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Cardiospermum halicacabum L
BOTANICAL DETAILS OF PLANT
Synonyms
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Classification
Kingdom
Plantae
Subkingdom
Superdivision
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Division
Spermatophyta
Class
Dicotyledonae
Subclass
Order
Sapindales
Family
Sapindaceae
Genus
Cardiospermum
Species
Cardiospermum halicacabum
Plant Description
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Habit/Life Form
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DISTRIBUTION OF SPECIES IN INDIA
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Plant Parts Used
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System of Medicine
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Intended Use
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Traditional Application
Phytochemical Details
| # | Phytochemical Constituents | PUBCHEM CID | References |
|---|---|---|---|
| 1 | Coniferaldehyde | 5280536 | Elangovan, Abbirami, et al. |
| 2 | Coumaroylquinic Acid | 6441280 | Elangovan, Abbirami, et al. "Ethnomedical, phytochemical and pharmacological insights on an Indian medicinal plant: The balloon vine (Cardiospermum halicacabum Linn.)." Journal of Ethnopharmacology 291 (2022): 115143. |
| 3 | Ferulic Acid | 445858 | Elangovan, Abbirami, et al. "Ethnomedical, phytochemical and pharmacological insights on an Indian medicinal plant: The balloon vine (Cardiospermum halicacabum Linn.)." Journal of Ethnopharmacology 291 (2022): 115143. |
| 4 | Prunin | 92794 | Elangovan, Abbirami, et al. |
| 5 | Phloridzin | 6072 | Elangovan, Abbirami, et al. |
| 6 | Methyl Salvianolate | 46917416 | Elangovan, Abbirami, et al. |
| 7 | Caftaric Acid | 6440397 | Elangovan, Abbirami, et al. |
| 8 | Indole-3-Carboxylic Acid | 69867 | Elangovan, Abbirami, et al. |
| 9 | 4-Hydroxybenzoic Acid | 135 | Elangovan, Abbirami, et al. |
| 10 | P-Coumaric Acid | 637542 | Elangovan, Abbirami, et al. |
| 11 | Methyl 3,4-Dihydroxybenzoate | 287064 | Elangovan, Abbirami, et al. |
| 12 | Chrysoeriol | 5280666 | Elangovan, Abbirami, et al. |
| 13 | Protocatechuic Acid | 72 | Elangovan, Abbirami, et al. |
| 14 | Cardiospermin | 179647 | Elangovan, Abbirami, et al. |
| 15 | Methyl 4, 4-dimethoxy-3- butyrate | 129724773 | Elangovan, Abbirami, et al. |
| 16 | Cyclopentanamine | 2906 | Elangovan, Abbirami, et al. |
| 17 | Neophytadiene | 10446 | Elangovan, Abbirami, et al. |
Pharmacological Details
| # | PHARMACOLOGICAL ACTIONS/THERAPEUTIC USES | REFERENCES |
|---|---|---|
| 1 | Antifungal Activity | Gaziano, Roberta, et al. "Antifungal activity of Cardiospermum halicacabum L.(Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90." Drug design, development and therapy (2018): 2185-2193. Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Kamalakannan, K., et al. "A Study on phytochemical and antimicrobial activity of Cardiospermum halicacabum L." IEEE-International Conference On Advances In Engineering, Science And Management (ICAESM-2012). IEEE, 2012. Sayanam, Rajeswari Ranga Anantha, et al. "Antibacterial, antifungal, and antioxidant competence of Cardiospermum halicacabum based nanoemulsion and characterized their physicochemical properties." 3 Biotech 13.8 (2023): 284. Julian, Jemina D. "In vivo and in vitro Colletotrichum fruit rot inhibiting Activity of Parol-Parolan (Cardiospermum halicacabum L.) Leaves and Stem Extract on Post-Harvest Eggplant (Solanum melongena)."(2019). Philippine Journal of Natural and Social Sciences 3.1. |
