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Plant Details

Aconitum heterophyllum

BOTANICAL DETAILS OF PLANT

Synonyms

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Classification

Kingdom

Plantae

Subkingdom

Superdivision

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Division

Streptophyta

Class

Equisetopsida

Subclass

Magnoliidae

Order

Ranunculales

Family

Ranunculaceae

Genus

Aconitum

Species

Aconitum heterophyllum

Plant Description

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Habit/Life Form

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DISTRIBUTION OF SPECIES IN INDIA

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Plant Parts Used

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System of Medicine

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Intended Use

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Traditional Application


Phytochemical Details

# Phytochemical Constituents PUBCHEM CID References
1 Atisine 6426913 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
2 Atidine 12299861 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
3 Hetisinone 101930090 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
4 Isoatisine 493986 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
5 Heteratisine 431671 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
6 Heterophylline 251575 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
7 Heterophyllidine 132491405 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
8 Heterophyllisine 101289617 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
9 Hetisine 431673 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.
10 Hetidine 101685340 Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.

Pharmacological Details

# PHARMACOLOGICAL ACTIONS/THERAPEUTIC USES REFERENCES
1 Antibacterial Activity

Ahmad, Manzoor, et al. "Norditerpenoid alkaloids from the roots of Aconitum heterophyllum Wall with antibacterial activity." Journal of Enzyme Inhibition and Medicinal Chemistry 23.6 (2008): 1018-1022.                                                    

Sinam, Yoirentomba Meetei, et al. "Antibacterial property of Aconitum heterophyllum root alkaloid." Int J Adv Res 2.7 (2014): 839-844.                   

 Prasad, Satyendra K., et al. "Antisecretory and antimotility activity of Aconitum heterophyllum and its significance in treatment of diarrhea." Indian Journal of Pharmacology 46.1 (2014): 82.                                                                                           

 Wani, Tareq A., Zahoor A. Kaloo, and Nisar A. Dangroo. "Aconitum heterophyllum Wall. ex Royle: A critically endangered medicinal herb with rich potential for use in medicine." Journal of Integrative Medicine 20.2 (2022): 104-113.                                                                                                                                

 Rasool, Mohammad Akhtar, et al. "Preparation, Characterisation and Antifungal activity of Gold Nanoparticles prepared with Fresh Extract of Aconitum heterophyllum leaves." Research Journal of Pharmacy and Technology 15.7 (2022): 3245-3250.  

Buddhadev, S. G., and S. S. Buddhadev. "A complete review on Ativisha-Aconitum heterophyllum." Pharm Sci Monit 8 (2017): 111-4.                           

 Mathew, Anna, et al. "Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties." Research Journal of Pharmacy and Technology 16.1 (2023): 470-476.                                                                     

 Kumar, Sanjay, et al. "In-vitro antifungal and anti-bacterial activity of chloroform extract from tubers of Aconitum laeve Royle: Endangered species, India." Materials Today: Proceedings 34 (2021): 563-568.                                                                                                                                        

Chandra, Sudeep, et al. "Climate change adversely affects the medicinal value of Aconitum species in Alpine region of Indian Himalaya." Industrial Crops and Products 186 (2022): 115277.                                             

Obaidullah, Muhammad Nisar Ahmad, Waqar Ahmad, and Shafiq Ahmad Tariq. "Najeeb ur Rahman, et al.(2018) Isolation and Characterization of C19-Diterpenoid Alkaloids from the Roots of Aconitum Heterophyllum Wall." J Med Chem Drug Designing 1: 101.                                                 

 Sinam, Yoirentomba Meetei, et al. "Isolation and identification of antibacterial compound from Indo–Himalayan Aconitum nagarum." Asian Pacific Journal of Tropical Disease 2 (2012): S878-S882.

2 Antiinflammatory Activity Verma, Santosh, Shreesh Ojha, and Mohammad Raish. "Anti-inflammatory activity of Aconitum heterophyllum on cotton pellet-induced granuloma in rats." J Med Plants Res 4.15 (2010): 1566-1569.                                       
Buddhadev, S. G., and S. S. Buddhadev. "A complete review on Ativisha-Aconitum heterophyllum." Pharm Sci Monit 8 (2017): 111-4.                       

Malhotra, Nikhil, and Shivani Sharma. "Aconitum heterophyllum." Himalayan medicinal plants. Academic Press, 2021. 5-25.                                                     

Aslam, Muhammad Shahzad, and Muhammad Syarhabil Ahmad. "Analgesic and antiinflammatory activity of genus Aconitum: A phytochemical and ethnopharmacological review." Recent Adv Biol Med 2.2016 (2016): 923.      

