cells and phytochemical analysis." Integrative medicine research 7.2 (2018): 184-191. Ahmad, Rumana, et al. "Evaluation of apoptotic activity of Withania coagulans methanolic extract against human breast cancer and Vero cell lines." Journal of Ayurveda and integrative medicine 8.3 (2017): 177-183. Neogi, Partha, et al. "Withacoagin, a new withanolide from Withania coagulans roots." Bulletin of the Chemical Society of Japan 61.12 (1988): 4479-4481. Tripathi, Deepika, et al. "Green and cost effective synthesis of silver nanoparticles from endangered medicinal plant Withania coagulans and their potential biomedical properties." Materials Science and Engineering: C 100 (2019): 152-164. Khan, Muhammad Issa, et al. "Phytochemistry, food application, and therapeutic potential of the medicinal plant (Withania coagulans): A review." Molecules 26.22 (2021): 6881. Jain, Rohit, Sumita Kachhwaha, and S. L. Kothari. "Phytochemistry, pharmacology, and biotechnology of Withania somnifera and Withania coagulans: A review." Journal of Medicinal Plants Research 6.41 (2012): 5388-5399. Qureshi, Sadia, et al. "Apoptotic activity of Withania coagulans methanolic extract in cancer cells using rats and HeLa cell line." Pak J Med Health Sci 9 (2015): 123-127. Barad, Roshni, et al. "Withania coagulans and Psidium guajava-an overview." International Research Journal of Pharmaceutical and Applied Sciences 3.3 (2013): 42-47. Rai, Mahendra, et al. "Anticancer activities of Withania somnifera: Current research, formulations, and future perspectives." Pharmaceutical biology 54.2 (2016): 189-197.
Aljohny, Bassam Oudh, Yasir Anwar, and Shahid Ali Khan. "In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans." Zeitschrift für Naturforschung C 77.7-8 (2022): 263-270. |
| 2 | Cytotoxic activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Maqsood, Muhammad, et al. "In vitro anticancer activities of Withania coagulans against HeLa, MCF-7, RD, RG2, and INS-1 cancer cells and phytochemical analysis." Integrative medicine research 7.2 (2018): 184-191. Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Hemalatha, S., Rajesh Kumar, and Manish Kumar. "Withania coagulans Dunal: A review." Pharmacognosy Reviews 2.4 (2008): 351. Jain, Rohit, Sumita Kachhwaha, and S. L. Kothari. "Phytochemistry, pharmacology, and biotechnology of Withania somnifera and Withania coagulans: A review." Journal of Medicinal Plants Research 6.41 (2012): 5388-5399. |
| 3 | Immunomodulating activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Hoda, Quaisul, et al. "Antihyperglycaemic and antihyperlipidaemic effect of poly-constituents, in aqueous and chloroform extracts, of Withania coagulans Dunal in experimental type 2 diabetes mellitus in rats." Human & experimental toxicology 29.8 (2010): 653-658. Jain, Rohit, Sumita Kachhwaha, and S. L. Kothari. "Phytochemistry, pharmacology, and biotechnology of Withania somnifera and Withania coagulans: A review." Journal of Medicinal Plants Research 6.41 (2012): 5388-5399. Yasir, Mohammad, et al. "Hypoglycemic and antihyperglycemic effects of different extracts and combinations of Withania coagulans dunal and Acacia arabica lamk in normal and alloxan induced diabetic rats." Pharmacognosy Communications 2.2 (2012): 61-66. Khan, Fearoz, et al. "Wathania Coagulans Derivatives As Potent Inhibitors Against HMG COA Redutase." BMC Journal of Medical Sciences 3.1 (2022): 1-6. |