| 2 | Anti-Inflammatory Activity | Huang, Ming-Hsing, et al. "Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo." Journal of ethnopharmacology 133.2 (2011): 743-750. Sadique, J., et al. "Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation." Journal of ethnopharmacology 19.2 (1987): 201-212. Babu, KC Venkatesh, and S. Krishnakumari. "Anti-inflammatory and antioxidant compound, rutin in Cardiospermum halicacabum leaves." Ancient science of life 25.2 (2005): 47. Sheeba, M. S., and V. V. Asha. "Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-α and iNOS expression, which is mediated by NF-κB regulation, in RAW264. 7 cells." Journal of ethnopharmacology 124.1 (2009): 39-44. Sheeba, M. S., and V. V. Asha. "Effect of Cardiospermum halicacabum on ethanol-induced gastric ulcers in rats." Journal of ethnopharmacology 106.1 (2006): 105-110. Fai, Dario, et al. "Cardiospermum halicacabum in atopic dermatitis: Clinical evidence based on phytotherapic approach." Dermatologic Therapy 33.6 (2020): e14519. Balamurugan, V., and L. Muruganandam. "In-vitro Anti-Inflammatory and Anti-Arthritic Activity of Cardiospermum Halicacabum and Moringa Oleifera Leaves Extract." Journal of Advanced Scientific Research 12.01 Suppl 2 (2021): 78-82. Bampali, E., and R. Bauer. "Investigations on the anti-inflammatory activity of Cardiospermum halicacabum." Planta Medica 87.15 (2021): 1291-1291. Jeyadevi, R., et al. "Chemical constituents and antimicrobial activity of Indian green leafy vegetable Cardiospermum halicacabum." Indian journal of microbiology 53 (2013): 208-213. Padmini, Nandhini, et al. "In vitro and in vivo anti-arthritic activity of combined ethanolic extracts of Pisonia grandis and Cardiospermum halicacabum in Wistar rats." Journal of Applied Pharmaceutical Science 6.9 (2016): 102-108. Murti, Krishna, et al. "Pharmacological Properties of Cardiospermum halicacabum-A Review." Sect. Title Pharmacol 5 (2010): 1005-1009. Zalke, Ashish S., et al. "Pharmacognostical evaluation of Cardiospermum halicacabum Linn. leaf and stem." Ancient science of life 33.1 (2013): 15. Arjumand, Ara, K. S. Reddy, and C. S. Reddy. "Analgesic anti-pyretic and anti-inflammatory activity of various extracts of stem of Cardiospermum halicacabum." Journal of Chemical and Pharmaceutical Sciences 2.1 (2009): 20-25. |
| 3 | Adulticidal Activity | Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Govindarajan, M., et al. "Adulticidal activity of Pithecellobium dulce (Roxb.) Benth. against Culex quinquefasciatus (Say)." Asian Pacific Journal of Tropical Disease 2.2 (2012): 124-128. Govindarajan, Marimuthu, and Rajamohan Sivakumar. "Ovicidal, larvicidal and adulticidal properties of Asparagus racemosus (Willd.)(Family: Asparagaceae) root extracts against filariasis (Culex quinquefasciatus), dengue (Aedes aegypti) and malaria (Anopheles stephensi) vector mosquitoes (Diptera: Culicidae)." Parasitology research 113 (2014): 1435-1449. Maheswaran, Rajan, and Savarimuthu Ignacimuthu. "Effect of Polygonum hydropiper L. against dengue vector mosquito Aedes albopictus L." Parasitology research 113 (2014): 3143-3150. Panneerselvam, Chellasamy, and Kadarkarai Murugan. "Adulticidal, repellent, and ovicidal properties of indigenous plant extracts against the malarial vector, Anopheles stephensi (Diptera: Culicidae)." Parasitology research 112 (2013): 679-692. Gaur, R. L., et al. "Antifilarial activity of Caesalpinia bonducella against experimental filarial infections." Indian Journal of Medical Research 128.1 (2008): 65-70. Ramkumar, Govindaraju, et al. "Insecticidal and repellent activity of Clausena dentata (Rutaceae) plant extracts against Aedes aegypti and Culex quinquefasciatus mosquitoes (Diptera: Culicidae)." Parasitology research 114 (2015): 1139-1144. Fernandes, Diégina Araújo, et al. "Ovicidal, pupicidal, adulticidal, and repellent activity of Helicteres velutina K. Schum against Aedes aegypti L.