Ahmad, Manzoor, et al. "Norditerpenoid alkaloids from the roots of Aconitum heterophyllum Wall with antibacterial activity." Journal of Enzyme Inhibition and Medicinal Chemistry 23.6 (2008): 1018-1022.                          
 Mathew, Anna, et al. "Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties." Research Journal of Pharmacy and Technology 16.1 (2023): 470-476.                                                           
 Munir, Neelma, et al. "Evaluation of antifungal and antioxidant potential of two medicinal plants: Aconitum heterophyllum and Polygonum bistorta." Asian Pacific Journal of Tropical Biomedicine 4 (2014): S639-S643.   
          
Wani, Zishan A., and Shreekar Pant. "Aconitum heterophyllum Wall. ex Royle: An endemic, highly medicinal and critically endangered plant species of Northwestern Himalaya in Peril." Current Traditional Medicine 7.6 (2021): 2-7.   
                                                                                                                                
Ali, S., et al. "Assessment of threatened status, phytochemical composition and biological properties of three Aconitum species from Kashmir Himalaya-India." Curr Bot 12 (2021): 85-96.                                                               
Saravanan, Sujatha, Rajeswari Hari, and Karthikeyan Sekar. "Anti-proliferative potentials of Aconitum heterophyllum Root Extract in Human Breast cancer (MDA-MB-231) cell lines-Genetic and Antioxidant enzyme approach." Avicenna Journal of Medical Biotechnology 15.3 (2023): 188.                   

 Datey, Preeti, and Shailbala Baghel. "EXTRACTION, PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENTIAL OF HYDROALCOHOLIC EXTRACT OF ACONITUM HETEROPHYLLUM." Journal of Advanced Scientific Research 12.02 Suppl 2 (2021): 128-132.                                                                

  Nagarajan, M., et al. "Pharmacology of Ativisha, Musta and their substitutes." Journal of Ayurveda and integrative medicine 6.2 (2015): 121. 

 Obaidullah, Muhammad Nisar Ahmad, Waqar Ahmad, and Shafiq Ahmad Tariq. "Najeeb ur Rahman, et al.(2018) Isolation and Characterization of C19-Diterpenoid Alkaloids from the Roots of Aconitum Heterophyllum Wall." J Med Chem Drug Designing 1: 101.
3 Antioxident Activity

Prasad, Satyendra K., et al. "Physicochemical standardization and evaluation of in-vitro antioxidant activity of Aconitum heterophyllum Wall." Asian Pacific Journal of Tropical Biomedicine 2.2 (2012): S526-S531.       

Munir, Neelma, et al. "Evaluation of antifungal and antioxidant potential of two medicinal plants: Aconitum heterophyllum and Polygonum bistorta." Asian Pacific Journal of Tropical Biomedicine 4 (2014): S639-S643. 

Wani, Tareq A., Zahoor A. Kaloo, and Nisar A. Dangroo. "Aconitum heterophyllum Wall. ex Royle: A critically endangered medicinal herb with rich potential for use in medicine." Journal of Integrative Medicine 20.2 (2022): 104-113.    

Mathew, Anna, et al. "Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties." Research Journal of Pharmacy and Technology 16.1 (2023): 470-476.                                                           

Saravanan, Sujatha, Rajeswari Hari, and Karthikeyan Sekar. "Anti-proliferative potentials of Aconitum heterophyllum Root Extract in Human Breast cancer (MDA-MB-231) cell lines-Genetic and Antioxidant enzyme approach." Avicenna Journal of Medical Biotechnology 15.3 (2023): 188.          

Chandra, Sudeep, et al. "Climate change adversely affects the medicinal value of Aconitum species in Alpine region of Indian Himalaya." Industrial Crops and Products 186 (2022): 115277.                                                                    

Mehta, J. Y. O. T. I., and S. H. A. H. Shahista. "Studies on the screening of phytochemical, antioxidant and antibacterial activities of certain medicinal plants of Kashmir." International Journal of Biological Research and Development 9.2 (2021): 1-14.   

                                                                                   

Sekar, Karthikeyan, et al. "GC-MS Analysis and Antioxidant Evaluation of Ativisa Root Extract." Research Journal of Pharmacy and Technology 16.2 (2023): 703-708.                                                                                                                          

Prasad, Satyendra K., Alakh N. Sahu, and S. Hemalatha. "Cytomorphological and physicochemical evaluations of Cryptocoryne spiralis." Journal of herbs, spices & medicinal plants 18.4 (2012): 304-317.   

