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Betula utilis
BOTANICAL DETAILS OF PLANT
Synonyms
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Classification
Kingdom
Plantae
Subkingdom
Superdivision
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Division
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Class
Equisetopsida
Subclass
Magnoliidae
Order
Fagales
Family
Betulaceae
Genus
Betula
Species
Betula utilis
Plant Description
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Habit/Life Form
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DISTRIBUTION OF SPECIES IN INDIA
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Plant Parts Used
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System of Medicine
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Intended Use
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Traditional Application
Phytochemical Details
| # | Phytochemical Constituents | PUBCHEM CID | References |
|---|---|---|---|
| 1 | Betufernanediol A | 14531469 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 2 | Platyphylloside | 9826264 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 3 | Monogynol A | 10003607 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 4 | Karachic acid | 275187271 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 5 | Betulafolienetetraol | 51627153 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 6 | Arbutin | 440936 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 7 | Ovalifoliolide B | 275182150 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 8 | Hydroxyhopanone | 21582894 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 9 | Platyphyllin A | 11407816 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 10 | Ovalifoliolide A | 275182149 | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. |
| 11 | Hentriacontane | 12410 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 12 | Quercetin | 5280343 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 13 | Taraxeryl acetate | 94225 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 14 | Cyanidin diglucoside | 441688 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 15 | Margaric acid | 10465 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 16 | Methyl sterculate | 115261 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 17 | cyclopropanoids | 37389246 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 18 | anthraquinone | 6780 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 19 | Hydroxycitric acid | 123908 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 20 | Hibiscus acid | 9856782 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 21 | Tiliroside | 5320686 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 22 | Isomagnolol | 159137 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 23 | Asperoside | 3085030 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
| 24 | Strebloside | 21123718 | Khristi, Vincenta, and V. H. Patel. "Therapeutic potential of Hibiscus rosa sinensis: A review." International journal of nutrition and dietetics 4.2 (2016): 105-123. |
Pharmacological Details
| # | PHARMACOLOGICAL ACTIONS/THERAPEUTIC USES | REFERENCES |
|---|---|---|
| 1 | Anticancer Activity | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Mishra, Tripti, et al. "Isolation, characterization and anticancer potential of cytotoxic triterpenes from Betula utilis bark." PloS one 11.7 (2016): e0159430. Wani, Zishan Ahmad, and Shreekar Pant. "Betula utilis D. Don: an ecologically and economically important timberline species of himalayan region in jeopardy." The Botanical Review (2021): 1-15. Mir, Naseer Ahmad, et al. "Ecology and Silviculture of Betula species in the Himalayan Region." (2016): 36-41. Singh, Saumya, et al. "Betula utilis: A potential herbal medicine." Int J Pharm Biol Arch 3.3 (2012): 493-498. Lee, Joo-Eun, et al. "Platyphylloside isolated from Betula platyphylla is antiproliferative and induces apoptosis in colon cancer and leukemic cells." Molecules 24.16 (2019): 2960. Singh, Saumya, et al. "A comparitive study of antioxidant properties and phytochemical composition of Trapa bispinosa, Trigonella foenum-graecum, Syzygium cumini and Betula utilis." Int J Pharm Sci Rev Res 38.2 (2016): 83-88. Shaikh, A. M., et al. "Medicinal plants as potential source of anticancer agents: a review." Journal of Pharmacognosy and Phytochemistry 5.2 (2016): 291-295. Kala, Chandra Prakash. "Uses, Population status and management of Betula utilis." Applied Ecology and Environmental Sciences 6.3 (2018): 79-83. |