(Diptera: Culicidae)."2021). Brazilian Journal of Veterinary Medicine 43. Veerakumar, Kaliyan, Marimuthu Govindarajan, and S. L. Hoti. "Evaluation of plant-mediated synthesized silver nanoparticles against vector mosquitoes." Parasitology research 113 (2014): 4567-4577. Silvério, Maíra Rosato Silveiral, et al. "Plant natural products for the control of Aedes aegypti: The main vector of important arboviruses." Molecules 25.15 (2020): 3484. Govindarajan, Marimuthu, and Rajamohan Sivakumar. "Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae)." Parasitology research 110 (2012): 1607-1620. Amerasan, D., et al. "Bioefficacy of Morinda tinctoria and Pongamia glabra plant extracts against the malaria vector Anopheles stephensi (Diptera: Culicidae)." Journal of Entomological and Acarological Research 47.1 (2015): 31-40. |
| 4 | Anxiolytic Activity | Kumar, Rajesh, et al. "Isolation of anxiolytic principle from ethanolic root extract of Cardiospermum halicacabum." Phytomedicine 18.2-3 (2011): 219-223. Malaviya, Shailesh, et al. "Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice." Internet J Pharmacol 7.1 (2009): 1-6. Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Mahmood, Raana, et al. "Evaluation of neuropharmacological activity of Cardiospermum halicacabum (Linn) leaf extract." World J. Pharm. Pharm. Sci 5.3 (2015): 896-906. Sharma, Amit S., and Satish A. Bhalerao. "Review of Ethnobotanical, Phytochemical and Pharmacological Profile of Cardio-spermum Halicacabum Linn." International Journal of Pharmaceutics and Drug Analysis 6.3 (2018): 371-376. Akbar, Shahid, and Shahid Akbar. "Cardiospermum halicacabum L.(Sapindaceae)." Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications (2020): 507-514. Jeyadevi, Ramachandran, et al. "Anti-arthritic activity of the Indian leafy vegetable Cardiospermum halicacabum in Wistar rats and UPLC–QTOF–MS/MS identification of the putative active phenolic components." Inflammation Research 62 (2013): 115-126. Ferrara, Lydia. "Cardiospermum halicacabum Linn.: Food and Drug." International Journal of Medical Reviews 5.4 (2018): 146-150. Aishwarya, V., et al. "In vitro antioxidant and anticancer activity of Cardiospermum halicacabum L. against EAC cell line." Int J Pharm Pharm Sci 6.8 (2014): 263-8. Rajeswari, R., and M. Sriidevi. "Isolation of active compounds from hydro alcoholic extract of cardiospermum Halicacabum Linn." International Journal of Pharmaceutical Sciences and Research 5.11 (2014): 4832. |
| 5 | Antidiarrheal Activity | Rao, N. Venkat, K. Chandra Prakash, and SM Shanta Kumar. "Pharmacological investigation of Cardiospermum halicacabum (Linn) in different animal models of diarrhoea." Indian Journal of Pharmacology 38.5 (2006): 346. Murti, Krishna, et al. "Pharmacological Properties of Cardiospermum halicacabum-A Review." Sect. Title Pharmacol 5 (2010): 1005-1009. Sarvanandaa, L., Amal D. Premarathna, and S. C. Karunarathnad. "Immunomodulatory effect of Cardiospermum halicacabum against cancer." Biomedical Journal 1.4 (2018): 97-109. Sharma, Amit S., and Satish A. Bhalerao. "Review of Ethnobotanical, Phytochemical and Pharmacological Profile of Cardio-spermum Halicacabum Linn." International Journal of Pharmaceutics and Drug Analysis 6.3 (2018): 371-376. Rajeswari, R., and M. Sriidevi. "Isolation of active compounds from hydro alcoholic extract of cardiospermum Halicacabum Linn." International Journal of Pharmaceutical Sciences and Research 5.11 (2014): 4832. |