| 4 | Antimicrobial activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Sudhanshu, Mittal S., N. I. D. H. I. Rao, and E. K. T. A. Menghani. "Phytochemical and antimicrobial activity of Withania coagulans (Stocks) Dunal (Fruit)." Int. J. Pharm. Pharmac. Sci 4 (2012): 387-389. Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Asghar, Anam, et al. "Development, characterization and evaluation of in vitro anti-inflammatory activity of Withania coagulans extract and extract loaded microemulsion." 2021,Pakistan Journal of Pharmaceutical Sciences 34. Ahmad, Rumana, et al. "Evaluation of apoptotic activity of Withania coagulans methanolic extract against human breast cancer and Vero cell lines." Journal of Ayurveda and integrative medicine 8.3 (2017): 177-183. Peerzade, Nazneen, Nida Sayed, and Nivedita Das. "Antimicrobial and phytochemical screening of methanolic fruit extract of Withania coagulans L. Dunal for evaluating the antidiabetic activity." Pharma Innov. J 7 (2018): 197-204. Keshari, Anand, et al. "Synergistic activity of green silver nanoparticles with antibiotics." Nanomedicine Research Journal 5.1 (2020): 44-54. |
| 5 | Central nervous system | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Budhiraja, R. D., S. Bala, and K. N. Garg. "Pharmacological investigations on fruits of Withania coagulans, Dunal." Planta medica 32.06 (1977): 154-157. Gupta, Prakash Chandra. "Withania coagulans Dunal-an overview." International Journal of Pharmaceutical Sciences Review and Research 12.2 (2012): 68-71. Mathur, Deepika, R. C. Agrawal, and Vinoy Shrivastava. "Phytochemical screening and determination of antioxidant potential of fruits extracts of Withania coagulans." (2011), Recent Research in Science and Technology 3.11. Barad, Roshni, et al. "Withania coagulans and Psidium guajava-an overview." International Research Journal of Pharmaceutical and Applied Sciences 3.3 (2013): 42-47. Khan, Muhammad Issa, et al. "Phytochemistry, food application, and therapeutic potential of the medicinal plant (Withania coagulans): A review." Molecules 26.22 (2021): 6881. Maher, Saima, et al. "Isolation of antidiabetic withanolides from Withania coagulans Dunal and their in vitro and in silico validation." Biology 9.8 (2020): 197. Asghar, Anam, et al. "Co-combination of pregabalin and Withania coagulans-extract-loaded topical gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury for neuropathic pain in animal model." Molecules 27.14 (2022): 4433. Mathur, Deepika, and R. C. Agrawal. "Evaluation of in vivo antimutagenic potential of fruits extracts of Withania coagulans." Der Pharma Chemica 3.4 (2011): 373-376. Kamdi, Amit Shankarrao, et al. "The motor coordination activity of aqueous extract of withania coagulans fruits in swiss albino mice by rota rod test." (2020), European Journal of Medical and Health Sciences 2.3. Siddiqui, H. H., A. H. Israeli, and S. M. J. S. Qadry. "STUDIES ON WITHANIA COAGULANS DUNAL (PART I)." Planta Medica 11.02 (1963): 145-153. Jain, Rohit, et al. "Adventitious shoot regeneration and in vitro biosynthesis of steroidal lactones in Withania coagulans (Stocks) Dunal." Plant Cell, Tissue and Organ Culture (PCTOC) 105 (2011): 135-140. |
| 6 | Antidepressant activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Gosavi, Devesh D., and Amit S. Kamdi. "The antidepressant activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by tail suspension test." National Journal of Physiology, Pharmacy and Pharmacology 10.7 (2020): 527-529. Kamdi, Amit S., et al. "The antidepressant activity of the alcoholic extract of Withania coagulans fruits in Swiss albino mice by forced swimming test." National Journal of Physiology, Pharmacy and Pharmacology 9.9 (2019): 904-904. Ahmad, Naseer, et al. "CNS depressant and analgesic effects of Withania coagulans (Stocks) Dunal fruits collected from Khuzdar district of Balochistan, Pakistan." Pure and Applied Biology (PAB) 6.2 (2017): 636-644. Kamdi, Amit Shankarrao, et al. "The motor coordination activity of aqueous extract of withania coagulans fruits in swiss albino mice by rota rod test." (2020), European Journal of Medical and Health Sciences 2.3 Mirjalili, Mohammad Hossein, et al. "Steroidal lactones from Withania somnifera, an ancient plant for novel medicine." Molecules 14.7 (2009): 2373-2393. Gupta, Girdhari Lal, and A. C. Rana. "PHCOG MAG.: Plant review Withania somnifera (Ashwagandha): A review." Pharmacognosy Reviews 1.1 (2007): 129-136. Lopresti, Adrian L., Peter D. Drummond, and Stephen J. Smith. "A randomized, double-blind, placebo-controlled, crossover study examining the hormonal and vitality effects of ashwagandha (Withania somnifera) in aging, overweight males." American journal of men's health 13.2 (2019): 1557988319835985. |