Sutan, Nicoleta Anca, et al. "Phytosynthesis of gold and silver nanoparticles enhance in vitro antioxidant and mitostimulatory activity of Aconitum toxicum Reichenb. rhizomes alcoholic extracts." Materials Science and Engineering: C 93 (2018): 746-758. 

4 Diuretics Activity Ukani, M. D., N. K. Mehta, and D. D. Nanavati. "Aconitum heterophyllum (ativisha) in ayurveda." Ancient Science of life 16.2 (1996): 166.                       

Rasve, Vishal R., et al. "Evaluation of Antiulcer activity of Aconitum heterophyllum on experimental animal." World J Pharm Pharm Sci 7.2 (2018): 819239.                                                                                                               
Ahmad, Khawaja Shafique, et al. "Conservation assessment and medicinal importance of some plants resources from Sharda, Neelum Valley, Azad Jammu and Kashmir, Pakistan." Int J Agric Biol 14.6 (2012): 997-1000.          

Chakrabarti, R. I. T. U. P. A. R. N. A., et al. "Screening of nine herbal plants for in vitro a-amylase inhibition." Screening 7.4 (2014): 84-89.                          

  Mehta, J. Y. O. T. I., and S. H. A. H. Shahista. "Studies on the screening of phytochemical, antioxidant and antibacterial activities of certain medicinal plants of Kashmir." International Journal of Biological Research and Development 9.2 (2021): 1-14.                                                                                   

 Nagarajan, M., et al. "Pharmacology of Ativisha, Musta and their substitutes." Journal of Ayurveda and integrative medicine 6.2 (2015): 121.  

Bisht, Akanksha, Vishal Kamboj, and Aditi Bisht. "Reviewing Medicinal Plants of Treasure Land: The Indian Himalayan Range." Environmental Pollution and Natural Resource Management. Cham: Springer International Publishing, 2022. 39-51.  
                                                                                                  
Verma, R. K., and V. P. Tewari. "Some important medicinal plants of cold desert regions of District Kinnaur of Himachal Pradesh state in India: Their uses and chemical ingredients." J. Plant Chemist Ecophysiol 1 (2016): 1009. 
5 Antidiarrheal Activity Prasad, Satyendra K., et al. "Antisecretory and antimotility activity of Aconitum heterophyllum and its significance in treatment of diarrhea." Indian Journal of Pharmacology 46.1 (2014): 82.                                                     
Paramanick, Debashish, et al. "Primary pharmacological and other important findings on the medicinal plant “Aconitum heterophyllum”(aruna)." Journal of Pharmacopuncture 20.2 (2017): 89.  

Malhotra, Nikhil, and Shivani Sharma. "Aconitum heterophyllum." Himalayan medicinal plants. Academic Press, 2021. 5-25.  Mathew, Anna, et al. "Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties." Research Journal of Pharmacy and Technology 16.1 (2023): 470-476.  
                                                                                                  
 Sinam, Yoirentomba Meetei, et al. "Antibacterial property of Aconitum heterophyllum root alkaloid." Int J Adv Res 2.7 (2014): 839-844.                       

  Wani, Zishan A., and Shreekar Pant. "Aconitum heterophyllum Wall. ex Royle: An endemic, highly medicinal and critically endangered plant species of Northwestern Himalaya in Peril." Current Traditional Medicine 7.6 (2021): 2-7. 
                                                                                                                        
Pande, N., et al. "The antidiarrheal and C19/C20 diterpenoid alkaloid constituents of high altitude Himalayan Aconitum heterophyllum." Planta Medica 80.10 (2014): PD77.                                                                                         
Nagarajan, M., et al. "Pharmacology of Ativisha, Musta and their substitutes." Journal of Ayurveda and integrative medicine 6.2 (2015): 121. 

Rajakrishnan, R., et al. "Therapeutic efficacy of the root tubers of Aconitum heterophyllum and its substitute Cyperus rotundus in the amelioration of pylorus ligation induced ulcerogenic and oxidative damage in rats." Saudi Journal of Biological Sciences 27.4 (2020): 1124-1129.
6 Nephroprotective Activity Paramanick, Debashish, et al. "Primary pharmacological and other important findings on the medicinal plant “Aconitum heterophyllum”(aruna)." Journal of Pharmacopuncture 20.2 (2017): 89.  