| 6 | Antipyretic Activity | Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Sheeba, M. S., and V. V. Asha. "Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-α and iNOS expression, which is mediated by NF-κB regulation, in RAW264. 7 cells." Journal of ethnopharmacology 124.1 (2009): 39-44. Sheeba, M. S., and V. V. Asha. "Effect of Cardiospermum halicacabum on ethanol-induced gastric ulcers in rats." Journal of ethnopharmacology 106.1 (2006): 105-110. Murugan, Kasi, et al. "Antiviral activity of Cardiospermum halicacabum L. extract against coinfecting agents HIV and HBV." Journal of herbs, spices & medicinal plants 17.4 (2011): 403-418. Veerappan, Loganathan, and N. Pradheepa. "EVALUATION OF ANTIMICROBIAL POTENTIALS OF Cardiospermum halicacabum Linn." Indonesian Journal of Pharmacy 24.1 (2013): 61-64. Veeramani, Chinnadurai, et al. "Influence of Cardiospermum halicacabum leaf extract on membrane-bound ATPases in streptozotocin-induced diabetic rats." African Journal of Traditional, Complementary and Alternative Medicines 12.3 (2015): 68-74. Jeyadevi, R., et al. "Phenolic profiling by UPLC–MS/MS and hepatoprotective activity of Cardiospermum halicacabum against CCl4 induced liver injury in Wistar rats." Journal of Functional Foods 5.1 (2013): 289-298. Veeramani, Chinnadurai, et al. "Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ–induced hyperglycemic rats." Asian Pacific Journal of Tropical Medicine 5.12 (2012): 939-944. Shekhawat, M. S., et al. "In vitro clonal propagation of Cardiospermum halicacabum L. through nodal segment cultures." The Pharma Innovation 1.7, Part A (2012): 1. |
| 7 | Antifilarial Activity | Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Gaziano, Roberta, et al. "Antifungal activity of Cardiospermum halicacabum L.(Sapindaceae) against Trichophyton rubrum occurs through molecular interaction with fungal Hsp90." Drug design, development and therapy (2018): 2185-2193. Gaur, R. L., et al. "Antifilarial activity of Caesalpinia bonducella against experimental filarial infections." Indian Journal of Medical Research 128.1 (2008): 65-70. Sahare, K. N., et al. "Antifilarial Potential of Butea monosperma L. against microfilaria in vitro." International Journal of PharmTech Research 4.3 (2012): 1181-1184. Balamurugan, V., and L. Muruganandam. "In-vitro Anti-Inflammatory and Anti-Arthritic Activity of Cardiospermum Halicacabum and Moringa Oleifera Leaves Extract." Journal of Advanced Scientific Research 12.01 Suppl 2 (2021): 78-82. |
| 8 | Antiulcer Activity | Karuppannan, Sathish Kumar, et al. "Phytochemical and antibacterial activity of Cardiospermum halicacabum against wound pathogens." (2020). Pharmacognosy Journal 12.6. Jeyadevi, R., et al. "Chemical constituents and antimicrobial activity of Indian green leafy vegetable Cardiospermum halicacabum." Indian journal of microbiology 53 (2013): 208-213. Ferrara, Lydia. "Cardiospermum halicacabum Linn.: Food and Drug." International Journal of Medical Reviews 5.4 (2018): 146-150. Zalke, Ashish S., et al. "Pharmacognostical evaluation of Cardiospermum halicacabum Linn. leaf and stem." Ancient science of life 33.1 (2013): 15. Veeramani, Chinnadurai, et al. "Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ–induced hyperglycemic rats." Asian Pacific Journal of Tropical Medicine 5.12 (2012): 939-944. Jayanthi, G., et al. "BIOCHEMICAL STUDIES ON THE ANTI-ULCEROGENIC POTENTIAL OF CARDIOSPERMUM HALICACABUM L. SEEDS." International Journal of Pharmaceutical Sciences and Research 3.12 (2012): 5037. Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Velmurugan, V., et al. "Evaluation of Diuretic Activity on Leaves Extract of Cardiospermum halicacabum Linn." Research Journal of Pharmacy and Technology 12.4 (2019): 1607-1609. |
| 9 | Antimalarial Activity | Waako, P. J., et al. "The in vitro and in vivo antimalarial activity of Cardiospermum halicacabum L. and Momordica foetida Schumch. Et Thonn." Journal of Ethnopharmacology 99.1 (2005): 137-143. Murti, Krishna, et al. "Pharmacological Properties of Cardiospermum halicacabum-A Review." Sect. Title Pharmacol 5 (2010): 1005-1009. Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Zalke, Ashish S., et al. "Pharmacognostical evaluation of Cardiospermum halicacabum Linn. leaf and stem." Ancient science of life 33.1 (2013): 15. Malaviya, Shailesh, et al. "Anxiolytic activity of root extracts of Cardiospermum halicacabum in mice." Internet J Pharmacol 7.1 (2009): 1-6. Balamurugan, V., and L. Muruganandam. "In-vitro Anti-Inflammatory and Anti-Arthritic Activity of Cardiospermum Halicacabum and Moringa Oleifera Leaves Extract." Journal of Advanced Scientific Research 12.01 Suppl 2 (2021): 78-82. |
| 10 | Anticonvulsant Activity | Dhayabaran, Daniel, Jeyaseeli Florance, and Nandakumar Krsihnadas. "Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum." Revista Brasileira de Farmacognosia 22 (2012): 323-329. Ferrara, Lydia. "Cardiospermum halicacabum Linn.: Food and Drug." International Journal of Medical Reviews 5.4 (2018): 146-150. Thabrew, Ira, et al. "The effects of Cassia auriculata and Cardiospermum halicacabum teas on the steady state blood level and toxicity of carbamazepine." Journal of ethnopharmacology 90.1 (2004): 145-150. Vetrichelvan, T., and M. Jegadeesan. "Evaluation of analgesic, anticonvulsant locomotor activities of alcoholic extract achyranthes bidentata blume in mice." Ancient science of life 22.1 (2002): 17. Srinivasan, Rajendran, et al. "In vitro antimicrobial activity of Caesalpinia sappan L." Asian Pacific Journal of Tropical Biomedicine 2.1 (2012): S136-S139. Asadi‐Pooya, Ali A., et al. "Caffeinated drinks, fruit juices, and epilepsy: A systematic review." Acta Neurologica Scandinavica 145.2 (2022): 127-138. |
| 11 | Anti-Cancer Activity | Kumar, S. Mathan, V. Jiju, and D. Chamundeeswari. "Investigation of phytoconstituents of Cardiospermum halicacabum and its efficacy as a potential anti-cancer drug candidate." Journal of Drug Delivery and Therapeutics 9.4-s (2019): 252-257. Arunkumar, S., et al. "Preliminary phytochemical analysis, HPTLC finger printing and in vitro anticancer screening of extracts of aerial parts of Cardiospermum halicacabum." International Journal of Pharmacy and Pharmaceutical Sciences 5.3 (2013): 301-304. Sagadevan, P., et al. "Anticancer activity of methanolic leaf extracts of Andrographis paniculata (Nees) and Cardiospermum halicacabum (Linn) against human breast cancer cell line (MCF-7)." Int. J. of Pharm. & Life Sci.