| 2 | Antiinflammatory Activity | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Kumaraswamy, M. V., and S. Satish. "Free radical scavenging activity and lipoxygenase inhibition of Woodfordia fructicosa Kurz and Betula utilis Wall." African Journal of Biotechnology 7.12 (2008): 2013-2016. Vishwakarma, Rahul Kumar, Aaysha Negi, and Devendra Singh Negi. "Anti-oxidant, COX inhibition activity of different extract of bark of Betula utilis and molecular docking analysis of its phytochemicals against COX-1 and COX-2 isoenzyme." Materials Today: Proceedings 57 (2022): 251-258. Shah, Samir K., Kruti M. Patel, and Pinal M. Vaviya. "Evaluation of antiurolithiatic activity of Betula utilis in rats using ethylene glycol model." Asian Journal of Pharmaceutical Research 7.2 (2017): 81-87. Singh, Saumya, et al. "A comparitive study of antioxidant properties and phytochemical composition of Trapa bispinosa, Trigonella foenum-graecum, Syzygium cumini and Betula utilis." Int J Pharm Sci Rev Res 38.2 (2016): 83-88. Wani, Zishan Ahm ad, and Shreekar Pant. "Betula utilis D. Don: an ecologically and economically important timberline species of himalayan region in jeopardy." The Botanical Review (2021): 1-15. Singh, Saumya, et al. "Betula utilis: A potential herbal medicine." Int J Pharm Biol Arch 3.3 (2012): 493-498. Radha, et al. "Evaluation of nutritional, phytochemical, and mineral composition of selected medicinal plants for therapeutic uses from cold desert of Western Himalaya." Plants 10.7 (2021): 1429. Ou-Yang, Ting, et al. "Novel compounds discovery approach based on UPLC-QTOF-MS/MS chemical profile reveals birch bark extract anti-inflammatory,-oxidative, and-proliferative effects." Journal of Ethnopharmacology 306 (2023): 116148. Fahad, Shah, and Asghari Bano. "Ethnobotanical and physiological studies of some endangered plant species collected from two different altitudes in Gilgit Baltistan." Pak. J. Bot 44 (2012): 165-170. Mohan, C. G., et al. "Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica." Asian Pacific journal of tropical medicine 6.4 (2013): 311-314. Baravalia, Yogesh, Yogeshkumar Vaghasiya, and Sumitra Chanda. "Brine shrimp cytotoxicity, anti-inflammatory and analgesic properties of Woodfordia fruticosa Kurz flowers." Iranian journal of pharmaceutical research: IJPR 11.3 (2012): 851. |
| 3 | Arthritis and rheumatism Activity | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Kayani, R. Rasheed, et al. "Medicinal plants and nonsteroidal anti-inflammatory drugs (NSAIDs) in treatment of arthritis: a literature review." Altern Therap Health Med 28 (2022): 58-64. Bhoria, Rajeev, et al. "Traditional medicinal aspects of some plants of Kinnaur and lahaul spiti tribal habitat of north west himalayan region of HP: a review." International Journal of Phytology Research 2.3 (2022): 19-23. Shaikh, A. M., et al. "Medicinal plants as potential source of anticancer agents: a review." Journal of Pharmacognosy and Phytochemistry 5.2 (2016): 291-295. Singh, Vibha. "Medicinal plants and bone healing." National journal of maxillofacial surgery 8.1 (2017): 4. Awan, Ashfaq Ahmed, et al. "Quantitative ethnobotany of medicinal plants uses in the Jhelum valley, Azad Kashmir, Pakistan." Acta Ecologica Sinica 41.2 (2021): 88-96. |
| 4 | Antioxidant Activity | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Shukla, Shipra, et al. "Comparative analysis of fatty acids and antioxidant activity of Betula utilis bark collected from different geographical region of India." Free Radicals and Antioxidants 7.1 (2017): 80-85. Singh, Saumya, et al. "A comparitive study of antioxidant properties and phytochemical composition of Trapa bispinosa, Trigonella foenum-graecum, Syzygium cumini and Betula utilis." Int J Pharm Sci Rev Res 38.2 (2016): 83-88. Vishwakarma, Rahul Kumar, Aaysha Negi, and Devendra Singh Negi. "Anti-oxidant, COX inhibition activity of different extract of bark of Betula utilis and molecular docking analysis of its phytochemicals against COX-1 and COX-2 isoenzyme." Materials Today: Proceedings 57 (2022): 251-258. Wani, Zishan Ahmad, and Shreekar Pant. "Betula utilis D. Don: an ecologically and economically important timberline species of himalayan region in jeopardy." The Botanical Review (2021): 1-15. Shah, Samir K., Kruti M. Patel, and Pinal M. Vaviya. "Evaluation of antiurolithiatic activity of Betula utilis in rats using ethylene glycol