Konda, Venu Gopala Rao, et al. "Antioxidant and nephroprotective activities of aconitum heterophyllum root in glycerol induced acute renal failure in rats." Journal of clinical and diagnostic research: JCDR 10.3 (2016): FF01.                                                                                                                                              
Mathew, Anna, et al. "Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties." Research Journal of Pharmacy and Technology 16.1 (2023): 470-476.                                                       
 Kumar, Amandeep, and Pavithra Narendran. "Ethnomedicinal properties and conservation issues of an endangered medicinal plant-Aconitum heterophyllum Wall. ex Royle." Medicinal Plants-International Journal of Phytomedicines and Related Industries 14.3 (2022): 374-381. 
7 Antiproliferative Activity Saravanan, Sujatha, Rajeswari Hari, and Karthikeyan Sekar. "Anti-proliferative potentials of Aconitum heterophyllum Root Extract in Human Breast cancer (MDA-MB-231) cell lines-Genetic and Antioxidant enzyme approach." Avicenna Journal of Medical Biotechnology 15.3 (2023): 188.   

Munir, Neelma, et al. "Evaluation of antifungal and antioxidant potential of two medicinal plants: Aconitum heterophyllum and Polygonum bistorta." Asian Pacific Journal of Tropical Biomedicine 4 (2014): S639-S643.         
Parmar, Mayur P., et al. "Evaluation of antimitotic activity of herbal extracts using plant-based model systems and their cytotoxic potential against human colon carcinoma cells." Journal of Cancer Research and Therapeutics 17.6 (2021): 1483-1490.      
                                                                                                      
 Rafiq, Shah, et al. "Phytochemical screening, antioxidant and antifungal activities of Aconitum Chasmanthum Stapf ex Holmes wild rhizome extracts." Antioxidants 11.6 (2022): 1052.                                                                      
Tsering, Jambey, et al. "Traditional anti-poison plants used by the Monpa tribe of Arunachal Pradesh." Herbal insecticides, repellents and biomedicines: Effectiveness and commercialization (2016): 189-203.
8 Analgesic Activity  Buddhadev, S. G., and S. S. Buddhadev. "A complete review on Ativisha-Aconitum heterophyllum." Pharm Sci Monit 8 (2017): 111-4.                            

Prasad, Satyendra K., et al. "Physicochemical standardization and evaluation of in-vitro antioxidant activity of Aconitum heterophyllum Wall." Asian Pacific Journal of Tropical Biomedicine 2.2 (2012): S526-S531. 

 Wani, Tareq A., Zahoor A. Kaloo, and Nisar A. Dangroo. "Aconitum heterophyllum Wall. ex Royle: A critically endangered medicinal herb with rich potential for use in medicine." Journal of Integrative Medicine 20.2 (2022): 104-113.  
                                                                                                                            
 Nisar, Muhammad, et al. "New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors." Journal of Enzyme Inhibition and Medicinal Chemistry 24.1 (2009): 47-51.                           
Munir, Neelma, et al. "Evaluation of antifungal and antioxidant potential of two medicinal plants: Aconitum heterophyllum and Polygonum bistorta." Asian Pacific Journal of Tropical Biomedicine 4 (2014): S639-S643.                    

  Wani, Zishan A., and Shreekar Pant. "Aconitum heterophyllum Wall. ex Royle: An endemic, highly medicinal and critically endangered plant species of Northwestern Himalaya in Peril." Current Traditional Medicine 7.6 (2021): 2-7.  

Datey, Preeti, and Shailbala Baghel. "EXTRACTION, PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENTIAL OF HYDROALCOHOLIC EXTRACT OF ACONITUM HETEROPHYLLUM." Journal of Advanced Scientific Research 12.02 Suppl 2 (2021): 128-132.                  

Obaidullah, Muhammad Nisar Ahmad, Waqar Ahmad, and Shafiq Ahmad Tariq. "Najeeb ur Rahman, et al.(2018) Isolation and Characterization of C19-Diterpenoid Alkaloids from the Roots of Aconitum Heterophyllum Wall." J Med Chem Drug Designing 1: 101.
                                                                            
Thabrew, M. Ira, M. G. Dharmasiri, and L. Senaratne. "Anti-inflammatory and analgesic activity in the polyherbal formulation Maharasnadhi Quathar." Journal of ethnopharmacology 85.2-3 (2003): 261-267.                       
Ali, Sabeena, et al. "A comprehensive review of phytochemistry, pharmacology and toxicology of the genus Aconitum L." Advances in Traditional Medicine (2021): 1-22. 
                                                                    
Sasidharan, Shan, et al. "Pharmacological Evaluation of the Anesthetic and Analgesic Potential of Injection Harsha 22: A Novel Polyherbal Local Anesthetic Formulation Intended for Parenteral Administration in Wistar Albino Rats." Journal of Experimental Pharmacology (2023): 149-161.
9 Antiulcer Activity Rasve, Vishal R., et al. "Evaluation of Antiulcer activity of Aconitum heterophyllum on experimental animal." World J Pharm Pharm Sci 7.2 (2018): 819239.                                                                                                                      
Mathew, Anna, et al. "Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties." Research Journal of Pharmacy and Technology 16.1 (2023): 470-476.                                                         
 Munir, Neelma, et al. "Evaluation of antifungal and antioxidant potential of two medicinal plants: Aconitum heterophyllum and Polygonum bistorta." Asian Pacific Journal of Tropical Biomedicine 4 (2014): S639-S643.                    