(IJPLS) 4.9 (2013): 2983-2986. Ganesan, Krishnamoorthy, et al. "Protective effect of Withania somnifera and Cardiospermum halicacabum extracts against collagenolytic degradation of collagen." Applied biochemistry and biotechnology 165 (2011): 1075-1091. Rameshwari, K. Sudha, M. Abirami, and R. Christobel. "Partial Characterization of green synthesized silver nanoparticles of Cardiospermum halicacabum and Butea monosperma aqueous extract combination (CHBMCSNP)." Research Journal of Pharmacy and Technology 13.12 (2020): 6218-6223. Babu, K. Sudhakar, et al. "Pharmacological And Phytochemical Study of Cardiospermum Helicacabum Linn Medicinal Plant." Journal of Applicable Chemistry 3.3 (2014): 1224-1231. Arun Raj, G. R., et al. "Review on the contribution of Dashapushpa, a traditional medicine in the management of cancer." Global J Res. Med. Plants & Indigen. Med 2.9 (2013): 656-663. Mary, J. Violet, C. Pragathiswaran, and N. Anusuya. "Photocatalytic, degradation, sensing of Pb2+ using titanium nanoparticles synthesized via plant extract of Cissusquadrangularis: In-vitroanalysis of microbial and anti-cancer activities." Journal of Molecular Structure 1236 (2021): 130144. |
| 12 | Analgesic Activity | Sheeba, M. S., and V. V. Asha. "Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-α and iNOS expression, which is mediated by NF-κB regulation, in RAW264. 7 cells." Journal of ethnopharmacology 124.1 (2009): 39-44. Muthumani, P., et al. "Study of phyto chemical, analgesic and anti ulcer activity of extracts of aerial parts of Cardiospermum halicacabum Linn." International Journal of Pharmaceutical Sciences and Research 1.10 (2010): 128. Sheeba, M. S., and V. V. Asha. "Effect of Cardiospermum halicacabum on ethanol-induced gastric ulcers in rats." Journal of ethnopharmacology 106.1 (2006): 105-110. Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Sughuna, K., and P. Brindha. "Antibacterial and Analgesic activity of a Siddha drug–“Mudakatton”." Journal of Pharmacy Research 4.1 (2011): 83-84. Elangovan, Abbirami, et al. "Ethnomedical, phytochemical and pharmacological insights on an Indian medicinal plant: The balloon vine (Cardiospermum halicacabum Linn.)." Journal of Ethnopharmacology 291 (2022): 115143. Jeyadevi, R., et al. "Chemical constituents and antimicrobial activity of Indian green leafy vegetable Cardiospermum halicacabum." Indian journal of microbiology 53 (2013): 208-213. Kumaran, A., and R. Joel Karunakaran. "Antioxidant Activities of the Methanol Extract of Cardiospermum halicacabum." Pharmaceutical biology 44.2 (2006): 146-151. |
| 13 | Cardioprotective Activity | Rajasekaran, A., R. Arivukkarasu, and G. Venkatesh. "Balloon Vine (Cardiospermum halicacabum L.) and Cardiovascular Protection: Cellular, Molecular and Metabolic Aspects." Ancient and Traditional Foods, Plants, Herbs and Spices used in Cardiovascular Health and Disease: 125-144. Elangovan, Abbirami, et al. "Ethnomedical, phytochemical and pharmacological insights on an Indian medicinal plant: The balloon vine (Cardiospermum halicacabum Linn.)." Journal of Ethnopharmacology 291 (2022): 115143. Maulik, Subir K., and Sanjay K. Banerjee. "Uses of herbals in cardiac diseases: priority of evidence over belief." Evidence-Based Validation of Herbal Medicine. Elsevier, 2015. 515-529. Dar, Nawab John, Abid Hamid, and Muzamil Ahmad. "Pharmacologic overview of Withania somnifera, the Indian Ginseng." Cellular and molecular life sciences 72 (2015): 4445-4460. Adewoyin, Malik, et al. "Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress." Diseases 5.1 (2017): 9. Yadav, Sheetal, et al. "Terminalia arjuna (Arjun Tree): A Sacred plant with high medicinal and therapeutic potential." Research Journal of Pharmacy and Technology 15.12 (2022): 5859-5867. D Doss, Victor Arokia, and K. U. B. E. R. A. P. A. N. D. I. A. N. Dharaniyambigai. "Effect of hydroethanolic extract of Piper betle in isoproterenol induced cardiac hypertrophy." INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES 10.4 (2019): 3055-3062. |