model." Asian Journal of Pharmaceutical Research 7.2 (2017): 81-87. Singh, Saumya, et al. "Betula utilis: A potential herbal medicine." Int J Pharm Biol Arch 3.3 (2012): 493-498. Ostapiuk, Aleksandra, et al. "Evaluation of antioxidative mechanisms in vitro and triterpenes composition of extracts from silver birch (Betula pendula roth) and black birch (Betula obscura kotula) barks by FT-IR and HPLC-PDA." Molecules 26.15 (2021): 4633. Radha, et al. "Evaluation of nutritional, phytochemical, and mineral composition of selected medicinal plants for therapeutic uses from cold desert of Western Himalaya." Plants 10.7 (2021): 1429. Kala, Chandra Prakash. "Uses, Population status and management of Betula utilis." Applied Ecology and Environmental Sciences 6.3 (2018): 79-83. Kumar, Mukul, et al. "Anti-obesity efficacy of the selected high altitude Himalayan herbs: In vitro studies." Journal of Food Science and Technology 57 (2020): 3081-3090. Ang, Aileen May Gabule, C. M. D. R. Nalda, and Sandra Espinosa Sabejon. "Brine shrimp lethality and antioxidant activity of the leaf, rind and seed ethanolic extracts of Durio zibethinus L." Asian J Biol Life Sci 7.3 (2018): 105. |
| 5 | Antimicrobial and antiviral Activity | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Biswasroy, Prativa, et al. "Phytochemical investigation, structural elucidation, in silico study and anti-psoriatic activity of potent bioactive from Betula utilis." Journal of Biomolecular Structure and Dynamics 41.17 (2023): 8093-8108. Pandey, Swapnil, et al. "Betula utilis extract prolongs life expectancy, protects against amyloid-β toxicity and reduces Alpha Synuclien in Caenorhabditis elegans via DAF-16 and SKN-1." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 228 (2020): 108647. Dhama, Kuldeep, et al. "Evidence based antibacterial potentials of medicinal plants and herbs countering bacterial pathogens especially in the era of emerging drug resistance: an integrated update." International Journal of Pharmacology 10.1 (2014): 1-43. Guo, Chang-An, et al. "An ethnobotany survey of wild plants used by the Tibetan people of the Yadong River Valley, Tibet, China." Journal of Ethnobiology and Ethnomedicine 18.1 (2022): 28. Dosoky, Noura S., Debra M. Moriarity, and William N. Setzer. "Phytochemical and biological investigations of Conradina canescens." Natural product communications 11.1 (2016): 1934578X1601100109. Weli, Afaf M., et al. "Cytotoxic and antimicrobial potential of different leaves extracts of R. fruticosus used traditionally to treat diabetes." Toxicology Reports 7 (2020): 183-187. Nistor, Madalina, et al. "Pentacyclic triterpenoid phytochemicals with anticancer activity: Updated studies on mechanisms and targeted delivery." International Journal of Molecular Sciences 24.16 (2023): 12923. Saleem, Mohammad, et al. "In vitro antibacterial activity and phytochemical analysis of hexane extract of Vicia sativa." ||| Bangladesh Journal of Pharmacology||| 9.2 (2014): 189-193. Raghuvanshi, Disha, et al. "Ethnomedicinal plants traditionally used for the treatment of jaundice (icterus) in Himachal Pradesh in Western Himalaya—a review." Plants 10.2 (2021): 232. Mithraja, Muraleedharannair Jalajakumari, et al. "Chemical diversity analysis on some selected medicinally important pteridophytes of Western Ghats, India." Asian Pacific Journal of Tropical Biomedicine 2.1 (2012): S34-S39. |
| 6 | Anti-Hyperglycaemic | Wani, Zishan Ahmad, and Shreekar Pant. "Betula utilis D. Don: an ecologically and economically important timberline species of himalayan region in jeopardy." The Botanical Review (2021): 1-15. Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Vishwakarma, Rahul Kumar, Aaysha Negi, and Devendra Singh Negi. "Anti-oxidant, COX inhibition activity of different extract of bark of Betula utilis and molecular docking analysis of its phytochemicals against COX-1 and COX-2 isoenzyme." Materials Today: Proceedings 57 (2022): 251-258. Mishra, Tripti, et al. "Phytochemical profiling of the stem bark of Betula utilis from different geographical regions of India using UHPLC‐ESI‐MS/MS." Analytical Science Advances 2.11-12 (2021): 497-504. Dhanik, Jyotsna, et al. "A brief review on some medicinal plants of Uttarakhand." Journal of Pharmacognosy and Phytochemistry 6.6 (2017): 2497-2506. Shaikh, A. M., et al. "Medicinal plants as potential source of anticancer agents: a review." Journal of Pharmacognosy and Phytochemistry 5.2 (2016): 291-295. Komal, Sharma, et al. "Berberis aristata: A review." Int J Res Ayurveda Pharm 2.2 (2011): 383-388. |