| 7 | Hypolipidaemic activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Hemalatha, S., et al. "Hypolipidemic activity of aqueous extract of Withania coagulans Dunal in albino rats." Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 20.7 (2006): 614-617. Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Hemalatha, S., Rajesh Kumar, and Manish Kumar. "Withania coagulans Dunal: A review." Pharmacognosy Reviews 2.4 (2008): 351. Hemalatha, S., et al. "Hypoglycemic activity of Withania coagulans Dunal in streptozotocin induced diabetic rats." Journal of Ethnopharmacology 93.2-3 (2004): 261-264. Datta, Ankur, et al. "Antidiabetic and antihyperlipidemic activity of hydroalcoholic extract of Withania coagulans Dunal dried fruit in experimental rat models." Journal of Ayurveda and integrative medicine 4.2 (2013): 99. Lateef, Tooba, and Qureshi SA. "Centratherum anthelminticum and Withania coagulans improves lipid profile and oxidative stress in triton X-100 induced hyperlipidemic rabbits." Group 1.11.36 (2020): 1-22. Maurya, Rakesh, Amar B. Singh, and Arvind K. Srivastava. "Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity." Bioorganic & medicinal chemistry letters 18.24 (2008): 6534-6537. Prasad, S. K., et al. "Pharmacognostical standardization of Withania coagulans Dunal." Pharmacognosy journal 2.11 (2010): 386-394. |
| 8 | Cardiovascular effects | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Gupta, Prakash Chandra. "Withania coagulans Dunal-an overview." International Journal of Pharmaceutical Sciences Review and Research 12.2 (2012): 68-71. Budhiraja, R. D., S. Sudhir, and K. N. Garg. "Cardiovascular effects of a withanolide from Withania coagulans, dunal fruits." Indian journal of physiology and pharmacology 27.2 (1983): 129-134. Hemalatha, S., Rajesh Kumar, and Manish Kumar. "Withania coagulans Dunal: A review." Pharmacognosy Reviews 2.4 (2008): 351. Shukla, Kirtikar, et al. "Ameliorative effect of Withania coagulans on dyslipidemia and oxidative stress in nicotinamide–streptozotocin induced diabetes mellitus." Food and Chemical Toxicology 50.10 (2012): 3595-3599. Lateef, Tooba, and Shamim A. Qureshi. "Ameliorative effect of Withania coagulans on experimentally-induced hyperlipidemia in rabbits." J. Nat. Remedies 14.1 (2014): 83-88. Jaiswal, Dolly, Prashant Kumar Rai, and Geeta Watal. "Antidiabetic effect of Withania coagulans in experimental rats." Indian Journal of Clinical Biochemistry 24 (2009): 88-93. Shukla, Kirtikar, et al. "The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats." Journal of medicinal food 15.8 (2012): 718-725. Maurya, Rakesh, Amar B. Singh, and Arvind K. Srivastava. "Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity." Bioorganic & medicinal chemistry letters 18.24 (2008): 6534-6537. Lateef, Tooba, and Qureshi SA. "Centratherum anthelminticum and Withania coagulans improves lipid profile and oxidative stress in triton X-100 induced hyperlipidemic rabbits." Group 1.11.36 (2020): 1-22. |
| 9 | Hepatoprotective activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Qureshi, Shamim Akhtar, et al. "Presence of gallic acid and rutin improve the hepatoprotective strength of Withania coagulans." Pak. J. Pharm. Sci 32.1 (2019): 301-308. Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Jain, Rohit, Sumita Kachhwaha, and S. L. Kothari. "Phytochemistry, pharmacology, and biotechnology of Withania somnifera and Withania coagulans: A review." Journal of Medicinal Plants Research 6.41 (2012): 5388-5399. Khan, Fearoz, et al. "Wathania Coagulans Derivatives As Potent Inhibitors Against HMG COA Redutase." BMC Journal of Medical Sciences 3.1 (2022): 1-6. Hemalatha, S., Rajesh Kumar, and Manish Kumar. "Withania coagulans Dunal: A review." Pharmacognosy Reviews 2.4 (2008): 351. Jaiswal, Dolly, Prashant Kumar Rai, and Geeta Watal. "Antidiabetic effect of Withania coagulans in experimental rats." Indian Journal of Clinical Biochemistry 24 (2009): 88-93. |