| 14 | Anti-Arthritic Activity | Jeyadevi, Ramachandran, et al. "Anti-arthritic activity of the Indian leafy vegetable Cardiospermum halicacabum in Wistar rats and UPLC–QTOF–MS/MS identification of the putative active phenolic components." Inflammation Research 62 (2013): 115-126. Padmini, Nandhini, et al. "In vitro and in vivo anti-arthritic activity of combined ethanolic extracts of Pisonia grandis and Cardiospermum halicacabum in Wistar rats." Journal of Applied Pharmaceutical Science 6.9 (2016): 102-108. Kumar, Eswar, et al. "Anti-Arthritic Property of the Ethanolic Leaf Extract of Cardiospermum Halicacabum Linn." Biomedical and Pharmacology Journal 1.2 (2015): 395-400. Aiyalu, Rajasekaran, et al. "Evaluation of Synergistic Effect of Methanol Leaf Extract of Cardiospermum halicacabum and Vitex negundo on Inflammation and Arthritis." Journal of Herbs, Spices & Medicinal Plants 20.4 (2014): 372-385. Sarvanandaa, L., Amal D. Premarathna, and S. C. Karunarathnad. "Immunomodulatory effect of Cardiospermum halicacabum against cancer." Biomedical Journal 1.4 (2018): 97-109. Kamble, A. B., et al. "Hemato-biochemical changes due to ethanolic extract of Cardiospermum halicacabum in arthritic rats." Environment and Ecology 35.2D (2017): 1571-1574. Pushpan, Reshmi, K. Nishteswar, and Harshitha Kumari. "Anti-arthritic natural medicine: Classical Ayurvedic and ethnomedical source." ASL Muscuskel Dis 1 (2013): 32-40. Arthia, R., et al. "Anti-arthritic effect of leafs of Cardiospermum halicacabum juice in patients with rheumatoid arthritis–a case report." PharmaNutrition 10 (2019): 100170. Shekhawat, Mahipal S., et al. "Synthesis of silver nanoparticles using Cardiospermum halicacabum L. leaf extract and their characterization." J Phytopharmacol 2.5 (2013): 15-20. Thirumalai, V., P. Nirmala, and R. Venkatanarayanan. "In vitro Anti-arthritic activity of Methanolic leaf extract of Cadaba indica Lam." Research Journal of Pharmacy and Technology 13.3 (2020): 1219-1223. |
| 15 | Anti-Diabetic Activity | Sarvanandaa, L., Amal D. Premarathna, and S. C. Karunarathnad. "Immunomodulatory effect of Cardiospermum halicacabum against cancer." Biomedical Journal 1.4 (2018): 97-109. Jenny, S., and P. Baskar. "ASSESSMENT OF PHYTOCONSTITUENTS AND ANTIMICROBIAL ACTIVITY OF CARDIOSPERMUM HALICACABUM L." Journal of Advanced Scientific Research 10.03 Suppl 1 (2019): 218-221. Aljarah, Ali Kadhim, and Imad Hadi Hameed. "In vitro anti-diabetic properties of Methanolic extract of Thymus vulgaris using α-glucosidase and α-amylase inhibition assay and determination of its bioactive chemical compounds." Indian Journal of Public Health Research and Development 9.3 (2018): 388-392. Krishnan, Baskaran, et al. "Chrysoeriol ameliorates hyperglycemia by regulating the carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats." Food Science and Human Wellness 9.4 (2020): 346-354. Mannan, A., et al. "A quick review on anti-diabetic plants and action of phytochemicals." Inter J Adv Res 2 (2014): 227. Merish, S., et al. "Evaluation of in-vitro Anti Diabetic Activity of a Siddha Herbo-Mineral Drug." Current Traditional Medicine 1.2 (2015): 84-90. Mendam, Kishore, B. Kavitha, and S. Jithender Kumar Naik. "Natural sources used for treatment and prevention of filariasis." World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS) 4 (2015): 1621-1628. |