| 7 | Immunoregulatory Activity | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Polu, Picheswararao, Udupa Nayanabhirama, and Saleemulla Khan. "Herbal medicinal plants as an anticancer agents." Annals of Phytomedicine 4.1 (2015): 37-45. Aldahlawi, Alia M. "Modulation of dendritic cell immune functions by plant components." Journal of microscopy and ultrastructure 4.2 (2016): 55-62. Dhanik, Jyotsna, et al. "A brief review on some medicinal plants of Uttarakhand." Journal of Pharmacognosy and Phytochemistry 6.6 (2017): 2497-2506. Dhanik, Jyotsna, et al. "A brief review on some medicinal plants of Uttarakhand." Journal of Pharmacognosy and Phytochemistry 6.6 (2017): 2497-2506. Riekstina, Una, et al. "Effect of Betulin Colloidal Particles on Proliferation and Cytokine Secretion of Human Skin Fibroblasts." Plants 12.17 (2023): 3088. |
| 8 | Hepatoprotective Activity | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Duraiswamy, B., et al. "Hepatoprotective activity of Betula utilis bark on D-galactosamine induced hepatic insult." World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS) 1.1 (2012): 456-471. Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Mir, Naseer Ahmad, et al. "Ecology and Silviculture of Betula species in the Himalayan Region." (2016): 36-41. Vishwakarma, Rahul Kumar, Aaysha Negi, and Devendra Singh Negi. "Anti-oxidant, COX inhibition activity of different extract of bark of Betula utilis and molecular docking analysis of its phytochemicals against COX-1 and COX-2 isoenzyme." Materials Today: Proceedings 57 (2022): 251-258. SHARMA, PARUL, et al. "10. INDIAN HERBAL MEDICINE AS HEPATOPROTECTIVE AND HEPATOCURATIVEA-REVIEW OF SCIENTIFIC EVIDENCE By PARUL SHARMA2_ SAVITA RANI1_ SN OJHA1_ SK SOOD2 AND JC RANA1." Life Sciences Leaflets 50 (2014): 61 Mishra, Savita, Vidhu Aeri, and Deepshikha Pande Katare. "Hepatoprotective medication for liver injury." Journal of Pharmacy and Pharmaceutical Sciences 3 (2014): 891-932. Dhanik, Jyotsna, et al. "A brief review on some medicinal plants of Uttarakhand." Journal of Pharmacognosy and Phytochemistry 6.6 (2017): 2497-2506. Fahad, Shah, and Asghari Bano. "Ethnobotanical and physiological studies of some endangered plant species collected from two different altitudes in Gilgit Baltistan." Pak. J. Bot 44 (2012): 165-170. Saleem, Mohammad, et al. "Hepatoprotective effect of aqueous methanolic extract of Rumex dentatus in paracetamol-induced hepatotoxicity in mice." ||| Bangladesh Journal of Pharmacology||| 9.3 (2014): 284-289. |
| 9 | Gastroprotective Activity | Rastogi, Subha, Madan Mohan Pandey, and Ajay Kumar Singh Rawat. "Medicinal plants of the genus Betula—Traditional uses and a phytochemical–pharmacological review." Journal of ethnopharmacology 159 (2015): 62-83. Riekstina, Una, et al. "Effect of Betulin Colloidal Particles on Proliferation and Cytokine Secretion of Human Skin Fibroblasts." Plants 12.17 (2023): 3088. Arya, Vikrant, Ankur Bhardwaj, and Vinit Sharma. "Pharmacology of some antioxidant plants from district kangra himachal pradesh a review." International Journal of Current Pharmaceutical Research 3.2 (2011): 26-31. Priya, M. Devi. "A review on the pharmacology and phytochemistry of folklore medicinal plant Hyptis suaveolens (L.) Poit." International Journal of Basic, Applied and Innovative Research 4.4 (2015): 108-117. Mukherjee, Dhiman. "SWERTIA CHIRAYITA: ENDANGERED MEDICINAL HERB OF TEMPERATE HIMALAYA." Plant Stress Tolerance Physiological & Molecular Strategies (2016): 336. |
Market Overview
Global End Use Market
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Available Global Market
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Global Manufacturer Extract
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Distribution in IORA Countries
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Trade Data
Source Supply
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Trade Name
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Annual Consumption (in MT)
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PATENTS
| # | PATENT TITLE | PATENT/APPLICATION NO. | PATENT OFFICE | SOURCE |
|---|---|---|---|---|
| 1 | A PHARMACEUTICAL COMPOSITION COMPRISING PHYTOCHEMICALS ISOLATED FROM BETULA UTILIS FOR LUNG CANCER | 202411002900 | IPO | Details |
| 2 | HYPOALLERGENIC VARIANTS OF THE MAJOR ALLERGEN FROM BETULA VERRUCOSA POLLEN | 2017/KOLNP/2010 | IPO | Details |