Wani, Zishan A., and Shreekar Pant. "Aconitum heterophyllum Wall. ex Royle: An endemic, highly medicinal and critically endangered plant species of Northwestern Himalaya in Peril." Current Traditional Medicine 7.6 (2021): 2-7. 
10 Gastroprotective Activity Rajakrishnan, R., et al. "Therapeutic efficacy of the root tubers of Aconitum heterophyllum and its substitute Cyperus rotundus in the amelioration of pylorus ligation induced ulcerogenic and oxidative damage in rats." Saudi Journal of Biological Sciences 27.4 (2020): 1124-1129.                                    

 Sajad, Mohd, and Sonu Chand Thakur. "Traditional Uses and Anti-Inflammatory Activities of Different Medicinal Plants: A Systematic Review." Int. J. Ayurvedic Herb. Med 9 (2018): 3410-3432.
                               
Georgiev, Yordan Nikolaev, and Manol Hristov Ognyanov. "and Petko Nedyalkov DenevⓇ D." Recent Contributions to Bioinformatics and Biomedical Sciences and Engineering 658 (2023): 167.                                  
 Kumar, T., Dileep Kumar, and Rohit Sharma. "Shwasananda Vati, a South Indian Traditional Herbo-Mineral Formulation: Insights on the Proposed Biological Roles, Safety, and Therapeutic Profile." Current Traditional Medicine 9.3 (2023): 13-27. 
                                                                                             
Swain, Ayusman. "Antidiabetic Properties of Natural Products of Cyperus Species Plants: A Review." Ind. J. Pharm. Edu. Res 57.2s (2023): s226-s233. 
11 Antiobesity Activity KUMAR, JAIN SURENDRA, JAIN RUCHI, and JAIN NILESH. "Antiobesity potential of Aconitum Heterophyllum roots." Int J Pharma Bio Sci 10.3 (2019): 65-74.                                                                                                                            
 Mathew, Anna, et al. "Therapeutic Potential of Aconitum heterophyllum: A Review on Phyto-pharmacological properties." Research Journal of Pharmacy and Technology 16.1 (2023): 470-476.                                                      
Kumar, Mukul, et al. "Anti-obesity efficacy of the selected high altitude Himalayan herbs: In vitro studies." Journal of Food Science and Technology 57 (2020): 3081-3090.                                                                                                             
Prajapati, Vishal Nandlal, and V. K. Kori. "Comparative Clinical Efficacy of Vachadi Vati and Triphalaguduchyadi Vati with Diet and Lifestyle Modification in the Management of Overweight Children." Journal of Ayurveda 17.2 (2023): 94-103. 
                                                                                        
Valsaraj, Megha, et al. "Anti-Obesity Molecules from Plants and their Mode of Action." Anti-obesity Drug Discovery and Development 4 (2018): 197. 

 Panigrahi, Tapas, Suraj Vishwas, and Deepak Dash. "A herbal approach to obesity Management: a review." Asian J Pharmaceut Educ Res 6 (2017): 1-5
12 Anticonvulasant Activity Nyirimigabo, Eric, et al. "A review on phytochemistry, pharmacology and toxicology studies of Aconitum." Journal of Pharmacy and Pharmacology 67.1 (2015): 1-19.                                                                                                                      
Ali, Sabeena, et al. "A comprehensive review of phytochemistry, pharmacology and toxicology of the genus Aconitum L." Advances in Traditional Medicine (2021): 1-22.                                                                                   
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 Kumari, Nidhi, et al. "An outline on vasicine, its ethnomedical and nanoformulation approach." Journal of Biologically Active Products from Nature 11.1 (2021): 42-59.                                                                                               
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Market Overview

Global End Use Market

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Available Global Market

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Global Manufacturer Extract

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Distribution in IORA Countries

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Trade Data

Source Supply

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Annual Consumption (in MT)

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Adulterant/Substitute

CULTIVARS AND VARIETIES