| 16 | Hypolipidemic Activity | Veeramani, Chinnaveeramani, Ganesan Pushpavalli, and Kodukkur Viswanathan Pugalendi. "In vivo antioxidant and hypolipidemic effect of Cardiospermum halicacabum leaf extract in streptozotocin-induced diabetic rats." Journal of Basic and Clinical Physiology and Pharmacology 21.2 (2010): 107-126. Raza, Syed Atif, et al. "Review of beneficial and remedial aspects of Cardiospermum halicacabum L." African Journal of Pharmacy and Pharmacology 7.48 (2013): 3026-3033. Veeramani, Chinnadurai, et al. "Influence of Cardiospermum halicacabum leaf extract on membrane-bound ATPases in streptozotocin-induced diabetic rats." African Journal of Traditional, Complementary and Alternative Medicines 12.3 (2015): 68-74. Irudayaraj, Santiagu Stephen, et al. "In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats." Food and chemical toxicology 60 (2013): 135-140. Okokon, Jude E., et al. "Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats." Phytomedicine Plus 2.1 (2022): 100182. Rahman, Shahid, et al. "Phytochemical screening and antidiabetic, antihyperlipidemic, and antioxidant effects of Leptopus cordifolius Decne. in diabetic mice." Frontiers in Pharmacology 12 (2021): 643242. Devanathan, Krishnamoorthy. "Cardiospermum halicacabum L. Sapindaceae." Ethnobotany of the Mountain Regions of Southeast Asia (2020): 1-9. Ramachandran, Subramaniam, et al. "Antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark in type 2 diabetic rats." Asian Pacific Journal of Tropical Disease 2 (2012): S596-S602. |
| 17 | Hepatoprotective Activity | Jeyadevi, R., et al. "Phenolic profiling by UPLC–MS/MS and hepatoprotective activity of Cardiospermum halicacabum against CCl4 induced liver injury in Wistar rats." Journal of Functional Foods 5.1 (2013): 289-298. Prabakaran, S., et al. "Hepatoprotective effect of Pisonia alba and Cardiospermum halicacabum in atrazine toxicity on LPO and some antioxidant activities in the liver tissue of fresh water fish Labeo rohita." Int. J. Pharm. Biol. Arch 5.2 (2014): 1231-1237. Chinnadurai, S. Aruljothiselvi G., and R. Periyanayagi. "HEPATOPROTECTIVE EFFECT OF CARDIOSPERMUM HALICACABUM IN CYPERMETHRIN TOXICITY ON LPO AND SOME ANTIOXIDANT ACTIVITIES IN THE LIVER TISSUE OF FRESH WATER FISH CYPRINUS CARPIO (HAMILTON)." Int. J. Modn. Res. Revs 4.6 (2016): 1168-1171. Aishwarya, V., et al. "In vitro antioxidant and anticancer activity of Cardiospermum halicacabum L. against EAC cell line." Int J Pharm Pharm Sci 6.8 (2014): 263-8. Velmurugan, V., et al. "Evaluation of Diuretic Activity on Leaves Extract of Cardiospermum halicacabum Linn." Research Journal of Pharmacy and Technology 12.4 (2019): 1607-1609. Rajeswari, R., and M. Sriidevi. "Isolation of active compounds from hydro alcoholic extract of cardiospermum Halicacabum Linn." International Journal of Pharmaceutical Sciences and Research 5.11 (2014): 4832. Lee, Dong‑Sung, et al. "Protective effects of Cambodian medicinal plants on tert‑butyl hydroperoxide‑induced hepatotoxicity via Nrf2‑mediated heme oxygenase‑1." Molecular medicine reports 15.1 (2017): 451-459. |
Market Overview
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