| 10 | anti-inflammatory activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Gupta, Prakash Chandra. "Withania coagulans Dunal-an overview." International Journal of Pharmaceutical Sciences Review and Research 12.2 (2012): 68-71. Hemalatha, S., Rajesh Kumar, and Manish Kumar. "Withania coagulans Dunal: A review." Pharmacognosy Reviews 2.4 (2008): 351. Gupta, Rupal, Tareeka Sonawane, and Sandeep Pai. "An overview on pharmaceutical properties and biotechnological advancement of Withania coagulans." Advances in Traditional Medicine 22.4 (2022): 673-683. Budhiraja, R. D., S. Bala, and K. N. Garg. "Pharmacological investigations on fruits of Withania coagulans, Dunal." Planta medica 32.06 (1977): 154-157. Sharma, Sonam, Apurva Joshi, and Siva Hemalatha. "Protective effect of Withania coagulans fruit extract on cisplatin-induced nephrotoxicity in rats." Pharmacognosy research 9.4 (2017): 354. Sudhanshu, Mittal S., N. I. D. H. I. Rao, and E. K. T. A. Menghani. "Phytochemical and antimicrobial activity of Withania coagulans (Stocks) Dunal (Fruit)." Int. J. Pharm. Pharmac. Sci 4 (2012): 387-389 Salwaan, Chetan, et al. "Investigation of the pharmacognostical, phytochemical and antioxidant studies of plant Withania coagulans dunal." Journal of Pharmacognosy and Phytochemistry 1.3 (2012): 32-39. Asghar, Anam, et al. "Preparation, characterization of pregabalin and Withania coagulans extract-loaded topical gel and their comparative effect on burn injury." Gels 8.7 (2022): 402. |
| 11 | Antihyperglycaemic activity | Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Hemalatha, S., et al. "Hypoglycemic activity of Withania coagulans Dunal in streptozotocin induced diabetic rats." Journal of Ethnopharmacology 93.2-3 (2004): 261-264. Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Hemalatha, S., Rajesh Kumar, and Manish Kumar. "Withania coagulans Dunal: A review." Pharmacognosy Reviews 2.4 (2008): 351. Hoda, Quaisul, et al. "Antihyperglycaemic and antihyperlipidaemic effect of poly-constituents, in aqueous and chloroform extracts, of Withania coagulans Dunal in experimental type 2 diabetes mellitus in rats." Human & experimental toxicology 29.8 (2010): 653-658. Kumar Bharti, Sudhanshu, et al. "In vivo and in silico investigation of antidiabetic activity of fruit of Withania coagulans Dunal." Current hypertension reviews 11.2 (2015): 143-158. Maher, Saima, et al. "Isolation of antidiabetic withanolides from Withania coagulans Dunal and their in vitro and in silico validation." Biology 9.8 (2020): 197. Datta, Ankur, et al. "Antidiabetic and antihyperlipidemic activity of hydroalcoholic extract of Withania coagulans Dunal dried fruit in experimental rat models." Journal of Ayurveda and integrative medicine 4.2 (2013): 99. Shukla, Kirtikar, et al. "The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats." Journal of medicinal food 15.8 (2012): 718-725. Jaiswal, Dolly, Prashant Kumar Rai, and Geeta Watal. "Hypoglycemic and antidiabetic effects of Withania coagulans fruit ethanolic extract in normal and streptozotocin‐induced diabetic rats." Journal of food biochemistry 34.4 (2010): 764-778. Bharti, Sudhanshu Kumar, et al. "Antidiabetic effect of aqueous extract of Withania coagulans flower in Poloxamer-407 induced type 2 diabetic rats." Journal of Medicinal Plants Research 6.45 (2012): 5706-5713. |
| 12 | Antihyperlipidemic activity | Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Saxena, Bhagawati. "Anti-hyperlipidemic activity of Withania coagulans in streptozotocininduced diabetes: A potent anti-atherosclerotic agent." (2010),Drug Discoveries & Therapeutics 4.5 Datta, Ankur, et al. "Antidiabetic and antihyperlipidemic activity of hydroalcoholic extract of Withania coagulans Dunal dried fruit in experimental rat models." Journal of Ayurveda and integrative medicine 4.2 (2013): 99. Lateef, Tooba, and Shamim A. Qureshi. "Ameliorative effect of Withania coagulans on experimentally-induced hyperlipidemia in rabbits." J. Nat. Remedies 14.1 (2014): 83-88. Gupta, Prakash Chandra. "Withania coagulans Dunal-an overview." International Journal of Pharmaceutical Sciences Review and Research 12.2 (2012): 68-71. Lateef, Tooba, and Qureshi SA. "Centratherum anthelminticum and Withania coagulans improves lipid profile and oxidative stress in triton X-100 induced hyperlipidemic rabbits." Group 1.11.36 (2020): 1-22. Maurya, Rakesh, Amar B. Singh, and Arvind K. Srivastava. "Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity." Bioorganic & medicinal chemistry letters 18.24 (2008): 6534-6537. |
| 13 | Diuretic effect | Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Gupta, Prakash Chandra. "Withania coagulans Dunal-an overview." International Journal of Pharmaceutical Sciences Review and Research 12.2 (2012): 68-71. Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Maurya, Rakesh. "Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy." Journal of pharmacy and pharmacology 62.2 (2010): 153-160. Khodaei, Maryam, Mehrana Jafari, and Mitra Noori. "Remedial use of withanolides from Withania coagolans (Stocks) Dunal." Adv Life Sci 2.1 (2012): 6-19. Quaisul, Hoda. "In vivo effect of withacoagulin and coagulin C isolated from Withania coagulans Dunal fruits on blood pressure of albino rats." World Journal of Advanced Research and Reviews 4.2 (2019): 027-032. Jain, Rohit, Sumita Kachhwaha, and S. L. Kothari. "Phytochemistry, pharmacology, and biotechnology of Withania somnifera and Withania coagulans: A review." Journal of Medicinal Plants Research 6.41 (2012): 5388-5399. Nur‐e‐Alam, M., et al. "A Novel Dimeric Podophyllotoxin‐Type Lignan and a New Withanolide from Withania coagulans." Helvetica chimica acta 86.3 (2003): 607-614. Ahmad, Naseer, et al. "CNS depressant and analgesic effects of Withania coagulans (Stocks) Dunal fruits collected from Khuzdar district of Balochistan, Pakistan." Pure and Applied Biology (PAB) 6.2 (2017): 636-644. Nazish, Hafiz Adeel, et al. "Efficacy of Withania coagulans fruit extract as a coagulant for Mozzarella cheese at different coagulation temperatures from curd formation to pizza top." Journal of Food Processing and Preservation 46.12 (2022): e17167. |
| 14 | Wound healing activity | Gupta, Vandana, and Bipin Bihari Keshari. "Withania coagulans Dunal (paneer doda): A review." International Journal of Ayurvedic and Herbal Medicine 3.5 (2013): 1330-1336. Prasad, S. K., et al. "Wound healing activity of Withania coagulans in streptozotocin-induced diabetic rats." Pharmaceutical biology 48.12 (2010): 1397-1404. Hemalatha, S., Rajesh Kumar, and Manish Kumar. "Withania coagulans Dunal: A review." Pharmacognosy Reviews 2.4 (2008): 351. Gupta, Prakash Chandra. "Withania coagulans Dunal-an overview." International Journal of Pharmaceutical Sciences Review and Research 12.2 (2012): 68-71. Maqsood, Muhammad, et al. "In vitro anticancer activities of Withania coagulans against HeLa, MCF-7, RD, RG2, and INS-1 cancer cells and phytochemical analysis." Integrative medicine research 7.2 (2018): 184-191. Asghar, Anam, et al. "Preparation, characterization of pregabalin and Withania coagulans extract-loaded topical gel and their comparative effect on burn injury." Gels 8.7 (2022): 402. Salehi, Mahmoud, et al. "Purification and characterization of a milk-clotting aspartic protease from Withania coagulans fruit." International Journal of Biological Macromolecules 98 (2017): 847-854. Ojha, Shreesh, et al. "Withania coagulans fruit extract reduces oxidative stress and inflammation in kidneys of streptozotocin-induced diabetic rats." Oxidative medicine and cellular longevity 2014 (2014). |
Market Overview
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